Drivers of resting-state fMRI heterogeneity in traumatic brain injury across injury characteristics and imaging methods: a systematic review and semiquantitative analysis DOI Creative Commons

Alexander W. Kashou,

Daniel M. Frees,

Kaylee Kang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 27, 2024

Traumatic brain injury (TBI) is common and costly. Although neuroimaging modalities such as resting-state functional MRI (rsfMRI) promise to differentiate injured from healthy brains prognosticate long-term outcomes, the field suffers heterogeneous findings. To assess whether this heterogeneity stems variability in TBI populations studied or imaging methods used, determine a consensus exists literature, we performed first systematic review of studies comparing rsfMRI connectivity (FC) patients with matched controls for seven canonical networks across severity, age, chronicity, population type, various methods. Searching PubMed, Web Science, Google Scholar, ScienceDirect, 1,105 manuscripts were identified, 50 fulfilling our criteria. Across these manuscripts, 179 comparisons reported between total 1,397 1,179 controls. Collapsing characteristics, methods, networks, there roughly equal significant null findings increased decreased differences reported. Whereas most factors did not explain mixed findings, stratifying severity separately, showed trend at higher severities greater chronicities TBI. Among methodological factors, more likely find when scans longer than 360 s, custom image processing pipelines kept their eyes open versus closed during scans. We offer guidelines address variability, focusing on aspects study design acquisition move toward reproducible results potential clinical translation.

Language: Английский

Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO DOI Creative Commons
Sue J. Hong,

Bradley J. De Souza,

Kristen K. Penberthy

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: 22(1), P. e00521 - e00521

Published: Jan. 1, 2025

Language: Английский

Citations

1
Advances in spectroscopic detection of traumatic brain injury biomarkers: Potential for diagnostic applications DOI
Yowhan Son,

Moon‐Young Jeong,

Jong Min Lim

et al.

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 30

Published: April 4, 2025

Language: Английский

Citations

1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders DOI Creative Commons
Duraisamy Kempuraj,

Kirk D. Dourvetakis,

Jessica R. Cohen

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 25, 2024

Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.

Language: Английский

Citations

6
A Systematic Review and Meta-Analysis of Major Blood Protein Biomarkers that Predict Unfavorable Outcomes in Severe Traumatic Brain Injury DOI
Faraz Behzadi, Diego D. Luy,

Peter Schaible

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 242, P. 108312 - 108312

Published: April 30, 2024

Language: Английский

Citations

5
Fluid biomarkers of chronic traumatic brain injury DOI

Susanna Friberg,

Caroline Lindblad, Frederick A. Zeiler

et al.

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

4
Serum metabolic fingerprinting on Ag@AuNWs for traumatic brain injury diagnosis DOI

Jing-Ling Qiang,

Yanling Liu, Jian Zhu

et al.

Nanotechnology, Journal Year: 2025, Volume and Issue: 36(13), P. 135101 - 135101

Published: Jan. 14, 2025

Accurate and rapid diagnosis of traumatic brain injury (TBI) is very important for high quality medical services. Nonetheless, the current diagnostic platform still has challenges in accurate analysis clinical samples. Here, we prepared a highly stable, repeatable sensitive gold-plated silver core-shell nanowire (Ag@AuNWs) surface-enhanced Raman spectroscopy (SERS) metabolic fingerprint TBI. The structure significantly enhanced SERS intensity enables direct detection 10μl serum within seconds. principal component analysis-linear discriminant (PCA-LDA) partial least squares-DA (PLS-DA) are used to evaluate classification effect this technology on TBI, respectively. accuracy rate PCA-LDA PLS-DA 73.3% 86.7% diagnosing Consequently, model optimal selection distinguishing between TBI sham groups. This research will facilitate application-oriented creation novel materials with tailored structural designs formulation innovative precision protocols imminent future.

Language: Английский

Citations

0
The Value of Clinical Decision Support in Healthcare: A Focus on Screening and Early Detection DOI Creative Commons
Hendrik Schäfer,

Nesrine Lajmi,

P. Valente

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 648 - 648

Published: March 6, 2025

In a rapidly changing technology landscape, “Clinical Decision Support” (CDS) has become an important tool to improve patient management. CDS systems offer medical professionals new insights diagnostic accuracy, therapy planning, and personalized treatment. addition, provide cost-effective options augment conventional screening for secondary prevention. This review aims (i) describe the purpose mechanisms of systems, (ii) discuss different entities algorithms, (iii) highlight quality features, (iv) challenges limitations in clinical practice. Furthermore, we (v) contemporary algorithms oncology, acute care, cardiology, nephrology. particular, consolidate research on across diseases that imply significant disease economic burden, such as lung cancer, colorectal hepatocellular coronary artery disease, traumatic brain injury, sepsis, chronic kidney disease.

Language: Английский

Citations

0
Insights into computer-aided EEG signal processing for traumatic brain injury assessment: A review DOI

Farzaneh Manzari,

Peyvand Ghaderyan

Measurement, Journal Year: 2025, Volume and Issue: unknown, P. 117279 - 117279

Published: March 1, 2025

Language: Английский

Citations

0
A novel and mass-sensitive quartz tuning fork platform for glial fibrillary acidic protein determination DOI
Burcu Özcan, İnci Uludağ, Mehmet Altay Ünal

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113408 - 113408

Published: March 1, 2025

Language: Английский

Citations

0
Modeling biomarker kinetics of Aβ levels in serum following blast DOI Creative Commons
Carly Norris, Harsha T. Garimella, Walter Carr

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Elucidating the unique neuropathological response to blast exposure remains a barrier towards development of diagnostic approaches for those with blast-induced traumatic brain injury (bTBI). Quantification biomarker concentrations in blood post-injury is typically used inform severity. However, progression and associated changes are sensitive parameters such as overpressure (BOP) magnitude frequency exposure. Through this work, blast-dose kinetics (BxK) platform was developed validated Aβ42 promising predictor post-blast. Blast-dose responses accounting BOP were integrated into mathematical model whole-body Aβ peptide kinetics. Validation performed through comparison acute monomer levels serum 15 service members exposed repeated low-level while undergoing three-day weapons training. Amyloid precursor protein (APP) synthesis assumed be proportional additive effects within window recovery applied account cumulative predicted 6.5 ± 5.2% on average, demonstrating feasibility sensitivity blast. Outcomes discuss how modulation patient-specific factors (age, weight, genetic factors, years exposure, sleep) pathophysiological (BBB permeability, amyloidogenic pathology, neuroinflammation) can reveal potential sources variability experimental data incorporated BxK future iterations. Advancements complexity sex-specific weapon system, stress levels, risk symptom onset, pharmacological treatment strategies anticipated improve calibration. Utilization identify drivers mechanisms predict chronic outcomes has transform bTBI diagnostic, prognostic, therapeutic strategies.

Language: Английский

Citations

0