Molecules,
Journal Year:
2022,
Volume and Issue:
27(6), P. 1816 - 1816
Published: March 10, 2022
Acetylcholine,
a
neurotransmitter
secreted
by
cholinergic
neurons,
is
involved
in
signal
transduction
related
to
memory
and
learning
ability.
Alzheimer’s
disease
(AD),
progressive
commonly
diagnosed
neurodegenerative
disease,
characterized
cognitive
decline
behavioral
disorders.
The
pathogenesis
of
AD
complex
remains
unclear,
being
affected
various
factors.
hypothesis
the
earliest
theory
about
AD.
Cholinergic
atrophy
are
accelerated
age-related
diseases
such
as
In
addition,
abnormal
central
changes
can
also
induce
phosphorylation
ttau
protein,
nerve
cell
inflammation,
apoptosis,
other
pathological
phenomena,
but
exact
mechanism
action
still
unclear.
Due
unclear
pathogenesis,
effective
methods
prevent
treat
unavailable,
research
explore
novel
therapeutic
drugs
active
world.
This
review
summaries
role
signaling
correlation
between
pathway
with
risk
factors
provides
latest
efficient
treatment
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: July 4, 2023
Lycium
barbarum
glycopeptide
(LbGp)
is
the
main
bioactive
compound
extracted
from
traditional
Chinese
medicine.
L.
berries
and
has
been
proven
to
have
numerous
health
benefits,
including
antioxidative,
anti-inflammatory,
anticancer,
cytoprotective
activities.
However,
antiaging
effect
of
LbGp
remains
unknown.The
lifespan
body
movement
C.
elegans
were
used
evaluate
on
span.
The
thrashing
assay
was
determine
role
in
Parkinson's
disease.
To
investigate
mechanisms
LbGp-induced
effects,
we
analyzed
changes
lifespan,
movement,
expression
longevity-related
genes
a
series
worm
mutants
after
treatment.We
found
that
treatment
prolonged
span
elegans.
Mechanistically,
could
activate
transcription
factors
DAF-16/FOXO,
SKN-1/Nrf2,
HSF-1,
as
well
nuclear
receptor
DAF-12,
thereby
upregulating
achieve
extension.
In
addition,
extension
induced
by
partially
depends
mitochondrial
function.
Intriguingly,
also
ameliorated
neurodegenerative
diseases
such
disease
DAF-16-,
SKN-1-,
HSF-1-dependent
manner.Our
work
suggests
might
be
viable
candidate
for
prevention
aging
age-related
diseases.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 9, 2024
Parkinson's
disease
(PD)
and
Dementia
with
Lewy
Bodies
(DLB)
are
neurodegenerative
disorders
characterized
by
the
accumulation
of
α-synuclein
aggregates.
forms
droplets
via
liquid-liquid
phase
separation
(LLPS),
followed
liquid-solid
(LSPS)
to
form
amyloids,
how
this
process
is
physiologically-regulated
remains
unclear.
β-synuclein
colocalizes
in
presynaptic
terminals.
Here,
we
report
that
partitions
into
condensates
promotes
LLPS,
slows
down
LSPS
α-synuclein,
while
disease-associated
mutations
lose
these
capacities.
Exogenous
improves
movement
defects
prolongs
lifespan
an
α-synuclein-expressing
NL5901
Caenorhabditis
elegans
strain,
mutants
aggravate
symptoms.
Decapeptides
targeted
at
α-/β-synuclein
interaction
sites
rationally
designed,
which
suppress
rescue
defects,
prolong
C.
NL5901.
Together,
unveil
a
Yin-Yang
balance
between
α-
underlying
normal
states
PD
DLB
therapeutical
potentials.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Oct. 2, 2023
Abstract
PIWI-interacting
RNAs
(piRNAs)
are
small
noncoding
that
regulate
gene
expression,
yet
their
molecular
functions
in
neurobiology
unclear.
While
investigating
neurodegeneration
mechanisms
using
human
α-syn(A53T)
Tg
and
Aβ
;α-syn(A53T)
pan-neuronal
overexpressing
strains,
we
unexpectedly
observed
dysregulation
of
piRNAs.
RNAi
screening
revealed
knock
down
piRNA
biogenesis
genes
improved
thrashing
behavior;
further,
a
tofu-1
deletion
ameliorated
phenotypic
deficits
transgenic
strains.
expression
was
extensively
downregulated
H3K9me3
marks
were
decreased
after
Dysregulated
piRNAs
targeted
protein
degradation
suggesting
decrease
leads
to
an
increase
ability
C.
elegans
.
Finally,
interrogated
brain
samples
from
PD
patients.
be
widely
overexpressed
at
late
motor
stage.
In
this
work,
our
results
provide
evidence
mediators
pathogenesis
Lewy
body
diseases
suggest
mechanism
for
these
related
disorders.
Current Neuropharmacology,
Journal Year:
2023,
Volume and Issue:
22(7), P. 1156 - 1168
Published: Aug. 18, 2023
Autism
spectrum
disorder
(ASD)
includes
a
heterogeneous
group
of
complex
neurodevelopmental
disorders
characterized
by
atypical
behaviors
with
two
core
pathological
manifestations:
deficits
in
social
interaction/communication
and
repetitive
behaviors,
which
are
associated
disturbed
redox
homeostasis.
Modulation
cellular
resilience
mechanisms
induced
low
levels
stressors
represents
novel
approach
for
the
development
therapeutic
strategies,
this
context,
neuroprotective
effects
wide
range
polyphenol
compounds
have
been
demonstrated
several
vitro
vivo
studies
thoroughly
reviewed.
Mushrooms
used
traditional
medicine
many
years
long
list
properties,
including
antitumor,
immunomodulatory,
antioxidant,
antiviral,
antibacterial,
hepatoprotective
effects.
Our
recent
strikingly
indicated
presence
polyphenols
nutritional
mushrooms
their
protective
different
models
neurodegenerative
humans
rats.
Although
exerted
through
multiple
mechanisms,
increasing
attention
is
focusing
on
capacity
to
induce
endogenous
defense
systems
modulating
signaling
processes
such
as
nuclear
factor
erythroid
2
related
(Nrf2)
factor-kappa
B
(NF-κB)
pathways.
Here
we
discuss
role
hormesis
its
modulation
hormetic
nutrients
ASD.
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: March 26, 2025
Caenorhabditis
elegans
has
been
widely
used
as
a
model
organism
in
neurodevelopment
for
several
decades
due
to
its
simplicity,
rapid
growth,
short
life
cycle,
transparency,
and
rather
simple
genetics.
It
useful
modeling
neurodegenerative
diseases
by
the
heterologous
expression
of
major
proteins
that
form
neurodegenerative-linked
aggregates
such
amyloid-
β
peptide,
tau
protein,
α
-synuclein,
among
others.
Furthermore,
chemical
treatments
well
existence
interference
RNA
libraries,
transgenic
worm
lines,
possibility
generating
new
strains
create
magnificent
range
possible
tools
study
signaling
pathways
could
confer
protection
against
protein
or,
on
contrary,
are
playing
detrimental
role.
In
this
review,
we
summarize
different
C.
models
with
focus
Alzheimer’s
Parkinson’s
how
genetic
be
dissect
involved
their
pathogenesis
mentioning
examples.
Finally,
discuss
use
pharmacological
agents
help
these
disease-associated
powerful
combinations
experimental
designs
tools.
This
review
highlights
advantages
valuable
intermediary
between
vitro
mammalian
vivo
development
potential
therapies.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(7), P. 2877 - 2893
Published: March 15, 2023
Parkinson's
disease
(P.D.)
is
the
second
most
progressive
neurodegenerative
disorder
in
elderly.
Degeneration
of
dopaminergic
(DA)
neurons
and
α-synuclein
(α-Syn)
accumulated
toxicity
major
contributor
to
this
disease.
At
present,
has
no
effective
treatment.
Many
recent
studies
focus
on
identifying
novel
therapeutics
that
provide
benefits
stop
progression
P.D.
patients.
Screening
drugs
animal
models
time-
cost-consuming.
Rose
Essential
Oil
(REO)
extracted
from
Rosa
Rugosa
species
(R.
Setate
×
R.
Rugosa).
REO
contains
Citronellol,
Geraniol,
Octadiene
possess
anti-Aβ,
anti-oxidative,
anti-depression-like
properties,
but
reports
have
defined
effect
yet.
The
present
study
examines
neuroprotective
potential
transgenic
Caenorhabditis
elegans
models.
We
observed
reduced
α-Syn
aggregations
diminished
DA
neuron
degenerations
induced
by
6-OHDA,
food-sensing
behavioural
disabilities,
prolonged
lifespan
nematode.
Moreover,
augmented
chymotrypsin-like
proteasome
SOD-3
activities.
Further,
we
anti-oxidative
role
reducing
internal
cells
ROS.
Together,
these
findings
supported
as
an
anti-PD
drug
may
exert
its
effects
lowering
oxidative
stress
via
pathway.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 19
Published: Aug. 8, 2022
Chronic
cerebral
hypoperfusion
(CCH)
is
a
cardinal
risk
factor
for
Parkinson’s
disease
dementia
(PDD),
but
this
potential
causality
lacks
mechanistic
evidence.
We
selected
bilateral
common
carotid
artery
occlusion
(BCCAO)
to
simulate
chronic
in
the
rat
model
of
PD
induced
by
typical
neurotoxin
6-hydroxy
dopamine
(6-OHDA).
Four
weeks
after
unilateral
injection
6-OHDA
into
medial
forebrain
bundle,
rats
underwent
BCCAO.
Male
Sprague-Dawley
were
divided
five
groups
ten,
including
sham,
PD+BCCAO
2
weeks,
1
week,
PD,
and
BCCAO
weeks.
Then,
open
field
test
(OFT)
Morris
water
maze
(MWM)
used
assess
PDD-like
symptoms
rats.
Also,
pathological
manifestations
mechanisms
impairing
cognitive
functions
have
been
explored
via
hematoxylin-eosin
staining,
Nissl
immunohistochemistry,
immunofluorescence,
RNA
sequencing
analysis,
lipidomics,
quantitative
real-time
polymerase
chain
reaction.
In
study,
we
found
that
CCH
could
aggravate
(i.e.,
learning
memory
spatial
cognition)
pathology
(higher
expression
α-Syn
Aβ
prefrontal
cortex
striatum).
Moreover,
relationship
between
differentially
expressed
mRNAs
lipid
metabolism
was
revealed
analysis.
Lipidomics
showed
affect
intensity
5
lipids,
sphingomyelin
(SM
9:0;2O/26:2;
SM
8:1;2O/25:0;
8:0;2O/28:4),
cardiolipin,
lysophosphatidylcholine,
cholesteryl
ester,
triacylglycerol.
Interestingly,
KEGG
pathway
analysis
both
lipidomics
suggested
leaded
impairment
affecting
sphingolipid
metabolism.
Finally,
disrupts
mRNA
SMPD1
SMS2,
leading
accumulation
cortex.
summary,
CCH,
an
independent
exacerbating
reason
within
pathopoiesis
aggravates
dementia-like
6-OHDA-lesioned
through
interfering
with
