Microbial Pathogenesis,
Journal Year:
2024,
Volume and Issue:
197, P. 107091 - 107091
Published: Oct. 30, 2024
The
discoveries
of
the
oncomicrobiome
(intratumoral
microbiome)
and
oncomicrobiota
microbiota)
represent
significant
advances
in
tumor
research
have
rapidly
become
key
interest
to
field.
Within
tumors,
microorganisms
such
as
bacteria,
fungi,
viruses,
archaea
form
are
primarily
found
within
cells,
immunocytes,
intercellular
matrix.
exhibits
marked
heterogeneity
is
associated
with
initiation,
progression,
metastasis,
treatment
response.
Interactions
between
immune
system
can
modulate
host
antitumor
immunity,
influencing
efficacy
immunotherapies.
Oncomicrobiome
also
faces
numerous
challenges,
including
overcoming
methodological
issues
low
target
abundance,
susceptibility
contamination,
biases
sample
handling
analysis
methods
across
different
studies.
Furthermore,
studies
may
be
confounded
by
baseline
differences
microbiomes
among
populations
driven
both
environmental
genetic
factors.
Most
date
revealed
associations
but
very
few
established
mechanistic
links
two.
This
review
introduces
relevant
concepts,
detection
methods,
sources,
characteristics
oncomicrobiome.
We
then
describe
composition
common
tumors
its
role
shaping
microenvironment.
discuss
current
problems
challenges
overcome
this
progressing
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 10, 2024
Abstract
Human
microorganisms,
including
bacteria,
fungi,
and
viruses,
play
key
roles
in
several
physiological
pathological
processes.
Some
studies
discovered
that
tumour
tissues
once
considered
sterile
actually
host
a
variety
of
which
have
been
confirmed
to
be
closely
related
oncogenesis.
The
concept
intratumoural
microbiota
was
subsequently
proposed.
Microbiota
could
colonise
through
mucosal
destruction,
adjacent
tissue
migration,
hematogenic
invasion
affect
the
biological
behaviour
tumours
as
an
important
part
microenvironment.
Mechanistic
demonstrated
potentially
promote
initiation
progression
by
inducing
genomic
instability
mutations,
affecting
epigenetic
modifications,
promoting
inflammation
response,
avoiding
immune
regulating
metabolism,
activating
metastasis.
Since
more
comprehensive
profound
insights
about
intratumoral
are
continuously
emerging,
new
methods
for
early
diagnosis
prognostic
assessment
cancer
patients
under
examination.
In
addition,
interventions
based
on
show
great
potential
open
chapter
antitumour
therapy,
especially
immunotherapy,
although
there
some
inevitable
challenges.
Here,
we
aim
provide
extensive
review
concept,
development
history,
sources,
heterogeneity,
carcinogenic
mechanisms
explore
role
microorganisms
prognosis,
discuss
current
treatment
regimens
target
research
prospects
limitations
this
field.
Journal of Pharmaceutical Analysis,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1429 - 1451
Published: Aug. 24, 2023
With
the
continuous
discovery
and
research
of
predictive
cancer-related
biomarkers,
liquid
biopsy
shows
great
potential
in
cancer
diagnosis.
Surface-enhanced
Raman
scattering
(SERS)
microfluidic
technology
have
received
much
attention
among
various
biomarker
detection
methods.
The
former
has
ultrahigh
sensitivity
can
provide
a
unique
fingerprint.
In
contrast,
latter
characteristics
miniaturization
integration,
which
realize
accurate
control
samples
high-throughput
through
design.
Both
for
point-of-care
testing
(POCT),
their
combination
(lab-on-a-chip
SERS
(LoC-SERS))
good
compatibility.
this
paper,
basic
situation
circulating
proteins,
tumor
cells,
exosomes,
DNA
(ctDNA),
microRNA
(miRNA)
diagnosis
cancers
is
reviewed,
these
biomarkers
by
LoC-SERS
platform
recent
years
described
detail.
At
same
time,
challenges
future
development
are
discussed
at
end
review.
Summarizing
current
expected
to
reference
scholars
engaged
related
work
interested
field.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 3973 - 3988
Published: July 1, 2023
Abstract:
Pancreatic
cancer
is
a
highly
malignant
and
incurable
disease,
characterized
by
its
aggressive
nature
high
fatality
rate.
The
most
common
type
pancreatic
ductal
adenocarcinoma
(PDAC),
which
has
poor
prognosis
mortality
Current
treatments
for
mainly
encompass
surgery,
chemotherapy,
radiotherapy,
targeted
therapy,
combination
regimens.
However,
despite
efforts
to
improve
prognosis,
the
5-year
survival
rate
remains
very
low.
Therefore,
it's
urgent
explore
novel
therapeutic
approaches.
With
rapid
development
of
strategies
in
recent
years,
new
ideas
have
been
provided
treating
cancer.
This
review
expositions
advancements
nano
drug
delivery
system,
molecular
drugs,
photo-thermal
treatment
combined
with
nanotechnology
It
comprehensively
analyzes
prospects
cancer,
aiming
at
deeper
understanding
existing
drugs
approaches,
promoting
attempting
enhance
effect
patients
this
disease.
Keywords:
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Jan. 12, 2024
Abstract
Extracellular
vesicles
(EVs)
have
gained
increasing
recognition
as
significant
regulators
of
intercellular
communication
in
various
physiological
and
pathological
processes.
These
play
a
pivotal
role
cancer
progression
by
facilitating
the
transfer
diverse
cargoes,
including
lipids,
proteins,
nucleic
acids.
Regulated
cell
death
(RCD),
orderly
autonomous
cells,
is
controlled
variety
biomacromolecules
and,
turn,
influences
biological
processes
progression.
Recent
studies
demonstrated
that
EV
cargoes
regulate
oncogenes
tumor
suppressors
to
mediate
different
nonapoptotic
forms
RCD,
notably
ferroptosis,
pyroptosis,
necroptosis.
Nevertheless,
comprehensive
exploration
EV-mediated
RCD
context
has
not
been
performed.
This
review
summarizes
progress
regarding
functions
underlying
mechanisms
EVs
mediating
delivery
Additionally,
delves
into
potential
clinical
applications
its
significance
areas
diagnosis
therapy.
International Journal of Nanomedicine,
Journal Year:
2022,
Volume and Issue:
Volume 17, P. 6113 - 6129
Published: Dec. 1, 2022
Abstract:
Extracellular
vesicles
(EVs)
can
contain
DNA,
RNA,
proteins
and
metabolic
molecules
from
primary
origins;
they
are
coated
with
a
phospholipid
bilayer
membrane
released
by
cells
into
the
extracellular
matrix.
EVs
be
obtained
various
body
liquids,
including
blood,
saliva,
cerebrospinal
fluid,
urine.
As
has
been
proved,
EVs-mediated
transfer
of
biologically
active
is
crucial
for
physiological
pathological
processes.
Extensive
investigations
have
already
begun
to
explore
diagnosis
prognosis
potentials
EVs.
Furthermore,
research
continued
recognize
critical
role
nucleic
acids
in
However,
our
understanding
comprehensive
effects
metabolites
these
nanoparticles
currently
limited
its
infancy.
Therefore,
we
attempted
summarize
recent
metabolomics
relation
potential
clinical
applications
discuss
problems
challenges
that
occurred,
provide
more
guidance
future
development
this
field.
Keywords:
vesicles,
metabolomics,
metabolites,
application
Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(2), P. 587 - 597
Published: Jan. 31, 2024
JOURNAL/nrgr/04.03/01300535-202502000-00034/figure1/v/2024-05-28T214302Z/r/image-tiff
Several
studies
have
found
that
transplantation
of
neural
progenitor
cells
(NPCs)
promotes
the
survival
injured
neurons.
However,
a
poor
integration
rate
and
high
risk
tumorigenicity
after
cell
limits
their
clinical
application.
Small
extracellular
vesicles
(sEVs)
contain
bioactive
molecules
for
neuronal
protection
regeneration.
Previous
shown
stem/progenitor
cell-derived
sEVs
can
promote
recovery
neurological
function
in
neurodegenerative
eye
diseases
other
diseases.
In
this
study,
we
intravitreally
transplanted
derived
from
human
induced
pluripotent
stem
(hiPSCs)
hiPSCs-differentiated
NPCs
(hiPSC-NPC)
mouse
model
optic
nerve
crush.
Our
results
show
these
injected
were
ingested
by
retinal
cells,
especially
those
localized
ganglion
layer.
Treatment
with
hiPSC-NPC-derived
mitigated
crush-induced
degeneration,
regulated
microenvironment
inhibiting
excessive
activation
microglia.
Component
analysis
further
revealed
hiPSC-NPC
transported
neuroprotective
anti-inflammatory
miRNA
cargos
to
target
which
had
protective
effects
on
RGCs
injury.
These
findings
suggest
are
promising
cell-free
therapeutic
strategy
neuropathy.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 16, 2023
Extracellular
vesicles
(EVs),
including
exosomes,
play
a
crucial
role
in
intercellular
communication
and
have
emerged
as
important
mediators
the
development
progression
of
gastric
cancer.
This
review
discusses
current
understanding
EVs,
particularly
exosomal
lncRNA
microRNA,
cancer
their
potential
diagnostic
therapeutic
targets.
Exosomes
are
small
membrane-bound
particles
secreted
by
both
cells
stromal
within
tumor
microenvironment.
They
contain
various
ncRNA
biomolecules,
which
can
be
transferred
to
recipient
promote
growth
metastasis.
In
this
review,
we
highlighted
importance
microRNA
Exosomal
lncRNAs
been
shown
regulate
gene
expression
interacting
with
transcription
factors
or
chromatin-modifying
enzymes,
binding
target
mRNAs.
We
also
discuss
use
microRNAs
biomarkers
for
isolated
from
bodily
fluids,
blood,
urine,
saliva.
specific
molecules
that
reflect
molecular
characteristics
tumor,
making
them
promising
candidates
non-invasive
tests.
Finally,
targeting
strategy
were
reviewed
wee.
Inhibition
exosomes
has
suppress
metastasis
preclinical
models.
conclusion,
article
provides
an
overview
suggest
further
research
into
these
could
lead
new
tools
strategies
deadly
disease.
