Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis DOI Creative Commons
Ryo Miyake, Manabu D. Yamanaka,

Wataru Taniguchi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, spinal cord, and brain. Neuropathic leads to changes in synaptic plasticity anterior cingulate cortex (ACC). However, whether such occur OA mice their association with exercise therapy remains unclear. Therefore, this study investigated these aspects using electrophysiological behavioral approaches. We found no induction pre- or post-long-term potentiation (LTP) ACC mice. Application ZD7288 zeta inhibitory peptide (ZIP) reduced amplitude evoked excitatory postsynaptic currents, indicating pre-existing ACC. Microinjection ZIP improved pain-escape anxiety-like behaviors. Voluntary running induced post-LTP behaviors Exercise for may alter ACC, contributing improvements.

Language: Английский

The anatomy of pain and suffering in the brain and its clinical implications DOI Creative Commons
Dirk De Ridder, Divya Adhia, Sven Vanneste

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 130, P. 125 - 146

Published: Aug. 16, 2021

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Chronic pain, a prevalence of 20-30 % the major cause human suffering worldwide, because effective, specific safe therapies have yet to be developed. It unevenly distributed among sexes, women experiencing more pain suffering. can anatomically phenomenologically dissected into three separable but interacting pathways, lateral 'painfulness' pathway, medial 'suffering' pathway descending inhibitory pathway. One may pain(fullness) without pain(fullness). sensation leads via cognitive, autonomic processing, expressed as anger, fear, frustration, anxiety depression. The overlaps salience stress networks, explaining that behavioural relevance meaning determines painfulness. Genetic epigenetic influences trigger chronic neuroinflammatory changes which are involved in transitioning from acute pain. Based on concept Bayesian brain, (and suffering) regarded consequence imbalance between two ascending pathways under control reward system. therapeutic clinical implications this simple model obvious. After categorizing working mechanisms each available treatments (pain killers, psychopharmacology, psychotherapy, neuromodulation, psychosurgery, spinal cord stimulation) 1 3 rational combination proposed activating inhibition so rebalance pathways.

Language: Английский

Citations

162
Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis DOI Creative Commons

Chu-Yang Zeng,

Zhenrong Zhang, Zhiming Tang

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 16, 2021

Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone degeneration, as well synovitis, are the main pathological changes associated with knee osteoarthritis. Mechanical overload, inflammation, metabolic factors, hormonal changes, aging play vital role in aggravating progression of The treatments for include pharmacotherapy, physiotherapy, surgery. However, pharmacotherapy has many side effects, surgery only suitable patients end-stage Exercise training, complementary adjunctive can prevent cartilage inhibit loss metaphyseal trabeculae. Increasing evidence indicates that exercise training improve pain, stiffness, joint dysfunction, muscle weakness There several trainings options treatment osteoarthritis, including aerobic exercise, strength neuromuscular balance proprioception aquatic traditional exercise. For (KOA) experimental animals, those reduce delay change tendon, structure. In this review, we summarize symptoms mechanisms therapeutic effects different methods on We hope review will allow situations to receive appropriate therapy provide reference further research clinical application

Language: Английский

Citations

144
Osteoarthritis year in review 2020: rehabilitation and outcomes DOI Creative Commons
Jackie L. Whittaker, Linda Truong, Kartar Singh Dhiman

et al.

Osteoarthritis and Cartilage, Journal Year: 2020, Volume and Issue: 29(2), P. 190 - 207

Published: Nov. 24, 2020

Language: Английский

Citations

73
Exercise Therapy for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis DOI Creative Commons

Ling Mo,

Banghua Jiang,

Tao Mei

et al.

Orthopaedic Journal of Sports Medicine, Journal Year: 2023, Volume and Issue: 11(5)

Published: May 1, 2023

Background: Exercise is an effective nonpharmaceutical therapy for knee osteoarthritis (KOA). Purpose: To identify the most type of exercise KOA with regard to pain, stiffness, joint function, and quality life. Study Design: Systematic review; Level evidence, 3. Methods: The PubMed, Web Science, Embase, Cochrane Library databases were searched, from inception April 4, 2022. Included randomized controlled trials that assessed efficacy on among 5 different groups (aquatic [AE], stationary cycling [CY], resistance training [RT], traditional [TC], yoga [YG]) compared control group. Outcomes Western Ontario McMaster University Osteoarthritis Index (WOMAC), 6-minute walk test (6-MWT), visual analog scale (VAS) Knee injury Outcome Score (KOOS); weighted mean differences (WMDs) 95% confidence intervals calculated. Network meta-analyses comparing outcomes between all controls performed, group rankings calculated using surface under cumulative ranking curve (SUCRA). Results: A total 39 studies (N = 2646 participants) included. Most failed blind participants researchers, resulting in a high risk performance bias. Significantly worse WOMAC-Pain scores seen interventions except AE (WMD [95% CI]: CY, –4.45 [–5.69 –3.20]; RT, –4.28 [–5.48 –3.07]; TC, –4.20 [–5.37 –3.04]; YG, –0.57 [–1.04 –1.04]), YG regarding WOMAC-Stiffness (WMD, –1.40 CI, –2.45 –0.34]) WOMAC-Function –0.49 –0.95 –0.02]). According SUCRA, CY was improving (80.8%) 6-MWT (76.1%); (90.6%), (77.4%), KOOS–Activities Daily Living (72.0%), KOOS–Quality Life (79.1%); VAS pain (77.2%) KOOS-Pain (64.0%); RT KOOS-Symptoms (84.5%). Conclusion: All types able ameliorate KOA. (for relief) limited life) approaches, followed by TC.

Language: Английский

Citations

31
Knee osteoarthritis pain and stretching exercises: a systematic review and meta-analysis DOI
Lijiang Luan, Doa El‐Ansary, Roger Adams

et al.

Physiotherapy, Journal Year: 2021, Volume and Issue: 114, P. 16 - 29

Published: Oct. 12, 2021

Language: Английский

Citations

42
Stationary cycling exercise for knee osteoarthritis: A systematic review and meta-analysis DOI
Lijiang Luan, Jaquelin A. Bousie, Adrian Pranata

et al.

Clinical Rehabilitation, Journal Year: 2020, Volume and Issue: 35(4), P. 522 - 533

Published: Nov. 10, 2020

Objective: To evaluate effects of stationary cycling exercise on pain, function and stiffness in individuals with knee osteoarthritis. Data sources: Systematic search conducted seven databases (PubMed, Embase, Cochrane Library, Web Science, EBSCO, PEDro, CNKI) from inception to September 2020. Review methods: Included studies were randomized-controlled trials involving End-trial weighted mean difference (WMD) 95% confidence interval (CI) analyzed, random-effects models used. Methodological quality risk bias assessed by using the Physiotherapy Evidence Database scale Collaboration tool, respectively. Results: Eleven 724 participants found, which final meta-analysis was performed eight. Compared a control (no exercise), resulted reduced pain (WMD 12.86, CI 6.90–18.81) improved sport performance 8.06, 0.92–15.20); although most results statistically significant, improvements 11.47, 4.69–18.25), 8.28, 2.44–14.11), symptoms 4.15, −1.87 10.18), daily living 6.43, 3.19 9.66) life 0.99, −4.27 6.25) for osteoarthritis not greater than minimal clinically important values each these outcome measures. Conclusions: Stationary relieves improves osteoarthritis, but may be as effective improving stiffness, activity, life.

Language: Английский

Citations

46
The Safety of Baduanjin Exercise: A Systematic Review DOI Open Access
Jianqi Fang, Liying Zhang, Fangzhen Wu

et al.

Evidence-based Complementary and Alternative Medicine, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 11

Published: Jan. 21, 2021

Objectives. Baduanjin exercise is a form of Qigong therapy that has become increasingly popular worldwide. The aims the current systematic review were to summarize reported adverse events potentially associated with based on currently available literature and evaluate quality methods used monitor in trials assessed. Methods. English databases PubMed, Cochrane library, EMbase searched from inception October 2020 using keywords “Baduanjin” or “eight session brocade.” Only studies included included. Results. Forty-seven total 3877 participants this review. Twenty-two protocols for monitoring events, two occurrence during training. palpitation, giddiness, knee pain, backache, fatigue, nervousness, dizziness, shoulder chest tightness, shortness breath, muscle ache. Conclusions. caused by exercise. Adverse related patients chronic fatigue syndrome may include ache, breath. Further conducted accordance Consolidated Standards Reporting Trials statement guideline incorporating are recommended. Additional clinical which as main intervention needed, further meta-analysis be required assess its safety reach more informed conclusions regard future.

Language: Английский

Citations

38
A comparative analysis of automatic classification and grading methods for knee osteoarthritis focussing on X-ray images DOI
Deepak Saini,

Trilok Chand,

Devendra Kumar Chouhan

et al.

Journal of Applied Biomedicine, Journal Year: 2021, Volume and Issue: 41(2), P. 419 - 444

Published: April 1, 2021

Language: Английский

Citations

35
Effects of Mini-Basketball Training Program on Social Communication Impairment and Executive Control Network in Preschool Children with Autism Spectrum Disorder DOI Open Access
Sixin Yang, Zhimei Liu, Xuan Xiong

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(10), P. 5132 - 5132

Published: May 12, 2021

This study evaluated the effect of a 12-week mini-basketball training program (MBTP) on social communication (SC) and executive control network (ECN) in preschool children with autism spectrum disorders (ASD). We finally assigned 30 ASD to an experiment group (n = 15, 12 males, 3 females) or 13 2 females). The participated MBTP (40-min sessions per day, 5 days week), while only received institutional routine behavioral rehabilitation intervention. SC was measured using Social Responsiveness Scale, Second Edition (SRS-2), whereas functional connectivity (FC) ECN assessed resting-state magnetic resonance imaging (rs-fMRI) at pre-and post-test. Our results showed that exhibited significant improvement intervention group, especially SRS-2 total score, cognition, communication. found significantly enhanced between right cerebellum left inferior frontal gyrus experimental middle temporal were decreased group. Furthermore, there no correlations change scores FC ECN. Altogether, this provides valuable insights improves ASD. further inferred neural mechanisms might be associated changing caused by MBTP.

Language: Английский

Citations

34
The Effectiveness of Traditional Chinese Yijinjing Qigong Exercise for the Patients With Knee Osteoarthritis on the Pain, Dysfunction, and Mood Disorder: A Pilot Randomized Controlled Trial DOI Creative Commons
Shuaipan Zhang, Guangxin Guo, Xing Li

et al.

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 8

Published: Jan. 11, 2022

Background: Although traditional Chinese Yijinjing Qigong Exercise (YJJQE) is popularly used in China, to alleviate symptoms of people with knee osteoarthritis (KOA), no randomized controlled trials (RCTs) are available evaluate the effects YJJQE patients KOA. The purpose this trial assess clinical efficacy for Methods: A total 50 participants clinically diagnosed KOA randomly (1:1) assigned group (n = 25) and stretching training exercise (STE) 25), a 40-min session twice week 12 weeks. All outcome measures collected at baseline 12-week ending intervention, which includes primary outcomes Western Ontario McMaster Universities Osteoarthritis Index Scale (WOMAC), secondary visual analog scale (VAS), mental component summary (MCS), physical (PCS), Beck depression inventory (BDI), perceived stress (PSS), Berg balance (BBS), Gait functional mobility data. Results: did not have any significant changes compared control on WOMAC score after intervention (P > 0.05), though demonstrated better performance MCS, BDI, PSS 0.002, P 0.001, 0.026, respectively) than group. No serious adverse events occurred either group, only mild muscle soreness was reported during both treatments. Conclusion: Because difference between groups shown, regards measurement it can hardly explain that had an advantageous effect experiencing pain dysfunction osteoarthritis. However, appeared be associated improvements psychological well-being including reduced stress, anxiety, depression, mood disturbance manage Further larger sample sizes follow-up studies will required. Clinical Trial Registration: https://www.chictr.org.cn/edit.aspx?pid=60357&htm=4, ChiCTR2000037256.

Language: Английский

Citations

25