Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive

Neural Regeneration Research, Journal Year: 2020, Volume and Issue: 16(3), P. 543 - 543

Published: Sept. 23, 2020

Previous studies have shown that Lycium barbarum polysaccharide, the main active component of barbarum, exhibits anti-inflammatory and antioxidant effects in treating neurological diseases. However, therapeutic action polysaccharide on depression has not been studied. In this investigation, we established mouse models using aversive stimuli including exposure to fox urine, air puff foot shock physical restraint. Concurrently, administered 5 mg/kg per day polysaccharide-glycoprotein each intragastrically for 28 days. Our results showed long-term significantly enhanced depressive-like behavior evaluated by sucrose preference test forced swimming increased anxiety-like behaviors open field test. addition, stimuli-induced depressed mice exhibited aberrant neuronal activity lateral habenula. Importantly, concurrent treatment reduced these changes. These findings suggest is a potential preventative intervention may act preventing microglial activation The study was approved Jinan University Institutional Animal Care Use Committee (approval No. 20170301003) March 1, 2017.

Language: Английский

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Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk

Frontiers in Molecular Neuroscience, Journal Year: 2021, Volume and Issue: 14

Published: Nov. 4, 2021

The relationship between the central nervous system (CNS) and microglia is lifelong. Microglia originate in embryonic yolk sac during development populate CNS before blood-brain barrier forms. In CNS, they constitute a self-renewing population. Although represent up to 10% of all brain cells, we are only beginning understand how much homeostasis relies on their physiological functions. Often compared double-edged sword, hold potential exert neuroprotective roles that can also exacerbate neurodegeneration once compromised. promote synaptic growth addition eliminating synapses less active. Synaptic loss, which considered one best pathological correlates cognitive decline, distinctive feature major depressive disorder (MDD) aging. Long-term psychological stress accelerates cellular aging predisposes various diseases, including MDD, decline. Among underlying mechanisms, stress-induced neuroinflammation alters microglial interactions with surrounding parenchymal cells exacerbates oxidative burden damage, hence inducing changes neurons typical Focusing synapses, this review discusses disrupted communication these notably involving fractalkine signaling triggering receptor expressed myeloid (TREM). Overall, chronic emerges as key player by altering sensome, via deficiency. To study aging, novel positron emission tomography radiotracers for TREM purinergic family receptors show interest human study.

Language: Английский

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Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 315, P. 116658 - 116658

Published: May 31, 2023

Language: Английский

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The Potential Effects of the Ketogenic Diet in the Prevention and Co-Treatment of Stress, Anxiety, Depression, Schizophrenia, and Bipolar Disorder: From the Basic Research to the Clinical Practice

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1546 - 1546

Published: May 21, 2024

Background: The ketogenic diet (KD) has been highly developed in the past for treatment of epileptic pathological states children and adults. Recently, current re-emergence its popularity mainly focuses on therapy cardiometabolic diseases. KD can also have anti-inflammatory neuroprotective activities which may be applied to prevention and/or co-treatment a diverse range psychiatric disorders. Purpose: This is comprehensive literature review that intends critically collect scrutinize pre-existing research basis clinical data potential advantageous impacts stress, anxiety, depression, schizophrenia bipolar disorder. Methods: was performed thoroughly represent existing this topic, as well find gaps international scientific community. In aspect, we carefully investigated ultimate web databases, e.g., PubMed, Scopus, Web Science, derive currently available animal human surveys by using efficient representative keywords. Results: Just recent years, an increasing amount focused investigating possible schizophrenia, Pre-existing basic with studies consistently demonstrated promising results KD, showing propensity ameliorate symptoms However, translation these findings settings presents more complex issue. majority seem moderate, usually not controlled, assessed short-term effects KD. addition, some appear characterized enormous dropout rates significant absence compliance measurement, elevated heterogeneity their methodological design. Conclusions: Although evidence seems promising, it recommended accomplish larger, long-term, randomized, double-blind, controlled trials prospective design, order conclusive whether could act preventative factor or even agent against Basic examine molecular mechanisms above

Language: Английский

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Therapeutic Potential of the Ketogenic Diet: A Metabolic Switch with Implications for Neurological Disorders, the Gut-Brain Axis, and Cardiovascular Diseases

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 132, P. 109693 - 109693

Published: June 15, 2024

Language: Английский

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