Neuropsychiatric Disease and Treatment,
Journal Year:
2024,
Volume and Issue:
Volume 20, P. 631 - 647
Published: March 1, 2024
Purpose:
Chronic
inflammation
is
one
of
the
key
mechanisms
depression.Wenyang-Tianjin-Jie
Decoction
(WTJD)
an
effective
antidepressant
found
in
course
diagnosis
and
treatment,
but
mechanism
therapeutic
effect
not
clear.The
study
aimed
to
evaluate
efficacy
WTJD
kidney
yang
deficiency
(KYD)
type
depression
rats
reveal
its
mechanisms.Materials
Methods:
We
selected
forty
6-week-old
male
Sprague-Dawley
for
study.We
established
a
KYD
[Phellodendron
amurense
Rupr
(Huangbai)
solution
oral
gavage
4°C
environments;
8
weeks]
(chronic
unpredictable
mild
stimulus;
6
weeks)
rat
model
first.After
successful
modeling,
we
used
or
fluoxetine
on
3
weeks.Then
evaluated
behavior.Finally,
observed
expression
inflammatory
factors
proteins
peripheral
blood
hippocampus,
further
investigated
immune
balance
Th17/Treg
Th1/Th2
cells
activity
their
main
regulatory
pathways
JAK2/STAT3
TLR4/TRAF6/NF-κB.
Results:The
imbalance
were
related
depressive
symptoms.Through
this
study,
that
can
inhibit
TLR4/TRAF6/NF-κB
pathways,
cell
homeostasis,
regulate
levels
hippocampus
blood,
reverse
depression.
Conclusion:This
confirmed
had
reliable
with
KYD,
was
homeostasis
hippocampal
T
improve
symptoms
rats.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 22, 2024
Depression,
a
global
health
problem
with
growing
prevalence,
brings
serious
impacts
on
the
daily
life
of
patients.
However,
antidepressants
currently
used
in
clinical
are
not
perfectly
effective,
which
greatly
reduces
compliance
Berberine
is
natural
quaternary
alkaloid
has
been
shown
to
have
variety
pharmacological
effects,
such
as
hypoglycemic,
lipid-regulation,
anti-cancer,
antibacterial,
anti-oxidation,
anti-inflammatory,
and
antidepressant.
This
review
summarizes
evidence
applications
berberine
treating
depression
elucidates
mechanisms
regulating
neurotransmitter
levels,
promoting
regeneration
hippocampal
neurons,
improving
hypothalamic-pituitary-adrenal
axis
dysfunction,
anti-oxidative
stress,
suppressing
inflammatory
status
order
provide
reference
for
further
research
application
berberine.
Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: April 15, 2025
Abstract
Background
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
predominantly
affecting
the
elderly
population.
It
characterized
by
cognitive
deficits
associated
with
accumulation
of
amyloid-beta
plaques
and
neurofibrillary
tangles.
Huang-Lian-Jie-Du
(HLJD)
decoction,
recognized
as
representative
formulation
heat-clearing
detoxification
effects,
has
been
demonstrated
to
be
effective
in
treating
AD.
However,
underlying
mechanisms
require
further
investigation.
Methods
5xFAD
mice
were
administrated
low
high
doses
HLJD.
The
Morris
water
maze
test
was
conducted
assess
effects
Aβ42
total
tau
protein
levels
evaluated.
Additionally,
network
pharmacology
analysis
performed
identify
therapeutic
targets
HLJD’s
active
components
their
relevance
ELISA,
qPCR,
Western
Blot,
immunofluorescence
assays
employed
confirm
identified
pathways.
Finally,
primary
microglia
isolated
from
used
validate
candidate
Results
HLJD
improved
reduced
amyloid
plaque
deposition
levels.
Network
indicated
that
influences
neuroinflammatory
response,
particularly
through
Dap12
signaling
pathway.
This
confirmed
neuroinflammation
markers,
including
TNF-α,
IL-1β,
IL-6,
indicators
microglial
activation
polarization.
expression
Trem2
hippocampus
(HIP)
mice,
well
microglia,
downregulated
following
treatment.
Conclusion
Our
study
indicates
alleviates
AD
suppressing
Trem2/Dap12
pathway
HIP
thereby
inhibiting
neuroinflammation.
Graphical
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 26, 2024
Introduction
Ulcerative
colitis,
a
subtype
of
chronic
inflammatory
bowel
disease
(IBD),
is
characterized
by
relapsing
colonic
inflammation
and
ulcers.
The
traditional
Chinese
herbal
formulation
Huang
Lian
Jie
Du
(HLJD)
decoction
used
clinically
to
treat
diarrhea
colitis.
However,
the
mechanisms
associated
with
effects
treatment
remain
unclear.
This
study
aims
elucidate
molecular
mechanistic
HLJD
on
Methods
Chronic
colitis
in
mice
was
induced
adding
1%
dextran
sulfate
sodium
(DSS)
their
drinking
water
continuously
for
8
weeks,
at
doses
2
4
g/kg
administered
orally
daily
from
second
week
until
experimental
endpoint.
Stool
consistency
scores,
blood
stool
body
weights
were
recorded
weekly.
Disease
activity
index
(DAI)
determined
before
necropsy,
where
colon
tissues
collected
biochemical
analyses.
In
addition,
fecal
microbiome
treated
using
16S
rRNA
amplicon
sequencing.
Results
relieved
DSS-induced
suppressing
through
compromised
macrophage
colony-stimulating
factor
1
receptor
(Csf1r)/Src
pathway.
Furthermore,
formula
could
modify
gut
microbiota
profile
decreasing
abundance
Bacteroides
,
Odoribacter
Clostridium_sensu_stricto_1
Parasutterella
.
close
correlations
between
DAI,
length,
spleen
weight,
identified.
Discussion
Our
findings
revealed
that
attenuated
reducing
via
Csf1r/Src-mediated
infiltration,
as
well
modulating
profile.
