Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis

Journal of Infection, Journal Year: 2023, Volume and Issue: 88(2), P. 77 - 88

Published: Dec. 13, 2023

This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection.

Language: Английский

---

Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

Angiogenesis, Journal Year: 2023, Volume and Issue: 26(4), P. 547 - 563

Published: July 28, 2023

Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in high impact on the daily life of patients. Understanding pathophysiology PCS public health priority, it still poses diagnostic treatment challenge for physicians.In this prospective observational cohort study, we analyzed retinal microcirculation using Retinal Vessel Analysis (RVA) patients compared to an age- gender-matched healthy (n = 41, matched out n 204).PCS exhibit persistent endothelial dysfunction (ED), indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% 2.59%; p 0.02), narrower central artery equivalent (CRAE; 178.1 [167.5-190.2] 189.1 [179.4-197.2], 0.01) arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] 0.88 [0.8-0.9], 0.007). When combining AVR vFID, predicted scores reached good ability discriminate groups (area under curve: 0.75). Higher severity correlated (R - 0.37 0.017). The association microvascular changes were amplified exhibiting higher levels inflammatory parameters.Our results demonstrate that prolonged hallmark PCS, impairments seem explain As potential therapies emerge, RVA parameters may become relevant clinical biomarkers diagnosis therapy management.This study was previously registered at ClinicalTrials ("All Eyes PCS-Analysis Microvasculature Patients Syndrome". NCT05635552. https://clinicaltrials.gov/ct2/show/NCT05635552 ). Persistent post-COVID-19 syndrome. Acute SARS-CoV-2 infection indirectly or directly causes endotheliitis N 41 recruited vessel analysis performed assess function. Images SVA DVA are illustrative data analysis. For each patient cohort, diameter three measurement cycles calculated plotted diameter-time curve. exhibited reduced veins (vFID) measured dynamic (DVA) arteriolar (CRAE) (AVR) tendency towards (CRVE) when naïve participants. Created BioRender.com.

Language: Английский

---

Long COVID or Post-COVID-19 Condition: Past, Present and Future Research Directions

Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2959 - 2959

Published: Dec. 11, 2023

The presence of symptoms after an acute SARS-CoV-2 infection (long-COVID) has become a worldwide healthcare emergency but remains underestimated and undertreated due to lack recognition the condition knowledge underlying mechanisms. In fact, prevalence post-COVID ranges from 50% during first months up 20% two-years after. This perspective review aimed map existing literature on identify gaps in guide global effort toward improved understanding long-COVID suggest future research directions. There is plethora symptomatology that can be COVID-19; however, today, there no clear classification definition this condition, termed or post-COVID-19 condition. heterogeneity led groups/clusters patients, which could exhibit different risk factors Viral persistence, long-lasting inflammation, immune dysregulation, autoimmune reactions, reactivation latent infections, endothelial dysfunction alteration gut microbiota have been proposed as potential mechanisms explaining complexity long-COVID. such equation, viral biology (e.g., re-infections, variants), host genetics, epigenetics) external vaccination) should also considered. These various will discussed current directions suggested.

Language: Английский

---

Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101798 - 101798

Published: Oct. 30, 2024

Language: Английский

---

From Acute Infection to Prolonged Health Consequences: Understanding Health Disparities and Economic Implications in Long COVID Worldwide

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(3), P. 325 - 325

Published: March 11, 2024

The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. COVID is characterized by recurring inflammation across multiple organ systems. Diagnosis can be challenging, influenced factors like demographics, comorbidities, immune responses. impacts various systems have neuropsychological effects. Health disparities, particularly related to race, contribute higher burden infection ongoing minority populations. Managing entails addressing spectrum that encompass physical, cognitive, psychological aspects. recovery period for with vary significantly, the severity disease, hospitalization, age. Currently, there are no universally effective treatments, although certain interventions show promise, necessitating further research. Self-management rehabilitation programs provide relief, but more research needed establish their effectiveness. Preventive measures such vaccination use antiviral medications metformin. It imperative conduct develop evidence-based guidelines gain better understanding long-term implications COVID-19. could substantial economic impact on labor market, productivity, healthcare expenditures, overall growth. To address challenges complications face, focus strategies promoting telework flexible work arrangements accommodate diverse symptoms, chronic fatigue other In conclusion, this review emphasizes multifaceted complexity need its potential health impacts.

Language: Английский

---

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Foods, Journal Year: 2022, Volume and Issue: 11(18), P. 2884 - 2884

Published: Sept. 17, 2022

The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment

Language: Английский

---

Measurement of burnout during the prolonged pandemic in the Chinese zero-COVID context: COVID-19 burnout views scale

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 10, 2022

Burnout is an important public health issue at times of the COVID-19 pandemic. Current measures which focus on work-based burnout have limitations in length and/or relevance. When stepping into post-pandemic as a new Norm Era, scale for general population urgently needed to fill gap. This study aimed develop Views Scale (COVID-19 BVS) measure views Chinese context and examine its psychometric properties. A multiphase approach including literature review, expert consultation, pilot testing was adopted developing scale. The administered sample 1,078 Hong Kong with average age 34.45 years (SD = 12.47). Exploratory Confirmatory Factor Analyses suggested 5-item unidimensional model BVS. CFA results indicated that BVS had good fit, χ2 (10.054)/5 2.01, SRMR 0.010, CFI 0.998, RMSEA 0.031. Five items were maintained EFA high internal consistency terms Cronbach's α 0.845 McDonald's ω coefficient 0.87, corrected item-to-total correlations 0.512 0.789 are way above acceptable range. KMO values 0.841 Bartlett's Test Sphericity (p < 0.01) verified normal distribution adequacy sampling. analyses suggest promising tool assessing impacts epidemic populations.

Language: Английский

---

The treatment of depression — searching for new ideas

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 7, 2022

Depression is a severe mental health problem that affects people regardless of social status or education, associated with changes in mood and behavior, can result suicide attempt. Therapy depressive disorders based mainly on drugs discovered the 1960s early 1970s. Selective serotonin reuptake inhibitors (SSRIs) serotonin-norepinephrine (SNRIs) are frontline pharmacological strategies for medical treatment depression. In addition, approved by FDA 2019, esketamine [as nasal spray; N-methyl-D-aspartate (NMDA) receptors antagonist additional effects α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, L-type voltage-dependent calcium channel (L-VDCC), opioid monoaminergic receptors] an essential compound drug-resistant However, depression burdened side effects, many cases, it ineffective. An equally important issue choice antidepressant therapy comorbid somatic diseases, example, due to possible interactions patient's other drugs. Therefore, there great need new antidepressants different mechanisms action refine search substances. The purpose this review was discuss research directions trends dominate laboratories worldwide. We have reviewed literature present points target substances activity. we propose perspective therapies.

Language: Английский

---

Long-COVID syndrome: physical–mental interplay in the spotlight

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(2), P. 559 - 564

Published: March 9, 2023

Patients suffering from Long-COVID syndrome experience a variety of different symptoms on physical, but also psychological and social level. Previous psychiatric conditions such as depression anxiety have been identified separate risk factors for developing syndrome. This suggests complex interplay physical mental rather than simple cause-effect relationship specific biological pathogenic process. The biopsychosocial model provides foundation understanding these interactions integrating them into broader perspective the patient disease instead individual symptoms, pointing towards need treatment options well level besides targets. leads to our conclusion, that should be underlying philosophy understanding, diagnosing treating patients syndrome, moving away strictly biomedical suspected by many patients, treaters media while reducing stigma still associated with suggestion physical-mental interplay.

Language: Английский

---

Vortioxetine improves physical and cognitive symptoms in patients with post-COVID-19 major depressive episodes

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 70, P. 21 - 28

Published: Feb. 8, 2023

Language: Английский

---