Immune system and its neurophysiology DOI
Aditi Banerjee

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 295 - 319

Published: Oct. 1, 2024

Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology DOI Creative Commons
David R. Goldsmith, Mandakh Bekhbat, Neeti D. Mehta

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(5), P. 405 - 418

Published: Nov. 9, 2022

Language: Английский

Citations

117
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms DOI Creative Commons
Jiao Wang, Jiayi Lin,

Yanfang Deng

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

Citations

5
Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment DOI Creative Commons
Jenessa N. Johnston, Bashkim Kadriu, Josh Allen

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 226, P. 109422 - 109422

Published: Jan. 13, 2023

Language: Английский

Citations

35
Childhood Maltreatment and Amygdala Response to Interpersonal Threat in a Transdiagnostic Adult Sample: The Role of Trait Dissociation DOI
K. Seitz, Maurizio Sicorello, Marius Schmitz

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(6), P. 626 - 634

Published: Jan. 26, 2024

Language: Английский

Citations

7
A theory of the neural mechanisms underlying negative cognitive bias in major depression DOI Creative Commons

Yuyue Jiang

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

The widely acknowledged cognitive theory of depression, developed by Aaron Beck, focused on biased information processing that emphasizes the negative aspects affective and conceptual information. Current attempts to discover neurological mechanism underlying such bias have successfully identified various brain regions associated with severally functions as emotion, attention, rumination, inhibition control. However, neurobiological mechanisms how individuals in depression develop this selective toward is still under question. This paper introduces a framework centered around frontal-limbic circuit, specifically analyzing synthesizing activity functional connectivity within amygdala, hippocampus, medial prefrontal cortex. Firstly, possible explanation positive feedback loop contributes persistent hyperactivity amygdala at an automatic level established. Building upon this, two hypotheses are presented: hypothesis 1 revolves bidirectional amygdalohippocampal projection facilitating amplification emotions memories while concurrently contributing impediment retrieval opposing hippocampus attractor network. Hypothesis 2 highlights involvement ventromedial cortex establishment through generalization emotional conjunction hippocampus. primary objective study improve complement existing pathological models pushing frontiers current understanding neuroscience disorders, eventually successful recovery from debilitating disorders.

Language: Английский

Citations

7
Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review DOI

Ziyi Han,

Leyu Wang,

Huanqing Zhu

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115191 - 115191

Published: Oct. 18, 2024

Language: Английский

Citations

5
Alterations in magnetic susceptibility correlate with higher cerebral blood flow in the right amygdala of patients with major depressive disorder DOI Creative Commons
Qianyun Chen,

Zhifeng Zhou,

Hongyan Huang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Depicting Coupling Between Cortical Morphology and Functional Networks in Major Depressive Disorder DOI Creative Commons
Peng Wang, Liwei Lu,

Jinghua Wang

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

An enduring mystery in neuroscience is the intricate interplay between brain anatomical structure and functional dynamics, particularly context of mental disorders such as major depressive disorder (MDD). A pivotal scientific question arises: How does cortical morphology-function coupling (MFC) manifest MDD, what insights can this provide into clinical manifestations disorder? To tackle question, we conducted a comprehensive analysis using high-resolution T1-weighted structural magnetic resonance imaging (MRI) resting-state MRI (rs-fMRI) data from cohort 830 MDD patients 853 healthy control (HC). By constructing morphological networks based on gray matter (GM) morphology regional rs-fMRI time series correlations, respectively, aimed to quantify MFC by assessing spatial correspondence these networks. Results revealed that exhibited hierarchical pattern similar HC, with variations specific Specifically, lower was observed visual network (VIS) sensorimotor (SMN), while higher noted default mode (DMN) frontoparietal (FPN). Notably, demonstrated significantly increased within VIS, SMN, dorsal attention (DAN) compared HC. Furthermore, altered VIS correlated positively symptom severity. These findings contribute our understanding potential significance alterations MDD.

Language: Английский

Citations

0
Self-perceptive feature fusion network with multi-channel graph convolution for brain disorder diagnosis DOI
Xueliang Jiang,

Xinshun Ding,

Zhengwang Xia

et al.

Expert Systems with Applications, Journal Year: 2025, Volume and Issue: unknown, P. 127984 - 127984

Published: May 1, 2025

Language: Английский

Citations

0
Impaired perception of trustworthy faces at low spatial frequency (LSF) and untrustworthy faces at high spatial frequency (HSF) in individuals with higher beck depression inventory scores DOI
Gewnhi Park, Nam Hee Kim,

Lydia Grenko

et al.

Visual Cognition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: May 13, 2025

Language: Английский

Citations

0