Neurobiology and systems biology of stress resilience

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263

Published: March 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Language: Английский

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From Clinic to Mechanisms: Multi-Omics Provide New Insights into Cerebrospinal Fluid Metabolites and the Spectrum of Psychiatric Disorders

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

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Add-On Bifidobacterium Bifidum Supplement in Children with Attention-Deficit/Hyperactivity Disorder: A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2260 - 2260

Published: July 13, 2024

We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving stable dose methylphenidate (MPH) treatment enrolled and randomly assigned two groups: one add-on Bf-688 (daily bacterial count 5 × 109 CFUs) (n = 51) other placebo 51). All participants underwent assessments using Conners’ Continuous Performance Test (CPT) Auditory Attention (CATA). Additionally, fecal samples collected at beginning (week 0) endpoint 12). Remarkably, group supplementation, but not group, exhibited significant improvements in omission errors CPT as well Hit reaction time both CATA. Gut microbiome analysis revealed increase Firmicutes Bacteroidetes ratio (F/B ratio) only group. Furthermore, we identified negative correlations between N-Glycan biosynthesis Our results demonstrate that probiotic supplement can enhance neuropsychological performance children ADHD, possibly by altering composition gut microbiota, ultimately leading reduced biosynthesis.

Language: Английский

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Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 2, 2024

Background Androgenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate potential causal relationship Methods A MR investigation was utilized into intricate interplay Information regarding 211 microbial taxa sourced from MiBioGen consortium. The summary statistics genome-wide (GWAS) for AGA were obtained FinnGen biobank, which included 195 cases 201,019 controls. Various analytical approaches, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger, Mode, Simple Mode employed evaluate impact on Sensitivity analyses subsequently conducted affirm robustness findings. Results unveiled genus Olsenella , Ruminococcaceae UCG-004 UCG-010 identified as risk factors associated with In contrast, family Acidaminococcaceae Anaerofilum along Ruminiclostridium 9, demonstrated protective effect. sensitivity provided additional assurance that findings current study less susceptible influence confounding variables biases. Conclusion has established link specific AGA, offering evidence identification more precisely targeted probiotics. This discovery aid in prevention, control, reversal progression.

Language: Английский

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Exploring the causal relationship between gut microbiota and multiple myeloma risk based on Mendelian randomization and biological annotation

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 12, 2024

Introduction The microbial genome-wide association studies (mbGWAS) have highlighted significant host-microbiome interactions based on microbiome heritability. However, establishing causal relationships between particular microbiota and multiple myeloma (MM) remains challenging due to limited sample sizes. Methods Gut data from a GWAS with 18,340 participants MM summary statistics 456,348 individuals. inverse variance-weighted (IVW) method was used as the main bidirectional Mendelian randomization (MR) analysis. To assess robustness of our results, we further performed supplementary analyses, including MR pleiotropy residual sum outlier (MR-PRESSO) test, MR-Egger, Weighted median, Simple mode, mode. Moreover, backward analysis conducted investigate potential for reverse causation. Finally, gene gene-set-based analyses were then explore common biological factors connecting gut MM. Results We discovered that 10 taxa causally related risk. Among them, family Acidaminococcaceae , Bacteroidales S24-7, Porphyromonadaceae genus Eubacterium ruminantium group Parabacteroides Turicibacter positively correlated Conversely, class Verrucomicrobia Verrucomicrobiaceae Akkermansia order Verrucomicrobiales negatively heterogeneity test revealed no Heterogeneity. MR-Egger MR-PRESSO tests showed horizontal pleiotropy. Importantly, leave-one-out confirmed results. In analysis, statistically associations taxa. Lastly, identified novel shared genes (AUTS2, CDK2, ERBB3, IKZF4, PMEL, SUOX, RAB5B) are associated immunoregulation prognosis in through annotation. Discussion Overall, this study provides evidence supporting relationship risk, while also revealing relevant clinical prognosis.

Language: Английский

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Alterations in fecal bacteriome virome interplay and microbiota-derived dysfunction in patients with schizophrenia

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 29, 2025

Rising studies have consistently reported gut bacteriome alterations in schizophrenia (SCZ). However, little is known about the role of virome on shaping SCZ. Here in, we sequenced fecal virome, bacteriome, and host peripheral metabolome 49 SCZ patients health controls (HCs). We compared bacterial community composition specific abundant bacteria HCs. Specific viruses metabolites co-occurring with differential were identified using Multiple Co-inertia Analysis (MCIA). Additionally, construct a latent serial mediation model (SMM) to investigate effect through metabolic profile. exhibited decreased β-diversity HCs, seven differentially bacteria, including Coprobacillaceae, Enterococcaceae etc. Gut Suoliviridae Rountreeviridae, co-occur these SCZ-related bacteria. found that viral-bacterial transkingdom correlations observed HCs dramatically lost The altered profile may impact microbiota-derived enriched bile acids pathway, eicosanoids others, contributing immune dysfunction inflammation. SMM suggested potential causal chains between SCZ, indicating significantly mediated by metabolites. In conclusion, findings provide comprehensive perspective microbiota pathogenesis They reveal harbor an abnormal virome-bacteriome ecology, shedding light development microbial therapeutics.

Language: Английский

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Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample mendelian randomization analysis

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 6, 2025

Language: Английский

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Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 1, 2025

The complex interactions between host genetics and the gut microbiome are well documented. However, specific impacts of gene expression patterns microbial composition on each other remain to be further explored. Here, we investigated this interplay in a sizable population 705 hens, employing integrative analyses examine relationships among genome, mucosal expression, microbiota. Specific taxa, such as cecal family Christensenellaceae, which showed heritability 0.365, were strongly correlated with genomic variants. We proposed novel concept regulatability ( $${r}_{b}^{2}$$ ), was derived from h2, quantify cumulative effects given phenotypes. duodenal transcriptome emerged potent influencer much higher values (0.17 ± 0.01, mean SE) than h2 (0.02 0.00). A comparative analysis chickens humans revealed similar average microbiability genes (0.18 vs. 0.20) significant differences microbes 0.04). Besides, cis $${h}_{\text{cis}}^{2}$$ ) trans $${h}_{\text{trans}}^{2}$$ estimated assess genetic variations inside outside window its expression. Higher greater prevalence trans-regulated cis-regulated underscored role loci shaping levels. Furthermore, our exploration regulatory microbiota 18 traits enhanced understanding mechanisms, CHST14 Lactobacillus salivarius jointly facilitated deposition abdominal fat by modulating concentration bile salt hydrolase, triglycerides, total cholesterol, free fatty acids absorption metabolism. Our findings highlighted phenotypic variance attributed emphasize superior intestinal expressions over elucidating host‒microbe for traits. This could assist devising strategies modulate host–microbe interactions, ultimately improving economic chickens. hepatic transcriptomes, integrated elucidate mechanisms underlying phenotypes Heritability estimation GWASs transcriptome, collectively calculated By integrating genome data, cis- trans-heritability estimated, methods eQTL mapping SMR used conducted explore extent shapes microbiota, exploring degree interaction combining all analytical mentioned above, more advanced comprehensive manner that regulate can achieved.

Language: Английский

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Causal link between gut microbiota and obsessive-compulsive disorder: A two-sample Mendelian randomization analysis

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Causal Link between Gut Microbiota and Myopia—A Two-Sample Mendelian Randomization Analysis

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1063 - 1074

Published: Jan. 1, 2025

Language: Английский

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