Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Journal of Clinical Nursing, Journal Year: 2023, Volume and Issue: 32(17-18), P. 5445 - 5460
Published: Jan. 27, 2023
Abstract Background Medication administration errors (MAEs) cause preventable patient harm and cost billions of dollars from already‐strained healthcare budgets. An emerging factor contributing to these is nurse fatigue. Given medication the most frequent clinical task nurses undertake; it vital understand how fatigue impacts MAEs. Objective Examine evidence on effect MAEs near misses by registered working in hospital settings. Method Arksey O'Malley's scoping review framework was used guide this PAGER for data extraction analysis. The PRISMA checklist completed. Four electronic databases were searched: CINAHL, PubMed, Scopus PsycINFO. Eligibility criteria included primary peer papers published English Language with no date/time limiters applied. search completed August 2021 focussed articles that included: (a) settings, (b) MAEs, (c) measures sleep, hours work, or Results Thirty‐eight studies review. 82% identified be a (NMs). Fatigue associated reduced cognitive performance lack attention vigilance. It poor nursing decreased safety. Components shift such as disruption circadian rhythm overtime factors. However, there marked heterogeneity strategies measuring within studies. Relevance practice multidimensional concept has capacity impact nurses' when engaged administration. Nurses are susceptible due work characteristics nightwork, requirement perform cognitively demanding tasks. mixed results found indicate larger scale needed particular emphasis work. Policy around safe need re‐evaluated management systems put place ensure delivery quality care.
Language: Английский
Citations
46
BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 28, 2025
Language: Английский
Citations
3
Journal of Nuclear Medicine, Journal Year: 2022, Volume and Issue: 63(7), P. 971 - 980
Published: Feb. 17, 2022
Molecular imaging techniques like positron emission tomography (PET) and single-photon computed (SPECT) have been used to shed light on how the Corona Virus Disease 2019 (COVID-19) affects human brain. We provide a systematic review that summarizes current literature according five predominant topics: 1. Few case reports suggest reversible cortical subcortical metabolic alterations in rare cases with concomitant, para- or post-infectious encephalitis. 2. Imaging findings single patients first manifestations of parkinsonism context COVID-19 resemble those neurodegenerative (loss nigrostriatal integrity), but scarceness data lack follow-up preclude further etiological conclusions (e.g., unmasking/hastening neurodegeneration vs. (para-) infectious parkinsonism). 3. Several few studies addressed focal symptoms lesions, most notably hyposmia. Results are variable, although some found regional hypometabolism regions related olfaction orbitofrontal mesiotemporal). 4. A series inpatients COVID-19-related encephalopathy (acute subacute stage) consistently frontoparietal-dominant neocortical dysfunction (on clinically) proved be grossly majority until 6 months. 5. Studies "Post-COVID-19 syndrome" provided controversial results. In high level self-reported complaints fatigue, memory impairment, hyposmia, dyspnea) authors extensive areas limbic hypometabolism, while others no PET only minor cognitive impairments (if any) neuropsychological assessment. Furthermore, we critical appraisal regard frequent methodological issues pathophysiological concepts. Finally, devised possible applications SPECT clinical work-up diagnostic questions COVID-19.
Language: Английский
Citations
65
Stress and Health, Journal Year: 2023, Volume and Issue: 39(4), P. 813 - 827
Published: Jan. 16, 2023
Abstract Fatigue is a common presenting problem in healthcare settings, often attributed to chronic psychosocial stress. Understanding of fatigue and development evidence‐based treatments hampered by lack consensus regarding diagnostic definitions outcomes be measured clinical trials. This study aimed map outcome domains importance the Swedish diagnosis stress‐induced exhaustion disorder (ED; ICD‐10, code F43.8 A). An online survey was distributed nationwide Sweden individuals who reported have been diagnosed with ED professionals working patients. To identify domains, participants replied anonymously four open‐ended questions about symptoms expectations for ED‐treatment. Qualitative content analysis conducted randomized subsample respondents, using mathematical model determine data saturation. Six hundred seventy (573 ED, 97 professionals) completed survey. answers supplied 105 identified 87 encompassing physical, cognitive, emotional as well functional disability. Self‐rating scales indicated that many participants, beyond reporting fatigue, also moderate severe depression, anxiety, insomnia, poor self‐rated health, sickness behavior. presents ED. Results shed light on panorama issues deal can used step further understand condition reach measure trials stress fatigue. Preregistration : Open Science Framework (osf.io) DOI https://doi.org/10.17605/OSF.IO/4VUAG
Language: Английский
Citations
24
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 261 - 261
Published: Feb. 15, 2025
Long-lasting brain fatigue is a consequence of stroke or traumatic injury associated with emotional, psychological, and physical overload, distress in hypertension, atherosclerosis, viral infection, aging-related chronic low-grade inflammatory disorders. The pathogenesis linked to disrupted neurotransmission, the glutamate-glutamine cycle imbalance, glucose metabolism, ATP energy supply, which are multiple molecular targets signaling pathways neuroendocrine-immune blood circulation systems. Regeneration damaged tissue long-lasting multistage process, including spontaneously regulating hypothalamus-pituitary (HPA) axis-controlled anabolic-catabolic homeostasis recover harmonized sympathoadrenal system (SAS)-mediated function, deregulated gene expression rehabilitation. driving mechanism spontaneous recovery regeneration cross-talk mediators neuronal, microglia, immunocompetent, endothelial cells collectively involved neurogenesis angiogenesis, plant adaptogens can target. Adaptogens small molecules origin that increase adaptability organisms stress by interaction HPA axis SAS (neuroendocrine-immune cardiovascular complex), targeting adaptive GPCR pathways. Two major groups comprise (i) phenolic phenethyl phenylpropanoid derivatives (ii) tetracyclic pentacyclic glycosides, whose chemical structure be distinguished as related correspondingly monoamine neurotransmitters (epinephrine, norepinephrine, dopamine) steroid hormones (cortisol, testosterone, estradiol). In this narrative review, we discuss multitarget integrated pharmacological activity botanical ischemic stroke, fatigue; time-dependent dual response physiological regulatory systems support overload; (iii) dose-dependent reversal (hormetic) effect adaptogens. This review shows adaptogenic concept cannot reduced rectified various effects on selected specific modes action without estimating their interactions within networks complex that, turn, regulates other (cardiovascular, gastrointestinal, reproductive systems) due numerous intra- extracellular communications feedback regulations. These result polyvalent pleiotropic adaptogens, essential for characterizing distinct types botanicals. They trigger defense leads extension limits resilience inducing mental For first time, justifies potential particularly hybrid preparation (BHP) Arctic Root Ashwagandha, providing rationale use individuals experiencing fatigue. provided insight into future research network pharmacology preventing rehabilitating following trauma, infections.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142802 - 142802
Published: April 1, 2025
Language: Английский
Citations
1
BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: Oct. 17, 2022
Abstract Background Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression fatigue. These highly prevalent especially active disease, potentially due to inflammation-mediated changes the microbiota-gut-brain axis. The aim of this study was investigate associations between structural functional microbiota characteristics severity fatigue depressive patients with IBD. Methods We included clinical data 62 prospectively enrolled IBD an disease state. Patients supplied stool samples completed questionnaires regarding symptoms. Based on taxonomic metagenomic profiles faecal gut microbiota, we used Bayesian statistics associative networks triangle motifs bacterial genera, modules symptom self-reported depression. Results Associations moderate strong evidence were found for 3 genera ( Odoribacter , Anaerotruncus Alistipes ) (pectin, glycosaminoglycan central carbohydrate metabolism) regard 4 Intestinimonas Eubacterium Clostridiales g.i.s) 2 implicating amino acid metabolism Conclusions This provides first association triplets composition, function extraintestinal Depression associated lower abundances short-chain fatty producers distinct pathways glycan, metabolism. Our results suggest that microbiota-directed therapeutic approaches may reduce should be investigated future research.
Language: Английский
Citations
34
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(10), P. 3458 - 3458
Published: May 14, 2023
Fatigue, a common symptom, together with the characteristic of performance fatigability, are well-documented features SMA that impact quality life and function. Importantly, establishing associations between multidimensional self-reported fatigue scales patient has proven difficult. This review was conducted to evaluate various patient-reported applied in SMA, objective considering limitations advantages each measure. Variable use fatigue-related nomenclature, including conflicting terminology interpretation, affected assessment physical attributes, specifically perceived fatigability. encourages development original enable fatigability assessment, providing potential complementary method evaluating treatment response.
Language: Английский
Citations
17
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Sept. 4, 2023
Fatigue is barrier of physical activity participation in adults with chronic conditions. However, alleviates fatigue symptoms. This systematic review and meta-analysis aimed to (1) synthesise evidence from randomised controlled trials (RCTs) exploring the effects interventions on reduction (2) evaluate their effectiveness. Medline/CINAHL/EMBASE/Web Science Scopus were searched up June 24th, 2023. Two reviewers independently conducted study screening selection (RCTs), extracted data assessed risk bias (RoB2). Outcome was standardised mean difference (SMD) 95% confidence intervals between experimental control groups. 38 articles met inclusion criteria. Overall, moderately reduced (SMD = 0.54, p < 0.0001). Interventions lasting 2-6 weeks demonstrated a larger effect 0.86, 0.00001). 18-24 sessions showed large 0.97, Aerobic cycling combination training had moderate 0.66, 0.0005; SMD 0.60, 0.0010, respectively). No long-term found during follow-up. Physical among Duration, total sessions, mode identified as key factors intervention Further research needed explore impact fatigue.
Language: Английский
Citations
17
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 5, 2024
Background Fatigue of unknown origin is a hallmark symptom in chronic fatigue syndrome (CFS) and also found 20% hypothyroidism patients despite appropriate levothyroxine treatment. Here, we suggest that these disorders, peripheral serotonin levels are low, elevating them to normal range with L-carnitine accompanied reduced fatigue. Methods We conducted retrospective analysis follow-up clinical data (CFS N=12; N=40) where serum were compared before vs. after 7 weeks oral supplementation. Results After L-carnitine, increased (8-fold CFS, Sig. = 0.002, 6-fold hypothyroidism, < 0.001) whereas decreased (2-fold both CFS 0.002 for 0.001 hypothyroidism). There was negative correlation between level (for rho -0.49 -0.67 L-carnitine; -0.24 -0.83 L-carnitine). Conclusions These findings new link low serotonin,
Language: Английский
Citations
7