From probiotics to postbiotics: Concepts and applications

Animal Research and One Health, Journal Year: 2023, Volume and Issue: 1(1), P. 92 - 114

Published: July 3, 2023

Abstract In recent years, the important role of gut microbiota in promoting animal health and regulating immune function livestock poultry has been widely reported. The issue problems causes significant economic losses each year. Probiotics postbiotics have developed as additives due to their beneficial effects balancing host microbiota, enhancing intestinal epithelial barrier, immunity, whole‐body metabolism. are composed complex ingredients, with different components compositions having effects, requiring classification for discussing mechanisms action. considerable prospects preventing various diseases industry feed medical applications. This review highlights application value probiotics potential probiotic products, emphasizing concept, mechanism action, application, improve productivity poultry.

Language: Английский

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Intestinal bacteria associated with irritable bowel syndrome and chronic fatigue

Neurogastroenterology & Motility, Journal Year: 2023, Volume and Issue: 35(9)

Published: May 29, 2023

Abstract The etiology of irritable bowel syndrome (IBS) is unknown. Abnormal intestinal bacterial profiles and low diversity appear to play important roles in the pathophysiology IBS. This narrative review was designed present recent observations made relating fecal microbiota transplantation (FMT), which implicate possible 11 bacteria abundances nine these increased after FMT patients with IBS, increases were inversely correlated IBS symptoms fatigue severity. These Alistipes spp., Faecalibacterium prausnitzii , Eubacterium biforme Holdemanella biformis Prevotella Bacteroides stercoris Parabacteroides johnsonii zoogleoformans Lactobacillus spp. two decreased severity ( Streptococcus thermophilus Coprobacillus cateniformis ). Ten are anaerobic one ) facultative anaerobic. Several produce short‐chain fatty acids, especially butyrate, used as an energy source by large intestine epithelial cells. Moreover, it modulates immune response hypersensitivity decreases cell permeability motility. could be probiotics improve conditions. Protein‐rich diets increase abundance plant‐rich diet consequently fatigue.

Language: Английский

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Disease-State Dependent Associations Between Intrinsic Brain Function and Symptoms of Fatigue, Depression, and Anxiety in Crohn’s Disease

Inflammatory Bowel Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Background Extraintestinal symptoms (EIS) in inflammatory bowel diseases, including fatigue, depression and anxiety, are highly prevalent, but poorly understood. Alterations of brain function may contribute to EIS, their association with disease activity is unclear. This study analyzed intrinsic neural (INA) individuals Crohn’s (CD) different states examined the relationship between INA EIS. Methods Patients CD (n = 92) healthy controls 41) underwent functional magnetic resonance imaging completed symptom-specific psychometry. Temporal (amplitude low-frequency fluctuations, ALFF) spatial (regional homogeneity, ReHo) markers were compared active (patients [aCD]) versus remitted (rCD) disease. Regression analyses explored disease-state-dependent associations Results exhibited aberrant frontotemporal, occipital, thalamic regions. aCD lower ALFF left subcallosal cortex inferior temporal gyri rCD. Regional homogeneity was medial orbital gyrus higher right superior frontal, temporal, precentral gyrus. Compared rCD, showed predominantly superior, ventro-, dorsolateral prefrontal Distinct EIS detected patients, particularly state. Conclusions Intrinsic patients varies by state, prominent frontal changes These at least partly related magnitude neuropsychiatric highlight a role disturbed brain–gut interactions development especially

Language: Английский

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Effects of aerobic exercise or Tai Chi Chuan interventions on problematic mobile phone use and the potential role of intestinal flora: A multi-arm randomized controlled trial

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 170, P. 394 - 407

Published: Jan. 8, 2024

Language: Английский

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The Intertwining Roads between Psychological Distress and Gut Microbiota in Inflammatory Bowel Disease

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2268 - 2268

Published: Sept. 9, 2023

Inflammatory bowel disease represents one of the most life-altering gastrointestinal pathologies, with its multifactorial nature and unclear physiopathology. The relevant clinical forms, ulcerative colitis Crohn’s disease, clinically manifest mild to severe flares remission periods that alter patient’s social, familial professional integration. chronic inflammatory activity intestinal wall determines modifications local environment, such as dysbiosis, enteric endocrine, nervous immune system disruptions permeability changes. These features are part ecosystem modulates bottom-to-top signaling central system, leading a neurobiologic imbalance affective and/or behavioral symptoms. gut-brain link is bidirectional pathway psychological distress can also affect which will top-to-bottom regulation, possible functional digestive symptoms responses. In middle this neuro-gastrointestinal microbiome key player, activities offer basic support for both relays. present article presents current scientific information links pathophysiology aspects psychiatric symptomatology through complex mechanism axis modulatory effects gut microbiota.

Language: Английский

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Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1460 - 1460

Published: May 12, 2024

Negative emotions and gut microbiota during pregnancy both bear significant public health implications. However, the relationship between them has not been fully elucidated. This study, utilizing data from a cohort, employed metagenomic sequencing to elucidate anxiety, depression, microbiota’s diversity, composition, species, functional pathways. Data 87 subjects, spanning 225 time points across early, mid, late pregnancy, were analyzed. The results revealed that anxiety depression significantly corresponded lower alpha diversity (including Shannon entropy Simpson index). Anxiety scores, along with categorical distinctions of anxiety/non-anxiety depression/non-depression, found account for 0.723%, 0.731%, 0.651%, 0.810% variance in gut-microbiota composition (p = 0.001), respectively. Increased was positively associated abundance Oscillibacter sp. KLE 1745, PEA192, 1728, Oscillospiraceae bacterium VE202 24, Treponema socranskii. A similar association noted 1745 elevated scores. While EC.3.5.3.1: arginase appeared be higher anxious group than non-anxious group, vitamin B12-related enzymes non-depression group. changes statistically after post-multiple comparison adjustment.

Language: Английский

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Food pairing independently associated with cardiometabolic traits beyond dietary patterns across western and eastern populations

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Cardiometabolic health is closely linked to diet. Both specific food choices and dietary indices are commonly used guide cardiometabolic protection strategies. However, the balance between foods may also significantly impact health. Here, we explore imbalance in long-term intake quantify pairing patterns (FPs), providing insights beyond conventional single-food frequencies. Using data from our GGMP (n = 6,994) NHANES 7,350) cohorts, observed that independent of single frequency indices. We identified 1,759 306 cardiometabolic-related two cohorts (FDR < 0.05), respectively. Notably, around 80% these not individually associated with traits, pattern associations traits at hyper group level were consistent across Eastern Western populations. Besides, mediation analysis revealed 72.7% affected through 31 microbial genera, Clostridiumsensustricto1 playing a predominant role. Moreover, multi-step found microbes mediated on primarily their metabolic pathways, such as pyruvate fermentation propanoate ergothioneine biosynthesis pathways. Our suggest broadly by modulating gut functionalities, contrast lower occurrence when considering individual isolation. These results offer novel perspective for designing personalized strategies present enhance

Language: Английский

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Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 27, 2025

Abstract The brain-gut axis constitutes the basis for bidirectional communication between central nervous system and gastrointestinal tract driven by neural, hormonal, metabolic, immunological, microbial signals. Alterations in gut microbiome composition as observed inflammatory bowel diseases can modulate brain function emerging empirical evidence has indicated that interactions among microbiome-axis seem to play a significant role pathogenesis of both psychiatric disorders their comorbidity. Yet, immunological molecular mechanisms underlying co-occurrence psychological symptoms are still poorly understood. aim this narrative review is highlight contemporary findings supporting pivotal pathophysiology highly prevalent neuropsychiatric such fatigue, depression, anxiety. Finally, we focus on modulation potential treatment option comorbid immune-mediated especially diseases. High-quality clinical trials required clarify how through dietary interventions or probiotic, prebiotic synbiotic be used clinically improve mental health thus quality life patients with

Language: Английский

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Association of escitalopram-induced shifts in gut microbiota and sphingolipid metabolism with depression-like behavior in wistar-kyoto rats

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

The microbiota-gut-brain axis plays a pivotal role in neuropsychiatric disorders, particularly depression. Escitalopram (ESC) is first-line antidepressant, however, its regulatory mechanisms on the treatment of depression remain unclear. antidepressant effects ESC were evaluated using forced swim test Wistar-Kyoto (WKY) rats, while damage gut and brain regions was assessed through H&E staining immunohistochemistry. therapeutic WKY rats with depression-like behavior investigated 16S rRNA sequencing microbiota, serum untargeted metabolomics, hippocampal proteomics. Results indicated that intervention improved depressive-like behaviors, as evidenced by increased swimming times also restored intestinal permeability tissue integrity. Significant changes microbiota composition, an increase Bacteroides barnesiae, well increases sphingolipid metabolites (Sphinganine 1-phosphate, Sphingosine, Sphingosine-1-phosphate) proteins (Sptlc1, Enpp5, Enpp2), strongly correlated. These robust correlations suggest may exert modulating metabolism influence microbiota. Accordingly, this research elucidates novel underlying efficacy highlights importance mediating these effects.

Language: Английский

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Food pairing pattern independently associated with cardiometabolic traits beyond dietary indices across eastern and western populations

Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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