Cited by Potential of oleaginous microbes for lipid accumulation and renewable energy generation

Metabolic Engineering for Squalene Production: Advances and Perspectives DOI

Liang Chai, Jing Che,

Qingsheng Qi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Squalene is a linear polyunsaturated triterpene which has multiple physiological functions including anticancer, antioxidant, and skin-care. It been widely used in the food, medicine, cosmetics sectors also serves as precursor of triterpenes steroids. Recently, production squalene by microbial cell hosts drawn much attention due to its sustainability, environmental friendliness, great efficiency. In this review, we first introduce recent developments employing factories, especially yeasts. Next, underscore primary metabolic strategies, biosynthetic pathway engineering, manipulation, cofactor organelle engineering. addition traditional engineering discuss some prospective regulation approaches, lipid synthesis, identifying manipulating related transcription factors, dynamic pathway, secretion membrane-impermeable terpenoids. These approaches provide insights for further

Language: Английский

Citations

Novel cell factory for the production of 24-epi-ergosterol, an un-natural semi-synthetic precursor for the production of brassinolide in Yarrowia lipolytica DOI

Yuanying Wang,

S.-W. Liu,

Zheng Sheng

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(3)

Published: March 1, 2025

Language: Английский

Citations

Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications DOI

Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role cholesterol homeostasis, SQLE implicated cancer, hypercholesterolemia, and fungal infections, positioning it as valuable therapeutic target. We conducted comprehensive literature search across primary databases gather vitro, silico, vivo evidence on SQLE. This review explores enzyme's structural functional features, including substrate specificity catalytic mechanisms, examines inhibitor interactions. Computational methods predict - dynamics, guiding drug design, while investigations clarify SQLE's metabolic disorders tumorigenesis. Challenges include resistance study discrepancies, but emerging technologies, such cryo-electron microscopy CRISPR editing, offer new avenues for deeper exploration. an underexplored yet promising target, with particular relevance oxidative stress, ferroptosis, gut microbiota research. Overcoming current barriers through advanced technologies multidisciplinary strategies could propel SQLE-targeted treatments into clinical practice, supporting precision medicine broader translational applications.

Language: Английский

Citations

Potential of oleaginous microbes for lipid accumulation and renewable energy generation DOI

Yulu Yang,

Mohammed Jalalah, Saeed A. Alsareii

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(11)

Published: Oct. 3, 2024

Language: Английский

Citations