Protective Roles of Hydrogen Sulfide in Alzheimer’s Disease and Traumatic Brain Injury DOI Creative Commons
Bindu D. Paul, Andrew A. Pieper

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1095 - 1095

Published: May 13, 2023

The gaseous signaling molecule hydrogen sulfide (H2S) critically modulates a plethora of physiological processes across evolutionary boundaries. These include responses to stress and other neuromodulatory effects that are typically dysregulated in aging, disease, injury. H2S has particularly prominent role modulating neuronal health survival under both normal pathologic conditions. Although toxic even fatal at very high concentrations, emerging evidence also revealed pronounced neuroprotective for lower doses endogenously generated or exogenously administered H2S. Unlike traditional neurotransmitters, is gas and, therefore, unable be stored vesicles targeted delivery. Instead, it exerts its physiologic through the persulfidation/sulfhydration target proteins on reactive cysteine residues. Here, we review latest discoveries roles Alzheimer's disease (AD) traumatic brain injury, which one greatest risk factors AD.

Language: Английский

Near-Infrared Fluorescent Probe with Large Stokes Shift for Imaging of Hydrogen Sulfide in Tumor-Bearing Mice DOI

Ling Yan,

Qing-Song Gu,

Wen‐Li Jiang

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(14), P. 5514 - 5520

Published: April 1, 2022

Hydrogen sulfide (H2S) is an important endogenous gas signal molecule in living system, which participates a variety of physiological processes. Very recent evidence has accumulated to show that H2S closely associated with various cancers and can be regarded as biomarker cancer. Herein, we have constructed new near-infrared fluorescent probe (DCP-H2S) based on isophorone-xanthene dye for sensing hydrogen (H2S). The shows remarkable NIR turn-on at 770 nm large Stokes shift 200 nm, together high sensitivity (15-fold) rapid detection ability (4 min). also possesses excellent selectivity over other analytes including biothiols containing sulfhydryl (-SH). Moreover, DCP-H2S been successfully applied visualize exogenous cells (293T, Caco-2 CT-26 cells). In particular, the distinguish normal mice tumor shown, it expected powerful tool cancer diagnosis.

Language: Английский

Citations

116
The hormesis principle of neuroplasticity and neuroprotection DOI Creative Commons
Mark P. Mattson, Rehana K. Leak

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 315 - 337

Published: Jan. 10, 2024

Language: Английский

Citations

19
Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects DOI
Siwen Li,

Mei Shi,

Yanling Wang

et al.

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 402, P. 123933 - 123933

Published: Sept. 13, 2020

Language: Английский

Citations

112
Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases DOI Creative Commons
Rubaiya Tabassum, Na Young Jeong

International Journal of Medical Sciences, Journal Year: 2019, Volume and Issue: 16(10), P. 1386 - 1396

Published: Jan. 1, 2019

Oxidative phosphorylation is a source of energy production by which many cells satisfy their requirements.Endogenous reactive oxygen species (ROS) are by-products oxidative phosphorylation.ROS formed due to the inefficiency phosphorylation, and lead stress that affects mitochondrial metabolism.Chronic contributes onset neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS).The immediate consequences include lipid peroxidation, protein oxidation, deoxyribonucleic acid (mtDNA) mutation, induce neuronal cell death.Mitochondrial binding amyloid-β (Aβ) has been identified contributing factor in AD.In PD HD, respectively, α-synuclein (α-syn) huntingtin (Htt) gene mutations have reported exacerbate effects stress.Similarly, abnormalities dynamics respiratory chain occur ALS dysregulation complexes II IV.However, stress-induced dysfunctions diseases can be mitigated antioxidant function hydrogen sulfide (H 2 S), also acts through potassium (K ATP /K + ) ion channel calcium (Ca 2+ channels increase glutathione (GSH) levels.The pharmacological activity H S exerted both inorganic organic compounds.GSH, peroxidase (Gpx), superoxide dismutase (SOD) neutralize O -induced damage mitochondria.The main purpose this review discuss specific causes how these impacted functions support development advancements treatment.

Language: Английский

Citations

111
Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses DOI Creative Commons
Virender Kumar Pal, Parijat Bandyopadhyay, Amit Singh

et al.

IUBMB Life, Journal Year: 2018, Volume and Issue: 70(5), P. 393 - 410

Published: March 30, 2018

Abstract An increasing number of studies have established hydrogen sulfide (H 2 S) gas as a major cytoprotectant and redox modulator. Following its discovery, H S has been found to pleiotropic effects on physiology human health. acts gasotransmitter exerts influence gastrointestinal, neuronal, cardiovascular, respiratory, renal, hepatic systems. Recent discoveries clearly indicated the importance in regulating vasorelaxation, angiogenesis, apoptosis, ageing, metabolism. Contrary higher organisms, role pathophysiology infectious agents such bacteria viruses less studied. Bacterial viral infections are often accompanied by changes both host pathogen. Emerging indicate that bacterial‐derived constitutes defense system against antibiotics oxidative stress. The signaling pathway also seems interfere with redox‐based events affected infection viruses. This review aims summarize recent advances emerging bacterial infections. Such opened up new research avenues exploiting potential therapeutic intervention. © 2018 Authors IUBMB Life published Wiley Periodicals, Inc. behalf International Union Biochemistry Molecular Biology, 70(5):393–410,

Language: Английский

Citations

104
Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology DOI Creative Commons
Antonio Francioso, Alessia Baseggio Conrado, Luciana Mosca

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 27

Published: Sept. 29, 2020

Sulfur contributes significantly to nature chemical diversity and thanks its particular features allows fundamental biological reactions that no other element allows. natural compounds are utilized by all living beings depending on the function distributed in different kingdoms. It is coincidence marine organisms one of most important sources sulfur products since inorganic metabolized ocean environments where this abundant. Terrestrial such as plants microorganisms also able incorporate organic molecules produce primary metabolites (e.g., methionine, cysteine) more complex unique structures with diverse roles. Animals not fix into biomolecules completely dependent preformed sulfurous satisfy their needs. However, some higher species humans build new sulfur-containing entities starting especially from plants’ organosulfur precursors. metabolism very complicated plays a central role redox biochemistry. The properties, large number oxidation states, versatile reactivity oxygen family chalcogens make ideal for electron transfer processes. This review will explore related biochemistry describe various classes spread over We chemistry well-known unknown poorly studied which still search role.

Language: Английский

Citations

94
Metal-organic framework (MOF)-based advanced sensing platforms for the detection of hydrogen sulfide DOI
Kumar Vikrant, Vanish Kumar, Yong Sik Ok

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2018, Volume and Issue: 105, P. 263 - 281

Published: May 30, 2018

Language: Английский

Citations

90
Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells DOI

Fiona Augsburger,

Csaba Szabó

Pharmacological Research, Journal Year: 2018, Volume and Issue: 154, P. 104083 - 104083

Published: Nov. 27, 2018

Language: Английский

Citations

87
Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases DOI Creative Commons
Yuyi Han,

Qianwen Shang,

Jin Yao

et al.

Cell Death and Disease, Journal Year: 2019, Volume and Issue: 10(4)

Published: March 29, 2019

Hydrogen sulfide (H

Language: Английский

Citations

86
Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms DOI Creative Commons
Ángeles Aroca, Jing Zhang,

Yanjie Xie

et al.

Journal of Experimental Botany, Journal Year: 2021, Volume and Issue: 72(16), P. 5893 - 5904

Published: May 24, 2021

Hydrogen sulfide (H2S) is a signaling molecule that regulates critical processes and allows plants to adapt adverse conditions. The molecular mechanism underlying H2S action relies on its chemical reactivity, the most-well characterized persulfidation, which involves modification of protein thiol groups, resulting in formation persulfide groups. This causes change function, altering catalytic activity or intracellular location inducing important physiological effects. cannot react directly with thiols but instead can oxidized cysteine residues; therefore, H2O2 through sulfenylation required for persulfidation. A comparative study performed this review reveals 82% identity between sulfenylome persulfidome. With regard abscisic acid (ABA) signaling, widespread evidence shows an interconnection ABA plant response environmental stress. Proteomic analyses have revealed persulfidation several proteins involved network shown triggered ABA. In guard cells, complex interaction has also been described, specific components seems be mechanism.

Language: Английский

Citations

75