Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

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Recent advances in small-molecule fluorescent probes for diagnosis of cancer cells/tissues

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 477, P. 214946 - 214946

Published: Dec. 9, 2022

Language: Английский

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Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(7), P. 4124 - 4257

Published: March 21, 2024

Hydrogen sulfide (H2S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H2S often classified as "gasotransmitter," meaning that it endogenously produced membrane permeable carries out essential cellular processes. Fluorescent probes for and related reactive sulfur species (RSS) detection provide cornerstone investigating the multifaceted roles these molecules complex biological systems. A now common approach to develop such tools "activity-based probes" couple specific H2S-mediated chemical reaction fluorescent output. This Review covers different types highlights mechanisms by which each probe type activated RSS. Common examples include reduction oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, coordination. addition, we outline complementary activity-based imaging reductant-labile sulfane species, including persulfides polysulfides. For highlighted this Review, focus on systems with demonstrated compatibility or applications. Building from breadth reported strategies application, highlight key unmet challenges future opportunities advancing

Language: Английский

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Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 489, P. 215193 - 215193

Published: May 6, 2023

Language: Английский

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Dual-locking fluorescent nanoprobes for HAase-triggered carbon monoxide imaging in living cells

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 394, P. 134421 - 134421

Published: Aug. 7, 2023

Language: Английский

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Near-Infrared Fluorescence Probe with a New Recognition Moiety for the Specific Detection of Cysteine to Study the Corresponding Physiological Processes in Cells, Zebrafish, and Arabidopsis thaliana

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(15), P. 6030 - 6036

Published: April 3, 2024

Cysteine (Cys), as one of the biological thiols, is related to many physiological and pathological processes in humans plants. Therefore, it necessary develop a sensitive selective method for detection imaging Cys organisms. In this work, novel near-infrared (NIR) fluorescent probe, Probe-Cys, was designed by connecting furancarbonyl, new recognition moiety, with Fluorophore–OH via decomposition IR-806. The use furan moiety anticipated produce more effective fluorescence quenching because electron-donating ability O atom. Probe-Cys has outstanding properties, such group, an emission wavelength infrared region at 710 nm, linear range (0–100 μM), low limit 0.035 μM, good water solubility, excellent sensitivity, selectivity without interference Hcy, GSH, HS–. More importantly, could achieve endogenous reacting stimulant 1,4-dimercaptothreitol (DTT) inhibitor N-ethylmaleimide (NEM) HepG2 cells zebrafish. Ultimately, successfully applied obtain images Arabidopsis thaliana, revealing that content meristematic zone higher than elongation zone, which first time NIR probe used A. thaliana. superior properties exhibit its great potential biosystems explore associated Cys.

Language: Английский

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Dihydroxanthene-Based Near-infrared Fluorescent Probes for Monitoring Mitochondrial Viscosity in Living Cells and Mice

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(6), P. 3544 - 3549

Published: Feb. 6, 2023

Aberrant mitochondrial viscosity is closely associated with many diseases and cellular malfunctions. Thus, the development of reliable methods for monitoring variations has attracted considerable attention. Herein, through stepwise structural modulation dihydroxanthene fluorophore (DHX), we developed three NIR fluorescent probes, named DHX-V-1-3, detecting viscosity. Among them, DHX-V-3 displayed highest signal-to-noise ratio (67-fold) outstanding selectivity showed excellent mitochondria targeting immobilization ability. At level, probe was successfully applied to image in live cells upon treatment lipopolysaccharide (LPS) or nystatin. Moreover, benefiting from its emission increased depth tissue imaging, demonstrated ability visualize LPS-treated mice.

Language: Английский

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Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1252, P. 341009 - 341009

Published: March 1, 2023

Language: Английский

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Dual-channel fluorescent probe for simultaneously detecting H2S and viscosity/polarity and its application in non-alcoholic fatty liver, tumor tissue, and food spoilage

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 397, P. 134596 - 134596

Published: Sept. 9, 2023

Language: Английский

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Gold Nanocluster-Based Ratiometric Probe with Surface Structure Regulation-Triggered Sensing of Hydrogen Sulfide in Living Organisms

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(10), P. 12643 - 12652

Published: March 1, 2023

The development of reliable probes for in vivo detection hydrogen sulfide (H2S) with high sensitivity and selectivity is great significance due to its key roles many pathological physiological processes. Herein, it was found that H2S could finely regulate surface structure gold nanoclusters (AuNCs) through reduction Au(I)-ligand motifs further quench their fluorescence by a two-stage kinetic reaction process. Stage I showed the H2S-assisted Au(0) core growth rapid decrease; stage II optimization reconstruction relatively slow quenching. By virtue excellent response AuNCs H2S, novel ratiometric probe (RBDA) sensing designed electrostatic attraction-induced resonance energy transfer (FRET) between rhodamine B. facilely prepared, showing straightforward, built-in self-calibration. It presented limit (LOD) 56 nM an over various other biological species. demonstrated possess biostability, low cytotoxicity, good cell issue penetrability, favorable biocompatibility. realizes successful monitoring both exogenous endogenous levels living cells zebrafish.

Language: Английский

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