Circadian Effects of Drug Responses DOI Creative Commons
Yaakov Nahmias, Ioannis P. Androulakis

Annual Review of Biomedical Engineering, Journal Year: 2021, Volume and Issue: 23(1), P. 203 - 224

Published: March 31, 2021

Circadian rhythms describe physiological systems that repeat themselves with a cycle of approximately 24 h. Our understanding the cellular and molecular origins these oscillations has improved dramatically, allowing us to appreciate significant role play in maintaining homeostasis. allow living organisms predict efficiently respond dynamically changing environment, set by repetitive day/night cycles. Since circadian underlie almost every aspect human physiology, it is unsurprising they also influence response organism disease, stress, therapeutics. Therefore, not only do mechanisms maintain health disrupt homeostasis depend on our internal clock, but way drugs are perceived function depends rhythms. We present holistic view therapeutic process, discussing components such as disease state, pharmacokinetics, pharmacodynamics, well adverse reactions critically affected outline challenges opportunities moving toward personalized medicine approaches explore capitalize for benefit patient.

Language: Английский

The Relationship between Circadian Rhythm and Cancer Disease DOI Open Access
Camelia Munteanu,

Sabina Turti,

Larisa Achim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

Citations

12
Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms DOI Creative Commons
Farheen S. Shaikh, Ruby J. Siegel,

Aayush Srivastava

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

MicroRNAs (miRNAs) are small non-coding RNAs that alter the expression of target genes at post-transcriptional level, influencing diverse outcomes in metabolism, cell differentiation, proliferation, survival, and death. Dysregulated miRNA is implicated various rheumatic conditions, including ankylosing spondylitis (AS), gout, juvenile idiopathic arthritis (JIA), osteoarthritis (OA), psoriatic arthritis, rheumatoid (RA), Sjogren’s syndrome, systemic lupus erythematosus (SLE) sclerosis. For this review, we used an open-source programming language- PowerShell, to scan massive number existing primary research publications on PubMed miRNAs these nine diseases identify count unique co-occurrences individual disease name. These counts were rank top seven most relevant immuno-miRs based their volume each disease. Individual also screened for publication with names immune cells, cytokines, pathological processes involved diseases. occurrences tabulated into matrices hotspots relevance. Based information, summarize basic clinical findings three — miR-146, miR-155, miR-21 whose relevance spans across multiple Furthermore, highlight some why conditions lack emerging epigenetics field. With overwhelming diseases, review serves as a ‘relevance finder’ guide researchers selecting compiled knowledge involvement pathogenesis. This approach applies other contexts end goal developing miRNA-based therapeutics.

Language: Английский

Citations

11
Chrono-tailored drug delivery systems: recent advances and future directions DOI Creative Commons

Christine T. Butler,

Aoife M. Rodgers, Annie M. Curtis

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(7), P. 1756 - 1775

Published: Feb. 28, 2024

Abstract Circadian rhythms influence a range of biological processes within the body, with central clock or suprachiasmatic nucleus (SCN) in brain synchronising peripheral clocks around body. These are regulated by external cues, most influential being light/dark cycle, order to synchronise day. Chrono-tailored circadian drug delivery systems (DDS) aim optimise releasing drugs at specific times day align Although this approach is still relatively new, it has potential enhance efficacy, minimise side effects, and improve patient compliance. DDS have been explored implemented various conditions, including asthma, hypertension, cancer. This review aims introduce biology provide an overview current research on chrono-tailored DDS, particular focus immunological applications vaccination. Finally, we draw some key challenges which need be overcome for before they can translated more widespread use clinical practice. Graphical

Language: Английский

Citations

11
The role of circadian clock in regulating cell functions: implications for diseases DOI Creative Commons

Yanke Lin,

Liangliang He, Yuting Cai

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental internal oscillations. Disruptions in rhythms have been linked increased susceptibility various diseases can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression cell function by clocks across diverse tissues. . Specifically, we explore rhythmicity expressions, behaviors, functions both immune non‐immune cells, elucidating regulatory effects mechanisms imposed clocks. A detailed discussion is centered on complex regulating key cellular signaling pathways. We further diseases, with a focus inflammatory cancers, systemic diseases. By highlighting intimate interplay between especially through clock‐controlled function, this contributes development novel disease intervention strategies. enhanced understanding holds significant promise for design targeted therapies that exploit improved treatment efficacy.

Language: Английский

Citations

10
Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity DOI

Zedong Xiang,

Huida Guan, Xiang Zhao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155444 - 155444

Published: Feb. 10, 2024

Language: Английский

Citations

9
Daily multi-segment capsule for time-tunable drug release toward enhanced polypharmacy adherence DOI
Amal Abbas,

Janna Sofia Sage-Sepulveda,

Kuldeep Mahato

et al.

Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101947 - 101947

Published: Jan. 14, 2025

Language: Английский

Citations

1
Time of day as a critical variable in biology DOI Creative Commons
Randy J. Nelson, Jacob R. Bumgarner, Jennifer A. Liu

et al.

BMC Biology, Journal Year: 2022, Volume and Issue: 20(1)

Published: June 15, 2022

Abstract Background Circadian rhythms are important for all aspects of biology; virtually every aspect biological function varies according to time day. Although this is well known, variation across the day also often ignored in design and reporting research. For review, we analyzed top 50 cited papers 10 major domains sciences calendar year 2015. We repeated analysis 2019, hypothesizing that awarding a Nobel Prize 2017 achievements field circadian biology would highlight importance scientists many disciplines, improve time-of-day reporting. Results Our analyses these 1000 empirical papers, however, revealed most failed include sufficient temporal details when describing experimental methods few systematic differences existed between 2015 2019. Overall, only 6.1% reports included information about measures manipulations permit replication. Conclusions defining feature systems, knowing systems evaluated fundamentally information. Failing account hampers reproducibility laboratories, complicates interpretation results, reduces value data based predominantly on nocturnal animals extrapolating diurnal humans.

Language: Английский

Citations

32
Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies DOI Creative Commons
Fang Cheng, Ruoqi Zhang, Chen Sun

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 1, 2023

Oxaliplatin-based chemotherapy is a standard treatment approach for colorectal cancer (CRC). However, oxaliplatin-induced peripheral neurotoxicity (OIPN) severe dose-limiting clinical problem that might lead to interruption. This neuropathy may be reversible after discontinuation. Its complicated mechanisms are related DNA damage, dysfunction of voltage-gated ion channels, neuroinflammation, transporters, oxidative stress, and mitochondrial dysfunction, etc. Several strategies have been proposed diminish OIPN without compromising the efficacy adjuvant therapy, namely, combination with chemoprotectants (such as glutathione, Ca/Mg, ibudilast, duloxetine, ), chronomodulated infusion, dose reduction, reintroduction oxaliplatin topical administration [hepatic arterial infusion (HAIC), pressurized intraperitoneal aerosol (PIPAC), hyperthermic (HIPEC)]. article provides recent updates potential mechanisms, therapeutic in OIPN, pharmacokinetics several methods trials.

Language: Английский

Citations

17
Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology DOI Open Access
Nicolas G. Nelson, Joseph Lombardo,

Lauren Matlack

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1331 - 1331

Published: Jan. 25, 2022

Circadian disruption has been linked to cancer development, progression, and radiation response. Clinical evidence date shows that circadian genetic variation time of treatment affect response toxicity for women with breast cancer. At the molecular level, there is interplay between clock regulators such as PER1, which mediates ATM p53-mediated cell cycle gating apoptosis. These alterations may govern aggressive phenotypes, outcomes, Exploiting various mechanisms enhance therapeutic index by decreasing toxicity, increasing disease control, improving outcomes. We will review body's natural rhythms gene-regulation while exploring preclinical clinical implicates chronobiological disruptions in etiology discuss radiobiological principles regulation DNA damage responses. Lastly, we present potential rational approaches target pathways improve outcomes Understanding implications optimal timing ways entrain biology light, diet, agents like melatonin provide an avenue enhancing radiotherapy.

Language: Английский

Citations

25
A new time dimension in the fight against metastasis DOI
Zoi Diamantopoulou, Ana Gvozdenovic, Nicola Aceto

et al.

Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 33(9), P. 736 - 748

Published: March 24, 2023

Language: Английский

Citations

14