Published: Aug. 15, 2022
CCTcarcinoma de células transicionais cDNA DNA codificante CFSE
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
2
Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 91, P. 99 - 109
Published: March 7, 2023
The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a central and peripheral clock, which influences the cycles activities sleep individual over 24 h. At molecular level, begins when two basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins, BMAL-1 CLOCK, interact with each other to produce BMAL-1/CLOCK heterodimers in cytoplasm. target genes encode for repressor components cryptochrome (Cry1 Cry2) Period proteins (Per1, Per2 Per3). It has been recently demonstrated that disruption associated increased risk developing obesity obesity-related diseases. In addition, it plays key role tumorigenesis. Further, association between disruptions incidence progression several types cancer (e.g., breast, prostate, colorectal thyroid cancer) found. As perturbation adverse metabolic consequences obesity) at same time tumor promoter functions, this manuscript aim report how aberrant rhythms affect development prognosis different cancers (breast, colon rectal focusing on human studies aspects.
Language: Английский
Citations
34
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 30, 2024
Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected
Language: Английский
Citations
6
Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 575 - 575
Published: Feb. 8, 2025
We investigated the transcription of circadian clock genes in publicly available datasets gene expression medulloblastoma (MB) tissues using R2 Genomics Analysis and Visualization Platform. Differential core among four consensus subgroups MB (defined 2012 as Group 3, 4, SHH group, WNT group) included (CLOCK, NPAS2, PER1, PER2, CRY1, CRY2, BMAL1, BMAL2, NR1D1, TIMELESS) which encode proteins that regulate (CIPC, FBXL21, USP2). The over-expression several genes, including CIPC, was found individuals with isochromosome 17q chromosomal aberration 3 4. most significant biological pathways associated were ribosome subunits, phototransduction, GABAergic synapse, signaling pathway, Fanconi anemia pathway. Survival analysis examined Kaplan-Meier method Cox proportional hazards regression model through Two significantly related to survival CRY1 USP2. data suggest proteins, USP2, be potential therapeutic targets MB.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 732 - 732
Published: Feb. 21, 2025
In the era of precision medicine, mounting evidence suggests that time therapy administration, or chronotherapy, has a great impact on treatment outcomes. Chronotherapy involves planning timing by considering circadian rhythms, which are 24 h oscillations in behavior and physiology driven synchronized molecular clocks throughout body. The value chronotherapy cancer is currently under investigation, notably effects efficacy side effects. Immune checkpoint inhibitor (ICI) promising treatment. However, many patients still experience disease progression need to stop early due There accumulating day at ICI administered can have substantial effect efficacy. Thus, it important investigate intersections this review, we provide brief overview rhythms context immunity cancer. Additionally, outline current applications for We synthesize 29 studies conducted date examine time-of-day administration therapy, its associated effects, sex differences both also discuss potential mechanisms underlying these observed results. Finally, highlight challenges area future directions research, including chronotherapeutic personalized medicine approach tailors individual patients’ rhythms.
Language: Английский
Citations
0
STUDIES IN HEALTH SCIENCES, Journal Year: 2025, Volume and Issue: 6(1), P. e14781 - e14781
Published: March 14, 2025
Os ritmos ultradianos são ciclos biológicos menores que 24 horas regulam a secreção pulsátil de hormônios essenciais para homeostase metabólica, incluindo insulina, cortisol e hormônio do crescimento. Esses influenciam diretamente o metabolismo energético, resposta inflamatória regulação da glicose. Sua desregulação tem sido associada doenças endócrinas, como diabetes tipo 2, obesidade distúrbios tireoidianos. Este estudo realizou uma revisão integrativa literatura analisar relação entre metabolismo, avaliando sua influência na hormonal no desenvolvimento metabólicas. A incluiu pesquisas extraídas bases dados científicas PubMed, LILACS, Scopus, Web of Science Embase, considerando artigos publicados nos últimos 10 anos. análise dos estudos revelou perda regularidade compromete funcionalidade osciladores hormonais centrais periféricos, resultando em metabólicos severos. Além disso, fatores padrões alimentares irregulares privação sono contribuem desses hormonais. achados desta destacam importância cronobiologia prevenção tratamento endócrinas. Estratégias terapêuticas baseadas modulação ultradianos, cronoterapia ajuste alimentação ciclo sono, mostraram-se eficazes restauração equilíbrio metabólico. No entanto, mais necessários desenvolver abordagens personalizadas otimizem sincronização promovam melhor qualidade vida indivíduos com endócrinos.
Citations
0
JCO Precision Oncology, Journal Year: 2025, Volume and Issue: 9
Published: Jan. 1, 2025
PURPOSE Chronoradiobiology has emerged as a potential field of study with therapeutic implications for cancer treatment. We aimed to investigate the association between radiation chronotherapy and efficacy toxicity patients nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS Patients nonmetastatic NPC treated intensity-modulated radiotherapy in Fujian Cancer Hospital January 2017 December 2019 were included. Propensity score matching (PSM) 1:1:1 was used account selection bias. Cox regression analysis performed explore impact timing on patient survival. Sensitivity implemented determine size directional stability. RESULTS One thousand forty met inclusion criteria 332 included PSM cohort. In unmatched cohort analysis, morning exhibited significantly superior overall survival (OS) outcome (hazard ratio [HR], 0.60 [95% CI, 0.40 0.91], adjusted log-rank P = .028) than afternoon one. After it observed that individuals undergoing group (HR, 5.88 2.55 13.58], .004) night 4.81 1.91 12.11], .018) displayed tendency toward shorter OS compared group. No significant differences acute treatment-related adverse effects among three groups. Morning demonstrated consistent robustness multivariable thereby establishing an higher OS. The directionality effect across sensitivity analysis. CONCLUSION These results underscore benefits scheduling management, although prospective studies are needed confirm these findings.
Language: Английский
Citations
0
Published: Jan. 24, 2024
Background: The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assesses timing's impact on whole-brain radiotherapy outcomes in brain metastases personalized therapy insights. Aim: Evaluate influence radiation timing its correlation with clinical outcomes. Identify patient populations benefiting from interventions synchronizing rhythms, considering subgroup differences potential disparities related to social determinants of health (SDoH). Design: IRB-approved retrospective analysis 237 patients undergoing (2017–2021), receiving over 80% treatments the morning or afternoon. Survival analyses utilized Kaplan–Meier curves. Setting/Participants: Single-institution involving radiotherapy. Collected demographic, disease, socioeconomic parameters electronic medical records. Results: Morning (n=158) showed trend towards improved overall survival vs. afternoon (n=79), median 158 79 days (p=0.20, HR=0.84, CI95% 0.84–0.91). Subgroup benefits females (p=0.04) trends controlled primary disease (p=0.11) breast (p=0.08). SDoH-based observed, Black lower-income exhibiting diminished influence. Conclusions: Emphasizes chronobiological factors' relevance therapy. correlates survival, particularly specific subgroups. Identifies based SDoH, laying foundation rhythms enhanced efficacy.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9105 - 9105
Published: Aug. 14, 2022
Metabolic dysregulation as a reflection of specific metabolite production and its utilization is common feature many human neoplasms. Melatonin, an indoleamine that highly available during darkness, has variety metabolic functions in solid tumors. Because plasma metabolites undergo circadian changes, we investigated the role melatonin on profile amino acids (AAs), biogenic amines, carnitines, sphingolipids, hexoses present mice bearing xenograft triple negative breast cancer (MDA-MB-231 cells) over 24 h. Plasma concentrations nine AAs were reduced by melatonin, especially light phase, with closer to non-breast (BC) animals. With respect acylcarnitine levels, 12 out molecules BC-bearing animals compared their controls, at 06:00 h 15:00 Importantly, asymmetric dimethylarginine, carnosine, histamine, kynurenine, methionine sulfoxide, putrescine, spermidine, spermine, symmetric which are associated BC sets. Melatonin also led levels sphingomyelins hexoses, showed distinct daily variations These results highlight controlling xenografts, may impact bioenergetics, addition emphasizing need for more accurate examination metabolomic changes different time points.
Language: Английский
Citations
8
Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)
Published: Sept. 23, 2024
The role of chronoradiobiology in nasopharyngeal carcinoma (NPC) has not been fully elucidated. We sought to investigate the impact radiotherapy rhythm on survival outcomes individuals explore a chronomodulated radiation strategy improve prognosis NPC.
Language: Английский
Citations
1