Advances in the roles of ATF4 in osteoporosis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115864 - 115864

Published: Nov. 9, 2023

Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and enhanced fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, glycolipid metabolism. ATF4 induces the differentiation of marrow mesenchymal stem cells (BM-MSCs) into osteoblasts, increases osteoblast activity, inhibits osteoclast formation, promoting formation remodeling. In addition, mediates energy metabolism osteoblasts promotes angiogenesis. also involved mediation adipogenesis. can selectively accumulate osteoblasts. directly interact with RUNT-related 2 (RUNX2) up-regulate expression osteocalcin (OCN) osterix (Osx). Several upstream factors, such as Wnt/β-catenin BMP2/Smad signaling pathways, have been ATF4-mediated differentiation. osteoclastogenesis mediating receptor activator nuclear κ-B (NF-κB) ligand (RANKL) signaling. agents, parathyroid (PTH), melatonin, natural compounds, reported to regulate mediate this review, we comprehensively discuss biological activities maintaining homeostasis inhibiting OP development. has become therapeutic target for treatment.

Language: Английский

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Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials

Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100834 - 100834

Published: Oct. 20, 2023

Achieving precision treatment in bone tissue engineering (BTE) remains a challenge. Photothermal therapy (PTT), as form of therapy, has been extensively investigated for its safety and efficacy. It demonstrated significant potential the orthopedic diseases such tumors, postoperative infections osteoarthritis. However, high temperatures associated with PTT can lead to certain limitations drawbacks. In recent years, researchers have explored use biomaterials mild photothermal (MPT), which offers promising approach addressing these limitations. This review provides comprehensive overview mechanisms underlying MPT presents compilation agents their utilization strategies repair. Additionally, paper discusses future prospects MPT-assisted regeneration, aiming provide insights recommendations optimizing material design this field.

Language: Английский

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Notch signaling pathway: a new target for neuropathic pain therapy

The Journal of Headache and Pain, Journal Year: 2023, Volume and Issue: 24(1)

Published: July 15, 2023

Abstract The Notch gene, a highly evolutionarily conserved was discovered approximately 110 years ago and has been found to play crucial role in the development of multicellular organisms. receptors their ligands are single-pass transmembrane proteins that typically require cellular interactions proteolytic processing facilitate signal transduction. Recently, mounting evidence shown aberrant activation is correlated with neuropathic pain. signaling pathway can cause neuroglia release pro-inflammatory factors, key mechanism Moreover, may contribute persistence pain by enhancing synaptic transmission calcium inward flow. This paper reviews structure pathway, as well its potential mechanisms action, provide novel insights for future treatments

Language: Английский

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NOTCH1, 2, and 3 RECEPTORS ENHANCE OSTEOBLASTOGENESIS OF MESENCHYMAL C3H10T1/2 CELLS AND INHIBIT THIS PROCESS IN PREOSTEOBLASTIC MC3T3-E1 CELLS

Differentiation, Journal Year: 2025, Volume and Issue: unknown, P. 100837 - 100837

Published: Jan. 1, 2025

Language: Английский

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Relationships among osteoporosis, redox homeostasis, and alcohol addiction: Importance of the brain-bone axis

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118063 - 118063

Published: April 19, 2025

Language: Английский

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Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117490 - 117490

Published: Sept. 26, 2024

Language: Английский

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Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115884 - 115884

Published: Nov. 17, 2023

Degenerative musculoskeletal disorders are a group of age-related diseases the locomotive system that severely affects patient's ability to work and cause adverse sequalae such as fractures even death. The incidence prevalence degenerative is rising owing aging world's population. Notch signaling pathway, which expressed in almost all organ systems, extensively regulates cell proliferation differentiation well cellular fate. shows increased activity retards progression degeneration some extent. review focuses on four major (osteoarthritis, intervertebral disc degeneration, osteoporosis, sarcopenia) summarizes pathophysiological functions these disorders, especially its role stem/progenitor cells each disorder. Finally, conclusion will be presented explore research application perspectives disorders.

Language: Английский

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Screening of SNP Loci Related to Leg Length Trait in Leizhou Goats Based on Whole-Genome Resequencing

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12450 - 12450

Published: Nov. 20, 2024

Leizhou goats can be classified into tall and short types based on their size habits. The are well-suited for grazing management due to robust physique, while the dwarf smaller, grow rapidly, more appropriate feeding systems. In this study, whole-genome resequencing was conducted identify genomic variants in 15 Tall-legged (TL) Short-legged (SL) goats, yielding 8,641,229 high-quality SNPs goat genome. Phylogenetic tree principal component analyses revealed obvious genetic differentiation between two groups. Fst θπ identified 420 genes TL group 804 SL group. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway indicated that phosphatidylinositol signaling system is associated with growth development. Additionally, Genome-Wide Association Study (GWAS) analysis eight linked leg length, including

Language: Английский

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Effect of Zika virus on the osteogenic capacity of mesenchymal stem cells via the Notch signaling pathway

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

Background: Zika virus is a small enveloped flavivirus transmitted through the bite of aedes mosquitos. Epidemiologic survey has shown that diseases caused by mainly include microcephaly and malformation cranial bones.In 2016, nucleic acid screening for zika was conducted in Puerto Rico, results indicated seasonal incidence rate could reach 21.1%. Research Purpose: To investigate effect on osteogenic capacity mesenchymal stem cells. Method: We induced virus-infected human cells into osteoblasts. Real-time quantitative polymerase chain reaction Western Blot were used to detect mRNA protein expression markers, as well notch signaling pathway molecules. A γ-secretase inhibitor explore whether ability restored after inhibiting pathway. Establish mouse model verify vivo. Result: found activated Notch cells,hindering formation After treating with gamma-secretase inhibitor,the can be restored. The same observed model. Conclusion: suppresses via

Language: Английский

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Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 12921 - 12932

Published: July 4, 2024

Marine microalgae serve as an aquaculture bait. To enhance algal cell growth and breeding profits, high-intensity light conditions are standard for cultivating bait microalgae, potentially altering microalgal metabolite production. This research revealed that

Language: Английский

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