Anilino-1,4-naphthoquinones as potent mushroom tyrosinase inhibitors: in vitro and in silico studies DOI Creative Commons

Sahachai Sabuakham,

Sutita Nasoontorn,

Napat Kongtaworn

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: May 30, 2024

Tyrosinase, a pivotal enzyme in melanin synthesis, is primary target for the development of depigmenting agents. In this work, vitro and silico techniques were employed to identify novel tyrosinase inhibitors from set 12 anilino-1,4-naphthoquinone derivatives. Results mushroom activity assay indicated that, among derivatives, three compounds (1, 5, 10) demonstrated most significant inhibitory against tyrosinase, surpassing effectiveness kojic acid. Molecular docking revealed that all studied derivatives interacted with copper ions amino acid residues at active site. dynamics simulations provided insights into stability enzyme–inhibitor complexes, which 1, particularly 10 displayed greater stability, atomic contacts, structural compactness than Drug likeness prediction further strengthens potential anilino-1,4-naphthoquinones as promising candidates treatment hyperpigmentation disorders.

Language: Английский

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier DOI
M H Miran Beygi, Fatemeh Oroojalian, Soheil Azizi‐Arani

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 4, 2024

Abstract The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent that regulates the transport various materials substances between blood vasculature central nervous (CNS). However, in cases brain diseases, BBB's protective regulatory effects hamper therapeutics from reaching affected sites sufficient quantities. This has so far been leading challenge treating CNS diseases disorders. For this problem to be overcome, recent research sought develop novel modalities achieve efficient therapy alleviate associated symptoms. Therefore, numerous strategies have operated years address limitations traditional invasive methods, including poor penetration serious side effects. As desperately in‐demand technology, nanotheranostics particularly shown promising results. Herein, review reports advancements techniques nanotechnology‐based developed for neurodegenerative study provides comprehensive data on subject used future studies management disorders diseases.

Language: Английский

Citations

24
Inhibition potential of n‐hexadecanoic and oleic acids from edible insects against α‐glucosidase, α‐amylase, tyrosinase, and acetylcholinesterase: in vitro and in silico studies DOI Open Access
Kanokorn Wechakorn, Apirak Payaka,

Jintana Masoongnoen

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract BACKGROUND Edible insects are used for consumption and traditional medicine due to their rich bioactive compounds. This study examined the compounds inhibitory effects of crude extracts from Bombyx mori Omphisa fuscidentalis on α ‐glucosidase, ‐amylase, acetylcholinesterase (AChE), tyrosinase. Fatty acids, including n ‐hexadecanoic acid oleic acid, were identified in evaluated potential against enzymes vitro silico . RESULTS The total phenolic content edible insect correlated with enzyme activity. quercetin kaempferol B ethyl acetate (EtOAc) extract was also closely related ‐amylase EtOAc hexane showed similar inhibition acarbose tacrine AChE, respectively. O exhibited comparable tyrosinase activity kojic acid. ‐Hexadecanoic predominant all extracts. A kinetic revealed that acted as a mixed‐type inhibitor acarbose, whereas non‐competitive unlike tacrine. Docking studies suggested these fatty acids bind active sites AChE. CONCLUSION findings suggest could be candidates treating diabetes mellitus Alzheimer's disease. An animal model might further examination confirm findings. © 2025 Society Chemical Industry.

Language: Английский

Citations

1
Functional Evaluation of Laminarin Butyl Esters: Antioxidant, Skin-Whitening, and Anti-Wrinkle Properties DOI
Kit‐Leong Cheong, Keying Liu, Suresh Veeraperumal

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Investigation on the inhibition mechanism and binding behavior of paeonol to tyrosinase and its anti-browning property by multi-spectroscopic and molecular docking methods DOI

Xiaofeng Min,

Li Lu, Xuetao Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126962 - 126962

Published: Sept. 16, 2023

Language: Английский

Citations

20
Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy DOI
M H Miran Beygi, Fatemeh Oroojalian, Seyed Samad Hosseini

et al.

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 140, P. 101209 - 101209

Published: Nov. 3, 2023

Language: Английский

Citations

19
Inhibitory Effects of Polyphenols from Equisetum ramosissimum and Moringa peregrina Extracts on Staphylococcus aureus, Collagenase, and Tyrosinase Enzymes: In vitro Studies DOI

Haya K. Mukattash,

Reem Issa,

Maha N. Abu Hajleh

et al.

Jordan Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 17(3), P. 530 - 548

Published: Sept. 24, 2024

Background: Skin problems caused by oxidative stress lead to the activation of collagenase and tyrosinase enzymes, contributing skin aging, discoloration, infections. Equisetum ramosissimum Moringa peregrina were assessed for their potential uses in treating various conditions. Objective: The present research aimed investigate positive effects polyphenols extracts as cosmetic products treatment different Methods: Total phenolic flavonoid contents, antioxidants, anti-collagenase anti-tyrosinase activities plant extract mixtures (PEM) at ratios (M. peregrina: E. ramosissimum) determined using standard procedures. Inhibitory PEM against acne-causing Staphylococcus aureus (ATCC 29213) evaluated diameter (cm) inhibition zone method. A cream formulation containing was developed characterized stability irritation rats Results: a ratio (2:1) showed highest total content (150.15 ± 2.8 mg/g, equivalent gallic acid, 41.5 1.2 quercetin, respectively). Antioxidant also optimal, DPPH ABTS methods (IC50 = 7.06 0.12 µg/mL 53.29 3.3 µg/mL, Furthermore, exhibited superior inhibitory enzymes 32.4 1.19 8.4 Antimicrobial activity tested on S. largest growth (2.8 cm) concentration 60 mg/mL. Studies revealed that it remained stable under room tests no signs oedema or erythema after treatment. Conclusion: with demonstrated optimal an stress-neutralizing agent, inhibitor responsible aging hyperpigmentation, antibacterial agent. physical detectable risk throughout

Language: Английский

Citations

8
Artificial Intelligence-Assisted Optimization of Antipigmentation Tyrosinase Inhibitors: De Novo Molecular Generation Based on a Low Activity Lead Compound DOI
Hong Cai,

Wenchao Chen,

Jing Jiang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(9), P. 7260 - 7275

Published: April 23, 2024

Artificial intelligence (AI) de novo molecular generation is a highly promising strategy in the drug discovery, with deep reinforcement learning (RL) models emerging as powerful tools. This study introduces fragment-by-fragment growth RL forward and optimization based on low activity lead compound. process integrates fragment growth-based reaction templates, while target docking drug-likeness prediction were simultaneously performed. comprehensive approach considers similarity, internal diversity, synthesizability, effectiveness, thereby enhancing quality efficiency of generation. Finally, series tyrosinase inhibitors generated synthesized. Most compounds exhibited more improved than lead, an optimal candidate compound surpassing effects kojic acid demonstrating significant antipigmentation zebrafish model. Furthermore, metabolic stability studies indicated susceptibility to hepatic metabolism. The proposed AI structural strategies will play role accelerating discovery improving traditional efficiency.

Language: Английский

Citations

5
Elderberry Leaves with Antioxidant and Anti-Inflammatory Properties as a Valuable Plant Material for Wound Healing DOI Creative Commons
Elżbieta Studzińska-Sroka, Magdalena Paczkowska-Walendowska,

Zuzanna Woźna

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 618 - 618

Published: May 10, 2024

Sambuci folium (elderberry leaves) have been used in traditional medicine, mainly externally, to treat skin diseases and wounds. Therefore, the aim of this study was screen biological activity elderberry leaves (antioxidant potential possibility inhibition tyrosinase hyaluronidase enzymes) combined with phytochemical analysis. For purpose, a analysis carried out. Elderberry 12 varieties (“Sampo”, “Obelisk”, “Dwubarwny”, “Haschberg”, “Haschberg 1”, “Koralowy”, “Sambo”, “Black Beauty”, Tower”, “Golden hybrid”, “Samyl”, “Samyl 1”) two growth stages. The compounds from selected groups, phenolic acids (chlorogenic acid) flavonols (quercetin), were chromatographically determined hydroalcoholic leaf extracts. All tested extracts showed antioxidant effects, but most promising potential: very high content (TPC = 61.85 mg GAE/g), (e.g., DPPH IC50 1.88 mg/mL; CUPRAC IC0.5 0.63 mg/mL) optimal anti-inflammatory (inhibition 41.28%) activities indicated for older “Sampo” variety. Additionally, extract obtained hybrid” variety facilitated treatment wounds scratch test. In summary, best multidirectional pro-health effect treating inflammation specified II (leaves during flowering period); however, wound noted as rich chlorogenic acid younger

Language: Английский

Citations

4
Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation DOI Creative Commons

Xinhua Ni,

Xinyu Luo, Xiaoying Jiang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788

Published: Feb. 8, 2025

Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.

Language: Английский

Citations

0
Antiaging Potential of Lipophilic Extracts of Caulerpa prolifera DOI Creative Commons
Gonçalo P. Rosa, Maria do Carmo Barreto, Ana M. L. Seca

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 83 - 83

Published: Feb. 14, 2025

The cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number products now incorporate extracts or isolated from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity further research. Among these, Caulerpa prolifera (Forsskål) J.V. Lamouroux emerged promising candidate This study provides the most comprehensive phytochemical assessment C. date, revealing source and compounds. analysis identified key components lipophilic profile, predominantly saturated unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate-an endocrine disruptor potentially biosynthesized bioaccumulated by algae. While crude extract exhibited moderate tyrosinase inhibitory activity, overall antioxidant capacity was limited. Fractionation extract, however, yielded subfractions with distinct bioactivities linked changes in chemical composition. Notably, enhanced activities against elastase collagenase were observed enriched 1-octadecanol only traces phthalate. Conversely, activity diminished loss specific such β-sitosterol, erucic acid, nervonic lignoceric acid. work advances understanding relationship between composition bioactivities, emphasizing ingredients, leading more valorization this macroalga.

Language: Английский

Citations

0