The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(13), P. 9551 - 9556
Published: June 18, 2024
Because
of
endogenous
signaling
roles
carbon
monoxide
(CO)
and
its
demonstrated
pharmacological
effects,
there
has
been
extensive
interests
in
developing
fluorescent
CO
probes.
Palladium-mediated
insertion
successfully
used
for
such
applications.
However,
recent
years
have
seen
many
publications
using
uncatalyzed
into
a
hydrazone
double
bond
as
way
to
sense
CO.
Such
chemistry
no
precedents
otherwise.
Further,
the
rigor
CO-sensing
work
was
largely
based
on
ruthenium–carbonyl
complexes
CORM-3
surrogates,
which
reported
chemical
reactivity
release
CO2
instead
unless
presence
strong
nucleophile
dithionite.
For
all
these,
it
is
important
reassess
feasibility
CO-insertion
reaction.
By
studying
two
"CO
probes"
gas,
this
study
finds
evidence
bond.
reaction
between
gas
series
eight
compounds
conducted,
leading
same
conclusion.
findings
are
consistent
with
state-of-the-art
knowledge
carbonylation
do
not
support
mechanism
Medicinal Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
ABSTRACT
Carbon
monoxide
(CO)
is
an
endogenous
signaling
molecule.
It
produced
via
heme
degradation
by
oxygenase
(HMOX),
releasing
stoichiometric
amounts
of
CO,
iron,
and
biliverdin
(then
bilirubin).
The
HMOX‐CO
axis
has
long
been
shown
to
offer
beneficial
effects
modulating
inflammation,
proliferation
cell
death
as
they
relate
tissue
organ
protection.
Recent
years
have
seen
a
large
number
studies
examining
CO
pharmacology,
its
molecular
targets,
cellular
mechanisms
action,
pharmacokinetics,
detection
methods
using
various
delivery
modalities
including
inhaled
gas,
solutions,
types
donors.
Unfortunately,
one
widely
used
donor
type
includes
four
commercially
available
carbonyl
complexes
with
metal
or
borane,
CORM‐2
(Ru
2+
),
CORM‐3
CORM‐A1
(BH
3
CORM‐401
(Mn
+
which
minimal
and/or
unpredictable
production
extensive
CO‐independent
chemical
reactivity
biological
activity.
As
result,
not
all
“CO
activities”
in
the
literature
can
be
attributed
CO.
In
this
review,
we
summarize
key
findings
based
on
gas
solution
for
certainty
active
principal
avoid
data
contamination
resulting
from
confirmed
potential
reactivities
activities
“carrier”
portion
CORMs.
Along
similar
line,
discuss
interesting
research
areas
brain
newly
proposed
CO/HMOX/dopamine
role
cognitive
stimulation
circadian
rhythm.
This
review
critical
future
development
field
steering
clear
complications
caused
chemically
reactive
molecules.
Physiological Reports,
Journal Year:
2024,
Volume and Issue:
12(6)
Published: March 1, 2024
Abstract
Patients
undergoing
cardiopulmonary
bypass
procedures
require
inotropic
support
to
improve
hemodynamic
function
and
cardiac
output.
Current
inotropes
such
as
dobutamine,
can
promote
arrhythmias,
prompting
a
demand
for
improved
with
little
effect
on
intracellular
Ca
2+
flux.
Low‐dose
carbon
monoxide
(CO)
induces
effects
in
perfused
hearts.
Using
the
CO‐releasing
pro‐drug,
oCOm‐21,
we
investigated
if
this
results
from
an
increase
myofilament
sensitivity.
Male
Sprague
Dawley
rat
left
ventricular
cardiomyocytes
were
permeabilized,
force
was
measured
of
‐log
[Ca
]
(pCa)
range
9.0–4.5
under
five
conditions:
vehicle,
oCOm‐21
control
BP‐21,
levosimendan,
(9
cells/group).
sensitivity
assessed
by
concentration
at
which
50%
maximal
is
produced
(pCa
50
).
but
not
BP‐21
significantly
increased
pCa
compared
respectively
5.52
vs.
5.47
5.44;
p
<
0.05).
No
change
phosphorylation
seen
after
treatment.
Pretreatment
heme
scavenger
hemopexin,
abolished
sensitizing
oCOm‐21.
These
hypothesis
that
oCOm‐21‐derived
CO
increases
through
heme‐dependent
mechanism
phosphorylation.
Further
analyses
will
confirm
occurs
intact
heart.
Journal of Photochemistry and Photobiology A Chemistry,
Journal Year:
2024,
Volume and Issue:
453, P. 115600 - 115600
Published: March 19, 2024
Antibiotic-resistant
bacteria
represent
a
growing
threat
to
global
health
and
efforts
continue
be
made
seek
new
ways
of
addressing
this
issue.
Photoactivatable
carbon
monoxide
(CO)-releasing
molecules
(photoCORMs)
could
an
alternative
solution
conventional
antibiotics,
but
their
mechanism
action
is
complex
still
badly
known.
In
the
present
work,
tricarbonylrhenium(I)
(Re-Phe(TPP))
was
developed,
as
well
more
hydrophobic
analogue
substituted
by
adamantyl
moiety
(Re-Ada(TPP)).
When
irradiated
in
near
UV,
these
generate
rapidly
one
molecule
CO,
small
amounts
singlet
oxygen
(1O2).
Their
decarbonylated
photoproducts
D-Re-Phe(TPP)
D-Re-Ada(TPP)
only
1O2,
on
prolonged
period
time.
Finally,
complexes
were
immobilized
biocompatible
cellulose
nanocrystal
(CNC)
matrix,
so
that
diffusive
species
(CO
1O2)
may
active
ones.
The
bactericidal
activity
all
systems
evaluated
two
strains,
causative
main
wound
infections.
No
compound
Pseudomonas
aeruginosa.
contrast,
free
Re-Phe(TPP)
appeared
very
good
antibacterial
agent
dark
Staphylococcus
aureus.
same
adsorbed
CNC
material
ineffective.
Consequently,
its
mainly
attributed
direct
biological
effect.
derivative
Re-Ada(TPP)
presence
light,
while
photoproduct
showed
moderate
activity,
suggesting
production
1O2
not
enough
induce
significant
This
work
allows
identify
limits
Re(I)
photoCORMs
corresponding
nanomaterials,
which
are
little
used
fight
against
bacteria,
it
provides
indications
how
improve
design.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9247 - 9247
Published: Aug. 26, 2024
Myocardial
ischaemia
reperfusion
injury
(IRI)
occurring
from
acute
coronary
artery
disease
or
cardiac
surgical
interventions
such
as
bypass
surgery
can
result
in
myocardial
dysfunction,
presenting
as,
“stunning”,
arrhythmias,
infarction,
and
adverse
remodelling,
may
lead
to
both
a
systemic
localised
inflammatory
response.
This
response
is
regulated
through
the
nucleotide-binding
oligomerisation
domain
(NACHT),
leucine-rich
repeat
(LRR)-containing
protein
family
pyrin
(PYD)-3
(NLRP3)
inflammasome,
multimeric
structure
whose
components
are
present
within
cardiomyocytes
fibroblasts.
The
NLRP3
inflammasome
activated
via
numerous
danger
signals
produced
by
IRI
central
resultant
innate
immune
Inhibition
of
this
inherent
has
been
shown
protect
myocardium
stop
occurrence
syndrome
following
re-establishment
circulation.
Therapies
prevent
formation
clinic
currently
lacking,
therefore,
new
pharmacotherapies
required.
review
will
highlight
role
during
examine
therapeutic
value
inhibition
with
particular
attention
carbon
monoxide,
nitric
oxide,
hydrogen
sulphide
potential
pharmacological
inhibitors
activation.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Carbon
monoxide
(CO),
along
with
nitric
oxide
and
hydrogen
sulfide,
is
one
of
a
trinity
known
gasotransmitters,
or
endogenously
produced
gaseous
molecules
that
signal
regulate
panoply
physiological
functions.
CO
releasing
(CORMs)
are
chemical
tools
enable
the
study
application
this
ephemeral
gas,
that,
ideally,
release
on-demand
when
externally
stimulated.
Surveying
available
triggers,
photolysis
potentially
advantageous:
It
contactless
grants
practitioners
unparalleled
spatial
temporal
control.
However,
current
phototriggered
CORMs
capricious
do
not
meet
needs.
Presented
here
highly
efficient
platform
for
visible
light
triggered
gas.
This
built
on
unique
containing
functionality,
cyclopropenone,
which
undergoes
facile
decarbonylation
through
(470
nm)
mediated
photoredox
catalysis.
Due
to
exothermic
strain-release
occurs
upon
formation
CO,
photoreaction
rapid,
quantitative,
has
tunable
rates.
To
render
photo-CORM
water-soluble,
deliverable,
keep
reactants
in
proximity,
necessary
components
were
polymerized
into
block
copolymers
self-assemble
micelles
(CORMIs).
was
compared
directly
other
state-of-the-art
CORMs,
showing
significantly
improved
production
efficiency,
lower
toxicity,
rates,
consistent
efficacy
