Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: May 6, 2024

Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.

Language: Английский

---

Exploration of Agrocybe aegerita mushroom polysaccharide-polyphenolic complex: Functional properties, binding efficiency, and biological activities

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139309 - 139309

Published: Jan. 1, 2025

Language: Английский

---

Polyphenols as Potential Geroprotectors

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 40(7-9), P. 564 - 593

Published: Jan. 22, 2024

Significance: Currently, a large amount of evidence beneficial effects diets enriched with polyphenols on various aspects health has been accumulated. These phytochemicals have geroprotective potential slowing down the pathological processes associated aging and ensuring longevity. In this study, comprehensive analysis was conducted to determine adherence individual geroprotector criteria. Data from experimental models, clinical trials, epidemiological studies were analyzed. Recent Advances: Sixty-two described increase life span improve biomarkers in animal models. They act via evolutionarily conserved molecular mechanisms, including hormesis maintenance redox homeostasis, epigenetic regulation, response cellular damage, metabolic control, anti-inflammatory senolytic activity. Epidemiological suggest that certain for prevention treatment diseases, cancer, disorders, cardiovascular conditions humans. Critical Issues: Among reviewed phytochemicals, chlorogenic acid, quercetin, epicatechin, genistein, resveratrol, curcumin identified as compounds highest potential. However, there is lack unambiguous information effectiveness safety increasing span, preventing treating aging-associated diseases Future Directions: Further research needed fully understand considering their long-term consumption, modification bioavailability, complex interactions between different groups other well individuals status. Antioxid. Redox Signal. 40, 564–593. Color images are available online.

Language: Английский

---

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5

Published: March 28, 2024

MicroRNAs (miRNAs) are short RNA molecules that not involved in coding for proteins. They have a significant function regulating gene expression after the process of transcription. Their participation several biological processes has rendered them appealing subjects investigating age-related disorders. Increasing data indicates miRNAs can be influenced by dietary variables, such as macronutrients, micronutrients, trace minerals, and nutraceuticals. This review examines influence factors nutraceuticals on regulation miRNA relation to aging. We examine present comprehension disruption illnesses emphasize possibility manipulation means prevention or treatment. Consolidating animal human research is essential validate significance control living organisms, despite abundance information already provided studies. elucidates complex interaction among miRNAs, nutrition, aging, offering valuable insights into promising areas further potential therapies

Language: Английский

---

Influence of Mediterranean Diet and Incidence of Global Warming on Food Habits and Plant Growth in Northern Mediterranean Latitudes: Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 677 - 677

Published: Feb. 14, 2025

Climate change has consequences for farming, food diversity and availability, diet habits. There is now evidence that the Mediterranean climate rapidly spreading to Northern European latitudes. This narrative review aims identify relevant studies related could favor progression of in northern latitudes Europe, mainly France, predict what these changes on human be, especially using concept diet, with subsequent impacts health, eating was realized by consulting PubMed, Scopus, Science Direct, Google Scholar databases. The key points developed this are as follows: investigating a healthy supporting health benefits perspectives; similarities other places world at same latitudes; resulting plant growth, habits; perspectives need societal adaptations populations towards agriculture, food, cooking changes. As facilitates development new farming practices more or fewer environmental impacts, growth plants highest such olive trees, pomegranates, almonds, already begun economic reasons. In near future, besides interests, will consumption several products associated context, producers consumers play major roles.

Language: Английский

---

Cold plasma enhances antioxidant, anticancer, and functional properties of Xinong Black Spike flour through modulation of starch and phenolic macromolecules

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142803 - 142803

Published: April 1, 2025

Language: Английский

---

Oxysterols, age-related-diseases and nutritherapy: focus on 7-ketocholesterol and 7β-hydroxycholesterol

Prostaglandins & Other Lipid Mediators, Journal Year: 2025, Volume and Issue: unknown, P. 106993 - 106993

Published: April 1, 2025

Language: Английский

---

Unveiling the Anti-Aging Potential of Marine Natural Bioproducts

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 165 - 165

Published: April 11, 2025

Aging is a natural process resulting in the progressive impairment of multiple functions human body, leading to decline cellular functionality and development aging-related diseases. External stress factors, such as ultraviolet (UV) radiation, pollution, toxin exposure, increase oxidative stress, damage repair mechanisms, speed up aging processes. With rise world’s population, there are enlarged demands for use sustainable products food, nutrient supplements cosmetics that can slow down prolong healthy life longevity. Algae, including both macroalgae microalgae, have been recognised source valuable proteins, amino acids, fatty vitamins, minerals useful consumption medical applications. increasing nutraceutical pharmaceutical bioproducts from environmentally friendly resources, biotechnological industry, over recent decades, has had provide new, advanced solutions using modern high-throughput omics technologies. The application proteomics area discoveries with anti-aging properties become more popular wide industry New profiling provides better understanding changes occurring protein peptide content, their structure, function interactions, well regulatory processes molecular pathways. Mass spectrometry-based used range applications identification, characterisation, quantification proteins within proteome sub-proteome. chemical facilitated identification approach included synthesis probes target fishing, allowing interest. This review focuses on marine macro- microalgal compounds novel approaches, providing experimental evidence involvement should facilitate innovative approaches

Language: Английский

---

Ferulic acid: extraction, estimation, bioactivity and applications for human health and food

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Ferulic acid (( E )‐3‐(4‐hydroxy‐3‐methoxy‐phenyl) prop‐2‐enoic acid) is a derivative of caffeic found in most plants. This abundant phenolic compound exhibits significant antioxidant capacity and broad spectrum therapeutic effects, including anti‐inflammatory, antimicrobial, anticancer, antidiabetic, cardiovascular neuroprotective activities. It absorbed more quickly by the body stays bloodstream for longer period compared with other acids. widely used food (namely whole grains, fruits, vegetables coffee), pharmaceutical cosmetics industries. The current review highlights ferulic its pharmacological activities, reported mechanisms action, applications (food preservative, additive, processing, supplements packaging form edible films) role human health. In future, demand industries will increase. © 2024 Author(s). Journal Science Food Agriculture published John Wiley & Sons Ltd on behalf Society Chemical Industry.

Language: Английский

---

The Effect of Maturity Stage on Polyphenolic Composition, Antioxidant and Anti-Tyrosinase Activities of Ficus rubiginosa Desf. ex Vent. Extracts

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1129 - 1129

Published: Sept. 18, 2024

spp. are often used as food and in traditional medicine, their biological activities anti-inflammatory diuretic, for wound healing, antimicrobial agents have been largely reviewed. The aim of this work was to investigate the polyphenol content antioxidant anti-tyrosinase properties extracts from

Language: Английский

---