Delta Variant in the COVID-19 Pandemic: A Comparative Study on Clinical Outcomes Based on Vaccination Status

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(4), P. 358 - 358

Published: March 28, 2024

Background: As the global battle against COVID-19 pandemic endures, spread of Delta variant has introduced nuanced challenges, prompting a examination. Materials and Methods: We performed multilevel logistic regression analysis encompassing 197 patients, comprising 44 vaccinated individuals (V group) 153 unvaccinated counterparts (UV). These afflicted with SARS-CoV-2, were hospitalized between October 2021 February 2022 at department University Centre in Cluj-Napoca, Romania. compared patient characteristics, CT lung involvement, Padua score, oxygen saturation (O2 saturation), ventilation requirements, dynamics arterial blood gas (ABG) parameters, ICU admission rates, mortality rates two groups. Results: The UV group exhibited statistically significant (p < 0.05) proclivity toward developing more severe form infection, marked by elevated requirement, admission, mortality. Conclusion: Our findings underscore substantial efficacy vaccine diminishing incidence disease, lowering admissions, mitigating among patients.

Language: Английский

---

Glycemic Dysregulation, Inflammation and Disease Outcomes in Patients Hospitalized with COVID-19: Beyond Diabetes and Obesity

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1468 - 1468

Published: June 28, 2023

Introduction: During the COVID-19 pandemic, diabetes mellitus (DM) and obesity were associated with high rates of morbidity mortality. The aim this study was to investigate relationship between markers inflammation, disease severity, insulin resistance, hyperglycemia, outcomes in patients without obesity. Materials Methods: Epidemiological, clinical, laboratory data collected from University Hospital Ioannina Registry included hospitalized March 2020 December 2022. cohort divided into three subgroups based on presence DM, obesity, or absence both. Results: In diabetic patients, elevated CRP, IL-6, TRG/HDL-C ratio, TyG index, severe pneumonia, hyperglycemia extended hospitalization. Increased NLR, decreased PFR a higher risk death. obese subgroup, lower levels longer hospitalization death, while lung DM resistance indices, during Conclusion: Inflammatory severity indices strongly across all subgroups.

Language: Английский

---

The Association between Dyslipidemia and Pulmonary Diseases

Journal of Atherosclerosis and Thrombosis, Journal Year: 2024, Volume and Issue: 31(9), P. 1249 - 1259

Published: July 11, 2024

Dyslipidemia is one of the most common diseases worldwide. As a component metabolic syndrome, prevalence and mechanism by which dyslipidemia promotes cardiovascular has been well studied, although relationship between pulmonary not understood. Because lung respiratory organ with large surface area exposed to environment outside body, it continuously inhales various substances. result, have vast diversity, including chronic inflammatory diseases, allergic cancers, infectious diseases. Recently, growing evidence suggested that plays role in pathogenesis prognosis We herein review current understanding obstructive asthma, cancer, community-acquired pneumonia, tuberculosis, nontuberculous mycobacterial disease, COVID-19. In addition, we focus on recent utility statins, specifically 3-hydroxy-3-methylglutaryl-coA reductase inhibitors, prevention treatment described above.

Language: Английский

---

GrimAge is elevated in older adults with mild COVID-19 an exploratory analysis

GeroScience, Journal Year: 2024, Volume and Issue: 46(4), P. 3511 - 3524

Published: Feb. 15, 2024

Language: Английский

---

Heterogeneity of the effect of the COVID-19 pandemic on the incidence of Metabolic Syndrome onset at a Japanese campus

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17013 - e17013

Published: April 5, 2024

Background The coronavirus disease 2019 (COVID-19) outbreak began in China December 2019, with the World Health Organization declaring a state of emergency January 2020. Worldwide implementation lockdown measures to slow spread virus led reduced physical activity, disrupted eating habits, mental health issues, and sleep disturbances, which increased risk lifestyle-related diseases such as metabolic syndrome (MetS). During COVID-19 pandemic, healthcare workers, especially intensive care experienced longer working hours burnout, further diseases. Accordingly, it is important identify individuals at new-onset MetS during could direct preventive interventions. This study aimed assess heterogeneous impact pandemic on incidence based conditional average treatment effect (CATE) at-risk populations. Methods analyzed checkup data obtained from Okayama University Shikata Campus workers using paired baseline follow-up years. Baseline encompassed 2017 respective 2018 Furthermore, Japan 2020, who underwent checkups 2020 were considered “unexposed” “exposed,” respectively. As campus has several departments, comparisons among departments made. primary outcome was follow-up. Predictor variables included results, sex, age, department (administrative, research, medical, or department). X-learner used calculate CATE. Results 3,572 eligible (unexposed, n = 2,181; exposed, 1,391). Among them, 1,544 (70.8%) 866 (62.3%) participants unexposed exposed groups, respectively, females. mean age (±standard deviation) groups 48.2 ± 8.2 47.8 8.3 years, probability by 4.4% overall population. According department, showed highest CATE, 15.4% increase. Moreover, there large heterogeneity according department. high-CATE group characterized older urinary protein, elevated liver enzymes, higher triglyceride levels, history hyperlipidemia treatment. Conclusions demonstrated that MetS, this showing single Japanese campus. Regarding specific populations, an MetS. At-risk populations require interventions case current persists new occurs.

Language: Английский

---

Developing A Baseline Metabolomic Signature Associated with COVID-19 Severity: Insights from Prospective Trials Encompassing 13 U.S. Centers

Metabolites, Journal Year: 2023, Volume and Issue: 13(11), P. 1107 - 1107

Published: Oct. 24, 2023

Metabolic disease is a significant risk factor for severe COVID-19 infection, but the contributing pathways are not yet fully elucidated. Using data from two randomized controlled trials across 13 U.S. academic centers, our goal was to characterize metabolic features that predict and define novel baseline metabolomic signature. Individuals (n = 133) were dichotomized as having mild or moderate/severe based on WHO ordinal scale. Blood samples analyzed using Biocrates platform, providing 630 targeted metabolites analysis. Resampling techniques machine learning models used determine associated with disease. Ingenuity Pathway Analysis (IPA) functional enrichment To aid in clinical decision making, we created metabolomics signatures of low-correlated molecules. Multivariable logistic regression fit associate these training data. A three-metabolite signature, lysophosphatidylcholine C17:0, dihydroceramide (d18:0/24:1), triacylglyceride (20:4_36:4), resulted best discrimination performance an average test AUROC 0.978 F1 score 0.942. Pathways related amino acids significantly enriched IPA analyses, mitogen-activated protein kinase 5 (MAP2K5) differentially activated between groups. In conclusion, lipid metabolism efficiently discriminated vs. SDMA GABA demonstrated potential discriminate groups well. The regulator groups, suggesting further investigation therapeutic pathway.

Language: Английский

---

INFLUENCE OF COMORBIDITIES ON THE SEVERITY OF COVID-19

University therapeutic journal, Journal Year: 2024, Volume and Issue: 6(1), P. 26 - 48

Published: June 17, 2024

Уже в начале пандемии было замечено влияние сопутствующих заболеваний на степень тяжести и исходы COVID-19. С тех пор большое внимание сосредоточено проблемах коморбидности, связанных с инфекцией SARS-CoV-2, долгосрочными последствиями Хронические заболевания, которые нарушают гомеостаз организма, делают пациентов более склонными к инфекциям. Наличие хронических ассоциировано высокой степенью COVID-19 высоким риском смерти от данной инфекции. Помимо респираторных осложнений, новая коронавирусная инфекция связана повышенным сердечно-сосудистых событий, таких как сердечные приступы, инфаркты, инсульты тромбозы. Пациенты ранее существовавшими артериальной гипертензией, сердечно-сосудистыми заболеваниями, диабетом ожирением особенно восприимчивы этим осложнениям. У пациентов, инфицированных вирусом наиболее распространенными сопутствующими хроническими влияющими развитие прогноз, являются метаболические расстройства, такие метаболический синдром, ожирение, гиперлипидемия диабет, а также сердечно-сосудистые заболевания артериальная гипертензия. Патофизиологические механизмы метаболических имеют своей основе много общего коронавирусной инфекцией. Вирус SARSCoV2 способен напрямую повреждать сердце сосудистый эндотелий вызывать системную воспалительную реакцию протромботическое состояние, усугубляют сопутствующие заболевания. многих пожилого возраста, имеются анамнезе два или Определение индивидуального вклада коморбидных факторов прогрессирования тяжелые формы важно, так предотвращение осложнений неблагоприятных событий зависит лежащих их механизмов влияния течение В этом обзоре мы представляем существующую информацию о влиянии основных Early in the pandemic, impact of comorbidities on severity and outcomes was noted. Since then, much attention has focused comorbidity issues associatedwith SARS-CoV-2 infection long-term consequences Chronic diseases that disrupt body’s homeostasis make patients more prone to infections. Having chronic isassociated with higher a risk death from In addition respiratory complications, is associated an increased cardiovascularevents such as heart attacks, myocardial infarctions, strokes thrombosis. Patients pre-existing hypertension, cardiovascular disease, diabetes, obesity are particularly susceptible these complications. The most common comorbid infected SARSCoV- 2 coronavirus affect development prognosis metabolic disorders syndrome, obesity, hyperlipidemia well hypertension diseases. pathophysiological mechanisms have infection. virus capable directly damaging vascular endothelium inducing systemic inflammatory response prothrombotic state aggravate Many patients, especially older history two or identifying individual contribution factors progression severe forms important, since prevention complications adverse events depends underlying influence course this review, we present existing information major

Language: Русский

---

Mortality Impact of Severe COVID-19 in the ICU: A Study from the Târgu Mureș Support Unit

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1232 - 1232

Published: Sept. 26, 2024

(1) Background: Since the onset of COVID-19 pandemic, it has been recognized that a considerable proportion critically ill patients may die this disease. The current study aims to assess overall 1-year outcomes within UMFST Unit, providing valuable insights into efficacy specialized care facilities in managing severe cases COVID-19. (2) Methods: This is retrospective monocentric observational including 294 confirmed have SARS-CoV-2 infection. Demographic data and clinical paraclinical parameters were assessed. Survival probabilities estimated using Kaplan-Meier curves. (3) Results: Overall, mortality was 89.4%. All deaths occurred in-hospital, with two dying after 28 days. Diabetes mellitus, chronic kidney failure, cerebrovascular disease, atrial fibrillation more prevalent deceased patients. Thirty percent needed endotracheal intubation during first 24 h. incidence hospital-acquired pneumonia higher among SOFA score significantly different between vs. survivors. survival analysis showed use noradrenaline increased likelihood surviving (4) Conclusions: comorbidities primary factors contributing rate unit.

Language: Английский

---

Associação entre síndrome metabólica e COVID-19

Revista Eletrônica Acervo Saúde, Journal Year: 2024, Volume and Issue: 24(11), P. e17128 - e17128

Published: Nov. 30, 2024

Objetivo: Analisar os mecanismos fisiopatológicos da associação entre a COVID-19 e síndrome metabólica (SM). Revisão bibliográfica: Apesar evidência de alto risco resultados adversos em pessoas com metabólica, pouco se sabe sobre as diferenças na eficácia segurança sem metabólica. A relação traz questões fisiológicas que tornam suscetível à infecção, bem como complicações durante após devido baixa resposta imunológica causada pela inflamação crônica. presença comorbidades necessidade prevenção, indivíduos SM infectados não são corretamente orientados profilaxia atual seus benefícios diante do quadro infeccioso. Considerações finais: O conhecimento evidências epidemiológicas COVID-19, inter-relações patogênicas, considerações manejo para sequelas pós-COVID, sua é sustentado ter um maior cuidado vivem SM.

---