Thyroid dysfunction in COVID-19

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(6), P. 336 - 348

Published: Feb. 12, 2024

Language: Английский

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The Growing Understanding of the Pituitary Implication in the Pathogenesis of Long COVID-19 Syndrome: A Narrative Review

Advances in respiratory medicine, Journal Year: 2024, Volume and Issue: 92(1), P. 96 - 109

Published: Feb. 14, 2024

Long COVID-19, also known as post-acute sequelae of SARS-CoV-2 infection, is a condition where individuals who have recovered from the acute phase COVID-19 continue to experience range symptoms for weeks or even months afterward. While it was initially thought primarily affect respiratory system, has become clear that can involve various organs and systems, including endocrine which includes pituitary gland. In context there growing understanding potential implications The virus directly gland, leading abnormalities in hormone production regulation. This result such fatigue, changes appetite, mood disturbances. persistent often debilitating following may be explained by deficiencies ACTH Growth Corticotropin insufficiency dysregulation body’s stress response lead prolonged feelings stress, disturbances patients. Simultaneously, somatotropin growth, muscle function, energy metabolism, potentially causing weakness, exercise intolerance, body composition. Recently, some authors suggested involvement gland Post Syndrome. exact mechanisms viral action on infected cells remain under discussion, but inflammatory autoimmune are implicated. aim our study will review main complications infection. Moreover, we explain possible persistence

Language: Английский

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Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology

Medical Review, Journal Year: 2024, Volume and Issue: 5(1), P. 66 - 75

Published: July 1, 2024

Long COVID, as currently defined by the World Health Organization (WHO) and other authorities, is a symptomatic condition that has been shown to affect an estimated 10 %-30 % of non-hospitalized patients after one infection. However, COVID-19 can also cause organ damage in individuals without symptoms, who would not fall under current definition COVID. This damage, whether or not, lead various health impacts such heart attacks strokes. Given these observations, it necessary either expand COVID include recognize COVID-19-induced distinct affecting many asymptomatic infections. It important consider known adverse outcomes, including conditions cancers, be until harm thresholds are reached. Many more medical identified testing than those recognized through reported symptoms. therefore similarly while symptoms associated with there have displaying this characterization monitoring

Language: Английский

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Clinical Spectrum of Long COVID: Effects on Female Reproductive Health

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1142 - 1142

Published: July 16, 2024

The COVID-19 pandemic caused by SARS-CoV-2 has presented numerous health challenges, including long-term COVID, which affects female reproductive health. This review consolidates the current research on impact of menstrual cycle, ovarian function, fertility, and overall gynecological study emphasizes role angiotensin-converting enzyme receptors in viral entry subsequent tissue-specific pathological effects. It also explores potential influence long COVID hormonal balance immune responses, contributing to irregularities impaired function. findings indicate a higher prevalence among women, highlighting substantial implications for need sex-sensitive longitudinal studies. Enhanced surveillance targeted are essential develop effective interventions that prioritize women's well-being following infection. advocates sex-informed approach ongoing healthcare strategies, aiming provide up-to-date pertinent data providers general public, ultimately improving outcomes females affected COVID.

Language: Английский

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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

Language: Английский

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Differentially‐regulated miRNAs in COVID‐19: A systematic review

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 33(4)

Published: May 5, 2023

Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is responsible for coronavirus disease of 2019 (COVID‐19) that infected more than 760 million people worldwide with over 6.8 deaths to date. COVID‐19 one the most challenging diseases our times due nature its spread, effect on multiple organs, and an inability predict prognosis, ranging from being completely asymptomatic death. Upon infection, SARS‐CoV‐2 alters host immune response by changing host‐transcriptional machinery. MicroRNAs (miRNAs) are regarded as post‐transcriptional regulators gene expression can be perturbed invading viruses. Several in vitro vivo studies have reported such dysregulation miRNA upon infection. Some this could occur anti‐viral viral Viruses themselves counteract mounting their own pro‐viral facilitates virus aspect which may cause pathogenesis. Thus, miRNAs serve possible biomarkers people. In current review, we summarised analysed existing data about patients determine concordance between studies, identified those potential during progression, death, even other co‐morbidities. Having vital not only predicting but also development novel miRNA‐based anti‐virals therapeutics become invaluable case emergence new variants pandemic future.

Language: Английский

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Possibility of intrauterine transmission from mother to fetus/newborn: Systematic review and meta-analysis of diagnostic methods to detect SARS-CoV-2 infection

European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2024, Volume and Issue: 295, P. 181 - 200

Published: Feb. 13, 2024

Language: Английский

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Absence of Type I Interferon Autoantibodies or Significant Interferon Signature Alterations in Adults With Post–COVID-19 Syndrome

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 11(1)

Published: Dec. 19, 2023

Abstract Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such were proposed affect post–COVID-19 syndrome (PCS), possibly causing persistent fatigue for >12 weeks after confirmed SARS-CoV-2 infection. In current study, we investigated 128 patients with PCS, 21 survivors of COVID-19, and 38 individuals who asymptomatic. We checked IFN-α, IFN-β, IFN-ω. Few PCS had but no activity, indicating a limited role pathogenesis. subset consisting 28 evaluated IFN-stimulated gene activity showed that it did not correlate fatigue. conclusion, impairment IFN is unlikely responsible adult PCS.

Language: Английский

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SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation?

Published: Feb. 10, 2024

VitD deficiency-risk factor pathologyHans-Klaus Goischke (2024) SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation?rate was significantly lower than with values below or deficiency [17].Current data suggest protective role for VitD, particularly risk of intensive care unit admission reduced death [18,19].In addition, the occurrence Long-Covid is an aspect implementing this simple, effective, safe costeffective therapy broad therapeutic window prevention treatment .Although there still no indisputable evidence that Vit supplementation (VitD suppl.)reduces SARSCov-2 infection healthy individuals, collective it benefits vulnerable individuals [23].PwMS comorbidities, psychiatric illnesses, hypertension, obesity (an increased BMI may correlate severe course Covid-19), age > 50 years, disability methylprednisolone boost as well some DMTs (disease-modifying therapies) have higher COVID-19 courses [24-26].Infections (SARS-COV-2) can increase MS symptoms (pseudo-relapses) cause real relapses [27].In post-COVID syndrome (Long Covid), one eight patients presents such fatigue, shortness breath, cough, joint pain, chest muscle headache paresthesia limbs after at least 3 months.The latter also occur PwMS per se [28,29].If vitamin administration results infection, severity illness to people risk, occurs less frequently [18,19,21,22,30-33], not ethically justifiable withhold high dose vitamin-D from risk. Mechanisms Action COVID-19Barrea et al. list detail 14 mechanisms described by suppl. be sufficient Covid 19 vaccination supported [19,29,32,[34][35][36][37][38].Vit its metabolites inactivate viruses (increase antimicrobial peptide cathelicidin, defensins), lead reduction cytokine storm, reduce matrix metalloproteinase-9 concentration thereby host's metabolic tolerance damage, pneumonia myocarditis, pro-inflammatory cytokines, especially interleukin 6 (IL-6), which promotes permeability BBB, leads potentiation CNS damage PwMS, serious [29,[39][40][41][42]. enables neuroprotection reducing inflammation oxidative stress.Low 25(OH)D levels were inversely correlated IL-6 independent predictors mortality [43].1,25(OH)2D3 inhibits immunoglobulin synthesis, regulates B cell activity reduces auto-Ab production.It converts cells into plasma [18].Vit EBV [29].Current studies show chronic Long Covid-19 reactivation latent Epstein-Barr virus (EBV) worsening health status [44-48].In MS, level molecular mimicry between transcription EBNA-1 protein GlialCAM (glial adhesion molecule central nervous system [49].Bernal able detect detecting DNA antibodies against EBV-lytic genes [50].

Language: Английский

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A multimodal approach for treating post-acute infectious syndrome

Brain medicine :, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 7

Published: Aug. 30, 2024

Long-term complications, such as extensive fatigue and cognitive issues, are known from various infections, including SARS-CoV-2, influenza virus, or Borrelia burgdorferi . The pathology is mostly unknown differs between patients. Unfortunately, there currently no common effective treatment. In this perspective, we imply that post-acute infectious syndromes due to a variety of factors, among others diminished tissue perfusion, infiltration by viruses, inflammation, oxidative stress, not one specific biomarker can be used measure these syndromes. Thus, suggest score based on number criteria/factors should assess Consequently, probably single treatment treat group patients, multimodal regimen comprising combination pharmacotherapy, metformin naltrexone with anti-inflammatory effects, alongside physical therapies extracorporeal apheresis transcutaneous neurotherapy. This combined approach aims reduce levels enhance functions. implies reset the systems achieved for

Language: Английский

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