A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis DOI Creative Commons

Hannaneh Azimizonuzi,

Arman Ghayourvahdat,

Mareb Hamed Ahmed

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

Theranostics is a way of treating illness that blends medicine with testing. Specific characteristics should be present in the best theranostic agents for cancer: (1) drugs safe and non-toxic; (2) they able to treat cancer selectively; (3) build up only cancerous tissue. Liposomes (LPs) are one most efficient drug delivery methods based on nanotechnology. Stealth LPs commercial have recently had an impact treatment. Using valuable information from each imaging technique, along multimodality functionality liposomal therapeutic agents, makes them very appealing personalized monitoring how well working against vivo predicting therapies will work. On other hand, their use as nanoparticle systems currently research development phase. Nanoscale system innovation has made LP-nanoparticle hybrid structures useful combining methods. LP-hybrid nanoparticles better at killing cells than LP counterparts, making excellent options vitro applications. Hybrid liposomes (HLs) could used future carriers find targets. This would combine features synthetic biological systems. Overarchingly, this article provided comprehensive overview many types detection, therapy, analysis. An evaluation pros cons HLs detection treatment also been conducted. The study included recent significant We conclude by outlining potential benefits drawbacks approach concurrent different malignancies, its prospects.

Language: Английский

A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis DOI Creative Commons
Yongzhi Cui, Yuanyuan Guo, Li Kong

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 10, P. 207 - 221

Published: Sept. 17, 2021

The complex pathogenesis of osteoporosis includes excessive bone resorption, insufficient formation and inadequate vascularization, a combination which is difficult to completely address with conventional therapies. Engineered exosomes carrying curative molecules show promise as alternative therapies, but depend on specifically-functionalized vesicles appropriate engineering strategies. Here, we developed an exosome delivery system based secreted by mesenchymal stem cells (MSCs) derived from human induced pluripotent (iPSCs). engineered BT-Exo-siShn3, took advantage the intrinsic anti-osteoporosis function these special MSC-derived collaborated loaded siRNA Shn3 gene enhance therapeutic effects. Modification bone-targeting peptide endowed BT-Exo-siShn3 ability deliver osteoblasts specifically. Silencing osteoblastic enhanced osteogenic differentiation, decreased autologous RANKL expression thereby inhibited osteoclast formation. Furthermore, silencing increased production SLIT3 consequently facilitated especially type H vessels. Our study demonstrated that could serve promising therapy kill three birds one stone implement comprehensive

Language: Английский

Citations

155
Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives DOI Creative Commons
Han Liu, Qin Zhang, Sicheng Wang

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 14, P. 169 - 181

Published: Dec. 17, 2021

Nanosized extracellular vesicles derived from bacteria contain diverse cargo and transfer intercellular bioactive molecules to cells. Due their favorable interactions, cell membrane-derived bacterial (BEVs) have great potential become novel drug delivery platforms. In this review, we summarize the biogenesis mechanism compositions of various BEVs. addition, an overview effective isolation purification techniques BEVs is provided. particular, focus on application as nanocarriers for delivery. Finally, advances challenges after providing a comprehensive discussion in each section. We believe that deeper understanding will open new avenues exploitation applications.

Language: Английский

Citations

152
Bone Repair Biomaterials: A Perspective from Immunomodulation DOI
Yili Wang, Hao Zhang, Yan Hu

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(51)

Published: Oct. 9, 2022

Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus research has transitioned from bioinert bioactive biomaterials. many not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology revealed that immune system, which macrophages are critical components, plays essential regulatory role regeneration. this review, healing explored developments promote regeneration by modulating macrophage polarization improving osteoimmune microenvironment reviewed. This review provides reference development application repair immunomodulation perspective.

Language: Английский

Citations

126
Bone/cartilage targeted hydrogel: Strategies and applications DOI Creative Commons
Hao Zhang,

Shunli Wu,

Weikai Chen

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 156 - 169

Published: Nov. 11, 2022

The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.

Language: Английский

Citations

124
Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases DOI Creative Commons
Jiawei Guo, Fuxiao Wang, Yan Hu

et al.

Cell Reports Medicine, Journal Year: 2023, Volume and Issue: 4(1), P. 100881 - 100881

Published: Jan. 1, 2023

Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium IL-10 knockout induced piroxicam, mass quality are significantly decreased. Colitis mice demonstrate a lower formation rate fewer osteoblasts in femur. Bone marrow mesenchymal stem/stromal cells (BMSCs) from tend to differentiate into adipocytes rather than osteoblasts. Serum patients IBD promotes adipogenesis of human BMSCs. RNA sequencing reveals that downregulates Wnt signaling For treatment, exosomes Golgi glycoprotein 1 inserted could carry agonist accumulate via intravenous administration. They alleviate loss, promote formation, accelerate fracture healing mice. Collectively, BMSC commitment microenvironment contributes quantity be rescued redirecting differentiation toward through bone-targeted drug delivery.

Language: Английский

Citations

124
Silk fibroin-based biomaterials for cartilage/osteochondral repair DOI Creative Commons
Ziyang Zhou,

Jin Cui,

Shunli Wu

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 5103 - 5124

Published: Jan. 1, 2022

Osteoarthritis (OA) is a common joint disease with high disability rate.In addition, OA not only causes great physiological and psychological harm to patients, but also puts pressure on the social healthcare system.Pathologically, disintegration of cartilage lesions subchondral bone are related OA.Currently, tissue engineering, which expected overcome defects existing treatment methods, had lot research in field cartilage/osteochondral repair.Silk fibroin (SF), as natural macromolecular material good biocompatibility, unique mechanical properties, excellent processability degradability, holds potential engineering.Nowadays, SF been prepared into various materials adapt demands repair.SF-based biomaterials can be functionally modified enhance repair performance further.In this review, preparation types, structures, functional modifications SF-based used for summarized discussed.We hope that review will provide reference design development field.

Language: Английский

Citations

120
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression DOI Creative Commons
Hao Zhang, Lipeng Wang, Jin Cui

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(14)

Published: April 5, 2023

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated hypoxia-inducible factor alpha subunit (HIF-1α) chondrocytes led Lcp1 impeded angiogenesis, maintained hypoxia environment joints delayed progression. Stabilization of HIF-1α degeneration, knockdown Hif1a abolished protective effects knockout. Last, we that Oroxylin A, an Lcp1-encoded l-plastin (LPL) inhibitor, could alleviate In conclusion, maintaining hypoxic attractive strategy for treatment.

Language: Английский

Citations

100
M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator DOI Creative Commons
Yili Wang,

Qiushui Lin,

Hao Zhang

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 273 - 283

Published: June 1, 2023

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play key role in the process of healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory anti-inflammatory functions. Therefore, modulation macrophage subtype beneficial for Exosomes perform an important improving osteoimmune microenvironment due their extremely low immunogenicity and high bioactivity. In this study, we extracted M2-exosomes used them intervene bone repair diabetic fractures. The results showed significantly modulate decreasing proportion macrophages, thereby accelerating We further confirmed induced conversion macrophages stimulating PI3K/AKT pathway. Our study offers fresh perspective potential therapeutic approach improve

Language: Английский

Citations

99
Biological Features of Extracellular Vesicles and Challenges DOI Creative Commons
Ye Zeng, Yan Qiu, Wen‐Li Jiang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: June 24, 2022

Extracellular vesicles (EVs) are with a lipid bilayer membrane on the outside, which widely found in various body fluids and contain biological macromolecules such as DNA, RNA, lipids proteins inside. EVs were once thought to be for removal of waste materials, but now known involved variety pathophysiological processes many diseases. This study examines advantage challenges associated their application. A more rational use advantageous properties composition specificity, specific targeting, circulatory stability, active penetration barriers, high efficient drug delivery vehicles anticancer vaccines, oxidative phosphorylation activity enzymatic activity, resolution shortcomings isolation purification methods, storage conditions pharmacokinetics biodistribution patterns during will facilitate clinical application EVs.

Language: Английский

Citations

85
Targeted and responsive biomaterials in osteoarthritis DOI Creative Commons
Jiadong Li,

Hao Zhang,

Yafei Han

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 931 - 954

Published: Jan. 1, 2023

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.

Language: Английский

Citations

72