The wonders of X-PDT: an advance route to cancer theranostics DOI Creative Commons
Asim Mushtaq, M. Zubair Iqbal,

Jianbin Tang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 25, 2024

Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged promising advancement, revolutionizing traditional (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays external stimuli. Recent developments in X-ray have shown trend toward minimizing radiation doses remarkably low levels after proof-of-concept demonstration. Early detection real-time monitoring are crucial aspects treatment. Sophisticated imaging techniques been enhanced introduction luminescence nano-agents, alongside contrast nanomaterials based on attenuation. luminescence-based vivo offers excellent sensitivity superior image quality deep tissues at reasonable cost, due unhindered penetration unimpeded auto-fluorescence X-rays. This review emphasizes significance responsive theranostics, exploring their mechanism action, feasibility, biocompatibility, prospects imaging-guided deep-seated tumors. Additionally, it discusses applications X-PDT treating breast cancer, liver lung skin colorectal cancer.

Language: Английский

Cu-related agents for cancer therapies DOI
Chunhui Wang, Xinda Yang, Chunyan Dong

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 487, P. 215156 - 215156

Published: April 13, 2023

Language: Английский

Citations

33
Light Conversion Nanomaterials for Wireless Phototherapy DOI
Bowen Sun,

Jia Yee Teo,

Jiaxi Wu

et al.

Accounts of Chemical Research, Journal Year: 2023, Volume and Issue: 56(10), P. 1143 - 1155

Published: March 10, 2023

ConspectusPhototherapy including optogenetics, photodynamic therapy (PDT), photothermal (PTT), and photoimmunotherapy (PIT) has been proven to be effective against different diseases. However, as the name suggests, phototherapy requires light irradiation, thus its therapeutic efficiency is often restricted by limited depth of penetration within biological tissue. This limitation significantly adverse PDT optogenetics because both therapies are usually activated with UV visible very poor tissue efficiency. Current delivery methods involve cumbersome setups require optical fiber or catheter insertion, which not only restrict movement patients but also impose incompatibility issues chronic implantation. To address existing challenges, wireless was developed through various approaches over recent years, relies on implantable electronic devices. application devices invasion during implantation, unwanted heat generation, immunogenicity these devices.Over applying conversion nanomaterials transducers for garnered much interest. Compared fiber, can easily injected into body minimal invasiveness surface functionalized increase their biocompatibility cell accumulation Commonly applied include upconversion nanoparticles (UCNPs), X-ray nanoscintillators, persistent luminescence (PLNPs). UCNPs nanoscintillators respectively convert near-infrared (NIR) X-ray, have good efficiency, light, suitable activating phototherapy. PLNPs excited external such X-rays NIR retain long afterglow after removal excitation source. As a result, in potentially reduce irradiation time from sources, minimizing photodamage. Account aims briefly discuss (i) mechanisms phototherapies, (ii) development nanomaterials, (iii) phototherapy, highlighting how they relieve current challenges (iv) perspectives future

Language: Английский

Citations

30
Combination of disulfiram and Copper−Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer DOI Creative Commons
Lijun Yang,

Cancan Yao,

Zhenning Su

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 96 - 111

Published: March 1, 2024

Endometrial cancer (EC) stands as one of the most prevalent gynecological malignancies affecting women, with its incidence and disease-related mortality steadily on rise. Disulfiram (DSF), an FDA-approved medication primarily used for treating alcohol addiction, has exhibited promising anti-tumor properties. Studies have revealed DSF's capacity enhanced activity, particularly when combined copper. The novel Copper-Cysteamine (CuCy) compound, Cu

Language: Английский

Citations

13
Copper-based nanomaterials for biomedical applications DOI Creative Commons
Qichen Wei, Yue Pan, Zheng Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149040 - 149040

Published: Jan. 23, 2024

Among metal-based nanomaterials, Copper-based nanomaterials (Cu-BNMs) have become a research hotspot in the biomedical field due to their good biocompatibility and unique properties. However, there are fewer systematic summaries of copper-based especially synthesis Cu-BNMs. As for applications, Cu-BNMs been widely used fields antimicrobial, imaging, therapeutics, showing excellent promising Herein, this review firstly introduces classification various methods synthesizing through both top-down bottom-up types. Then, applications within three tumor therapy classified summarized. Finally, challenges faced application future development c discussed provide basic information illustrations

Language: Английский

Citations

9
Nano-octahedral bimetallic Fe/Eu-MOF preparation and dual model sensing of serum alkaline phosphatase (ALP) based on its peroxidase-like property and fluorescence DOI

Wei Shi,

Tian-Ze Li,

Ning Chu

et al.

Materials Science and Engineering C, Journal Year: 2021, Volume and Issue: 129, P. 112404 - 112404

Published: Sept. 1, 2021

Language: Английский

Citations

56
Recent Advances of Upconversion Nanomaterials in the Biological Field DOI Creative Commons

Cunjin Gao,

Pengrui Zheng,

Liu Quan-xiao

et al.

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(10), P. 2474 - 2474

Published: Sept. 22, 2021

Rare Earth Upconversion nanoparticles (UCNPs) are a type of material that emits high-energy photons by absorbing two or more low-energy caused the anti-stokes process. It can emit ultraviolet (UV) visible light near-infrared (NIR) luminescence upon NIR excitation. Due to its excellent physical and chemical properties, including exceptional optical stability, narrow emission band, enormous Anti-Stokes spectral shift, high penetration in biological tissues, long luminescent lifetime, signal-to-noise ratio, it shows prodigious application potential for bio-imaging photodynamic therapy. This paper will briefly introduce mechanism upconversion (UCL) focus on their research progress achievements bio-imaging, bio-detection,

Language: Английский

Citations

54
Catalytic radiosensitization: Insights from materials physicochemistry DOI Creative Commons
Ya Wang, Huilin Zhang, Yanyan Liu

et al.

Materials Today, Journal Year: 2022, Volume and Issue: 57, P. 262 - 278

Published: June 16, 2022

Language: Английский

Citations

33
Ultrasound combined with nanomaterials for cancer therapy DOI Creative Commons
Yao Zhu, Yingying Liu, Karim Khan

et al.

Materials Today Advances, Journal Year: 2022, Volume and Issue: 17, P. 100330 - 100330

Published: Dec. 15, 2022

Ultrasound (US) is considered as a secure external stimulation for different biomedical applications because it non-invasive, non-toxic and brings no radiation pollution. Compared with traditional ultrasonography application, US has now attracted more attention cancer therapy. It treats in deeper tissues penetrates far than light does. New types of nanomaterials have been developed triggered The study on emerging therapeutic modality by also increasing, e.g., high intensity-focused ultrasound (HIFU) therapy, sonodynamic therapy (SDT), US-mediated drug delivery. research current advances nanomaterials-based US-triggered treatments discussed detail this review, especially the underlying mechanisms better effectiveness. Furthermore, challenges prospective evolution US-based fields were explained. anticipated that our manifestation expanding discipline will aid advancement basic applications.

Language: Английский

Citations

31
Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy DOI Creative Commons
Yanan Hao,

Cong-Cong Qu,

Yang Shu

et al.

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(7), P. 1843 - 1843

Published: July 16, 2021

The emerging chemodynamic therapy (CDT) has received an extensive attention in recent years. However, the efficiency of CDT is influenced due to limitation H

Language: Английский

Citations

36
Exploration of copper-cysteamine nanoparticles as an efficient heterogeneous Fenton-like catalyst for wastewater treatment DOI
Nil Kanatha Pandey,

H.B. Li,

Lalit Chudal

et al.

Materials Today Physics, Journal Year: 2021, Volume and Issue: 22, P. 100587 - 100587

Published: Dec. 3, 2021

Language: Английский

Citations

34