Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Versatile polyphenolic platforms in regulating cell biology

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(10), P. 4175 - 4198

Published: Jan. 1, 2022

Polyphenolic materials are a class of fascinating and versatile bioinspired for biointerfacial engineering. In particular, due to the presence active chemical groups, series unique physicochemical properties become accessible tunable as-prepared polyphenolic platforms, which could delicately regulate cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols also affect behaviors contact-independent manner, arise their intrinsically functional characteristics (e.g., antioxidant photothermal behaviors). As such, comprehensive understanding on relationship between material desired biomedical applications, as well underlying mechanism at cellular molecular level would provide design principles accelerate lab-to-clinic translation platforms. this review, we firstly give brief overview hallmarks governed by surrounding cues, followed introduction engineering strategies. Subsequently, detailed discussion cell-polyphenols interfacial interaction was carefully provided. Lastly, applications were elaborated. We believe that review guidances rational multifunctional extend application window.

Language: Английский

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A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 299 - 312

Published: Sept. 13, 2022

To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction immunogenic cell death (ICD) at tumor sites can increase antigenicity and adjuvanticity to activate microenvironment so that tumors become sensitive intervention inhibitors. Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation epirubicin (EPI), glucose oxidase (Gox) hemin ZIF-8 nanoparticles coating with calreticulin (CRT) over-expressed membrane. EPI acts an ICD inducer, Gox medicate cascade generation reactive oxygen species (ROS) strengthen effect, CRT-rich membrane "eat me" signal promote presentation released antigens dendritic cells (DCs) invoke tumor-immunity cycle. The delivery system displays amplified effect via oxidation, hydroxyl radical glutathione (GSH) depletion. induced potent promotes DCs maturation cytotoxic T lymphocytes (CTLs) infiltration, reversing immunoresponsive one. Treatment nanosystem combination results distinctive inhibition growth lung metastasis, supporting significantly boost therapeutic efficacy antibody. This nanoplatform offers promising means raising

Language: Английский

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Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 183, P. 114177 - 114177

Published: March 1, 2022

Language: Английский

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Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 31, 2022

Abstract The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable revolutionizing health care by improving efficacy, bioavailability, drug targeting, safety. NPs are intriguing when considering medical applications because their essential unique qualities, including a significantly higher surface to mass ratio, quantum properties, the potential adsorb transport drugs other compounds. However, must overcome or navigate several biological barriers human body successfully deliver at precise locations. Engineering carrier biointerface can help main optimize delivery in more personalized manner. This review discusses significant heterogeneous how engineering promote carriers prevail over hurdles manner, thus ushering era Precision Medicine. We also summarize nanomedicines' current advantages disadvantages administration, from natural/synthetic sources clinical applications. Additionally, we explore innovative NP designs used both non-personalized customized as well they attain therapeutic strategy.

Language: Английский

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Research progress on self-assembled nanodrug delivery systems

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(12), P. 1908 - 1922

Published: Jan. 1, 2022

This review summarizes the research progress and applications of different types self-assembled nanodrug delivery systems, which are expected to have potential therapeutic value in field biomedicine future.

Language: Английский

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Carrier-Free Immunotherapeutic Nano-Booster with Dual Synergistic Effects Based on Glutaminase Inhibition Combined with Photodynamic Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1583 - 1596

Published: Jan. 3, 2023

The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism prevented PDT-generated reactive oxygen species from being annihilated GSH, amplifying intracellular oxidative stress, which caused severe cell death also enhanced immunogenic (ICD) effect. In addition, genome-wide analysis carried out using RNA-sequencing to evaluate changes in transcriptome induced stress. Thereafter, neoantigens generated ICD promoted maturation dendritic cells, thereby recruiting activating cytotoxic T lymphocytes (CTLs). Meanwhile, remodeled ITM blocking polarize M2-type tumor-associated macrophages (TAMs) into M1-type TAMs, further recruited activated CTLs. Ultimately, this suppressed primary distant tumors. This "kill two birds one stone" strategy would shed light on enhancing immunogenicity alleviating immunosuppression improve PDT.

Language: Английский

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Carrier-Free Nanodrug Based on Co-Assembly of Methylprednisolone Dimer and Rutin for Combined Treatment of Spinal Cord Injury

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12176 - 12187

Published: June 30, 2023

Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration and accumulation of oxidative substance, would severely impede neurological functional recovery lead to permanent profound neurologic deficits even disability. Methylprednisolone (MP) the most commonly used clinical anti-inflammatory drug for SCI treatment, but high doses are typically required that can cause severe side effects. Here, we developed a carrier-free thioketal linked MP dimer@rutin nanoparticles (MP2-TK@RU NPs) achieve combined treatment coassembling reactive oxygen species (ROS) cleavable dimers rutin. This proposed nanodrug possesses following favorable advantages: (1) system easily accessible has drug-loading capacity, preferred pharmaceutical industry; (2) The ROS-cleavable linker increases efficiency targeted delivery site; (3) Rutin, type plant-derived natural flavonoid with good biocompatibility, anti-inflammatory, antioxidant properties, codelivered enhance therapy outcomes. obtained MP2-TK@RU NPs exhibited potent antioxidative properties both in vitro vivo, demonstrating superior locomotor function neuroprotective efficacy rats SCI. anticipated provide promising therapeutic strategy treatment.

Language: Английский

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Recent Applications of PLGA in Drug Delivery Systems

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2606 - 2606

Published: Sept. 14, 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.

Language: Английский

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Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1076 - 1076

Published: Aug. 16, 2024

Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient unsafe delivery systems severe side effects, impeded the widespread use medicine. The purpose drug (DDSs) is to regulate time place release action. They aid enhancing equilibrium between medicinal efficacy on target hazardous effects off target. One promising approach biomaterial-assisted biotherapy, which takes advantage biomaterials’ special capabilities, high biocompatibility bioactive characteristics. When administered via different routes, molecules deal biological barriers; DDSs help them overcome these hurdles. With their adaptable features ample packing capacity, biomaterial-based allow for targeted, localised, prolonged medications. Additionally, they are being investigated more controlling interface host tissue implanted biomedical materials. This review discusses innovative nanoparticle designs non-personalised applications improve therapies. We prioritised design trends address heterogeneous barriers, because we believe intelligent can patient outcomes by enabling improving general efficacy. additionally reviewed most recent literature biomaterials used biotherapy vaccine development, covering delivery, stem cell therapy, gene other similar fields; also addressed difficulties future biotherapies.

Language: Английский

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