Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Jan. 5, 2024
This
review
article
explores
the
dynamic
field
of
radiopharmaceuticals,
where
innovative
developments
arise
from
combining
radioisotopes
and
pharmaceuticals,
opening
up
exciting
therapeutic
possibilities.
The
in-depth
exploration
covers
targeted
drug
delivery,
delving
into
passive
targeting
through
enhanced
permeability
retention,
as
well
active
using
ligand-receptor
strategies.
also
discusses
stimulus-responsive
release
systems,
which
orchestrate
controlled
release,
enhancing
precision
effectiveness.
A
significant
focus
is
placed
on
crucial
role
radiopharmaceuticals
in
medical
imaging
theranostics,
highlighting
their
contribution
to
diagnostic
accuracy
image-guided
curative
interventions.
emphasizes
safety
considerations
strategies
for
mitigating
side
effects,
providing
valuable
insights
addressing
challenges
achieving
precise
delivery.
Looking
ahead,
nanoparticle
formulations
cutting-edge
innovations
next-generation
showcasing
potential
applications.
Real-world
examples
are
presented
case
studies,
including
use
radiolabelled
antibodies
solid
tumors,
peptide
receptor
radionuclide
therapy
neuroendocrine
intricate
management
bone
metastases.
concluding
perspective
envisions
future
trajectory
anticipating
a
harmonious
integration
medicine
artificial
intelligence.
vision
foresees
an
era
aligns
seamlessly
with
scientific
advancements,
ushering
new
epoch
marked
by
fusion
resonance
visionary
progress.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 7, 2024
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(3), P. 1167 - 1315
Published: Jan. 1, 2024
Silicon-based
biomaterials
have
been
extensively
developed
in
the
past
decades.
The
classification,
characteristics,
multi-dimensional
design,
and
biomedical
applications
of
silicon-containing
are
comprehensively
elaborated.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(6), P. 1966 - 2006
Published: Jan. 1, 2024
Neoplasias
pose
a
significant
threat
to
aging
society,
underscoring
the
urgent
need
overcome
limitations
of
traditional
chemotherapy
through
pioneering
strategies.
Targeted
drug
delivery
is
an
evolving
frontier
in
cancer
therapy,
aiming
enhance
treatment
efficacy
while
mitigating
undesirable
side
effects.
One
promising
avenue
utilizes
cell
membrane
receptors
like
folate
receptor
guide
transporters
precisely
malignant
cells.
Based
on
cellular
as
hallmark,
targeted
nanocarriers
and
small
molecule-drug
conjugates
have
been
developed
that
comprise
different
(bio)
chemistries
and/or
mechanical
properties
with
individual
advantages
challenges.
Such
modern
folic
acid-conjugated
stimuli-responsive
provide
systemic
controlled
release,
enabling
reduced
dosages,
circumvention
resistance,
diminished
adverse
Since
transporters'
structure-based
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
670, P. 125186 - 125186
Published: Jan. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
