Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Abstract
The
heavy
dependence
on
intratumoral
O
2
and
H
availability
has
greatly
restricted
ROS‐based
therapy.
Although
/H
‐irrelevant
free‐radical
nanogenerator
garnered
tremendous
attention
as
a
promising
anticancer
candidate
to
overcome
the
above
intrinsic
limitations
of
treatment,
practical
therapeutic
efficacy
therapy
is
still
hindered
by
limited
type
inferior
tumor
retention
performance.
Herein,
inspired
new
concept
full‐API
nanodrug
(FAND)
with
100%
active
pharmaceutical
ingredient
(API)
content
repurposing
clinical
anti‐malaria
drug
artesunate
(ARTE)
an
generator,
AFeI
FANDs
composed
ARTE,
human
essential
Fe
3+
,
FDA‐approved
fluorescent
agent
ICG
for
hypoxic
are
rationally
designed
constructed.
Attractively,
completely
pharmaceutically
components
can
be
responsively
liberated
in
acidic
microenvironment
synergistically
produce
five
types
free
radicals
including
•O
−
•C,
•OH,
LOO•,
1
leading
robust
mitochondrial
injury,
nuclear
DNA
damage,
lipid
peroxides.
More
importantly,
displayed
ultralong
longer
than
108
h
favorable
suppression
outcomes
under
mild
NIR
irradiation.
Collectively,
presented
first
paradigm
FAND‐based
quintuple
expands
horizons
development
clinically
transferable
nanomedicine
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: March 8, 2024
Abstract
Glutamine
metabolism
plays
a
pivotal
role
in
cancer
progression,
immune
cell
function,
and
the
modulation
of
tumor
microenvironment.
Dysregulated
glutamine
has
been
implicated
development
responses,
supported
by
mounting
evidence.
Cancer
cells
heavily
rely
on
as
critical
nutrient
for
survival
proliferation,
while
require
activation
proliferation
during
reactions.
This
metabolic
competition
creates
dynamic
tug-of-war
between
cells.
Targeting
transporters
downstream
enzymes
involved
holds
significant
promise
enhancing
anti-tumor
immunity.
A
comprehensive
understanding
intricate
molecular
mechanisms
underlying
this
interplay
is
crucial
developing
innovative
therapeutic
approaches
that
improve
immunity
patient
outcomes.
In
review,
we
provide
overview
recent
advances
unraveling
explore
potential
applications
basic
science
discoveries
clinical
setting.
Further
investigations
into
regulation
are
expected
to
yield
valuable
insights,
paving
way
future
interventions.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Amino
acid
metabolism
plays
a
pivotal
role
in
tumor
microenvironment,
influencing
various
aspects
of
cancer
progression.
The
metabolic
reprogramming
amino
acids
cells
is
intricately
linked
to
protein
synthesis,
nucleotide
modulation
signaling
pathways,
regulation
cell
metabolism,
maintenance
oxidative
stress
homeostasis,
and
epigenetic
modifications.
Furthermore,
the
dysregulation
also
impacts
microenvironment
immunity.
can
act
as
molecules
that
modulate
immune
function
tolerance
within
reshaping
anti-tumor
response
promoting
evasion
by
cells.
Moreover,
influence
behavior
stromal
cells,
such
cancer-associated
fibroblasts,
regulate
ECM
remodeling
promote
angiogenesis,
thereby
facilitating
growth
metastasis.
Understanding
intricate
interplay
between
crucial
significance.
Expanding
our
knowledge
multifaceted
roles
holds
significant
promise
for
development
more
effective
therapies
aimed
at
disrupting
dependencies
modulating
enhance
responses
inhibit
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 6, 2025
Reactive
oxygen
species
(ROS)
is
promising
in
cancer
therapy
by
accelerating
tumor
cell
death,
whose
therapeutic
efficacy,
however,
greatly
limited
the
hypoxia
microenvironment
(TME)
and
antioxidant
defense.
Amplification
of
oxidative
stress
has
been
successfully
employed
for
therapy,
but
interactions
between
cells
other
factors
TME
usually
lead
to
inadequate
treatments.
To
tackle
this
issue,
we
develop
a
pH/redox
dual-responsive
nanomedicine
based
on
remodeling
cancer-associated
fibroblasts
(CAFs)
multi-pronged
amplification
ROS
(ZnPP@FQOS).
It
demonstrated
that
generated
ZnPP@FQOS
endogenously/exogenously
multiply
amplified
owing
CAFs
down-regulation
anti-oxidative
cells,
ultimately
achieving
efficient
photodynamic
female
tumor-bearing
mouse
model.
More
importantly,
verified
enable
stimulation
enhanced
immune
responses
systemic
immunity.
This
strategy
remarkably
potentiates
efficacy
photodynamic-immunotherapy,
thus
providing
enlightenment
therapy.
The
reactive
Here,
authors
address
these
limitations
developing
microenvironment-responsive
hybrid
associated
ROS.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic
cell
death
(ICD)
is
a
unique
mode
of
death,
which
can
release
immunogenic
damage-associated
molecular
patterns
(DAMPs)
and
tumor-associated
antigens
to
trigger
long-term
protective
antitumor
immune
responses.
Thus,
amplifying
"eat
me
signal"
during
tumor
ICD
cascade
critical
for
cancer
immunotherapy.
Some
therapies
(radiotherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
etc.)
inducers
(chemotherapeutic
agents,
have
enabled
initiate
and/or
facilitate
activate
Recently,
nanostructure-based
drug
delivery
systems
been
synthesized
inducing
through
combining
treatment
chemotherapeutic
photosensitizers
PDT,
transformation
agents
PTT,
radiosensitizers
radiotherapy,
etc.,
loaded
at
an
appropriate
dosage
in
the
designated
place
time,
contributing
higher
efficiency
lower
toxicity.
Also,
immunotherapeutic
combination
with
produce
synergetic
effects,
thus
potentiating
Overall,
our
review
outlines
emerging
inducers,
nanostructure
loading
diverse
evoke
chemoradiotherapy,
PTT
or
agents.
Moreover,
we
discuss
prospects
challenges
harnessing
induction-based
immunotherapy,
highlight
significance
multidisciplinary
interprofessional
collaboration
promote
optimal
translation
this
strategy.
Aggregate,
Journal Year:
2023,
Volume and Issue:
5(1)
Published: Oct. 12, 2023
Abstract
Nowadays,
cancer
has
become
the
leading
cause
of
death
worldwide,
driving
need
for
effective
therapeutics
to
improve
patient
prognosis.
Photodynamic
therapy
(PDT)
been
widely
applied
as
an
antitumor
modality,
owing
its
minimal
invasiveness,
localized
tumor
damage,
and
high
safety
profile.
However,
efficacy
is
limited
by
poor
stability
photosensitizers,
inadequate
accumulation,
a
complex
microenvironment.
To
overcome
these
challenges,
extensive
endeavors
have
made
explore
co‐assembly
used
photosensitizer
chlorin
e6
(Ce6)
with
various
functional
small
molecules
enhance
pharmacodynamic
activity.
This
review
provides
comprehensive
overview
current
studies
on
Ce6‐based
nanoparticles
PDT
precise
delivery
molecules.
The
self‐assembly
mechanism
will
be
discussed
in
detail,
focus
potential
strategies
combinational
PDT.
Small,
Journal Year:
2023,
Volume and Issue:
20(16)
Published: Nov. 28, 2023
Abstract
Photodynamic
therapy
(PDT)
has
recently
been
considered
a
potential
tumor
due
to
its
time‐space
specificity
and
non‐invasive
advantages.
PDT
can
not
only
directly
kill
cells
by
using
cytotoxic
reactive
oxygen
species
but
also
induce
an
anti‐tumor
immune
response
causing
immunogenic
cell
death
of
cells.
Although
it
exhibits
promising
prospect
in
treating
tumors,
there
are
still
many
problems
be
solved
practical
application.
Tumor
hypoxia
immunosuppressive
microenvironment
seriously
affect
the
efficacy
PDT.
The
hypoxic
is
mainly
abnormal
vascular
matrix
around
tumor,
metabolism,
influence
various
immunosuppressive‐related
their
expressed
molecules.
Thus,
reprogramming
(TME)
great
significance
for
rejuvenating
This
article
reviews
latest
strategies
PDT,
from
regulating
matrix,
interfering
with
related
factors
reverse
microenvironment.
These
provide
valuable
information
better
understanding
TME
guide
development
next‐generation
multifunctional
nanoplatforms
