International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5249 - 5249
Published: May 11, 2024
In
clinical
practice,
tissue
adhesives
have
emerged
as
an
alternative
tool
for
wound
treatments
due
to
their
advantages
in
ease
of
use,
rapid
application,
less
pain,
and
minimal
damage.
Since
most
are
designed
internal
use
or
treatments,
the
biodegradation
is
important.
To
endow
with
biodegradability,
past
few
decades,
various
biodegradable
polymers,
either
natural
polymers
(such
chitosan,
hyaluronic
acid,
gelatin,
chondroitin
sulfate,
starch,
sodium
alginate,
glucans,
pectin,
functional
proteins,
peptides)
synthetic
poly(lactic
acid),
polyurethanes,
polycaprolactone,
poly(lactic-co-glycolic
acid)),
been
utilized
develop
novel
adhesives.
Incorporated
degraded
vivo
time
under
specific
conditions,
leading
destruction
structure
further
degradation
this
review,
we
first
summarize
strategies
utilizing
Furthermore,
provide
a
symmetric
overview
used
adhesives,
focus
on
degradability
applications
these
Additionally,
challenges
perspectives
polymer-based
discussed.
We
expect
that
review
can
new
inspirations
design
biomedical
applications.
Fundamental Research,
Journal Year:
2023,
Volume and Issue:
4(5), P. 1243 - 1253
Published: May 30, 2023
Cell-free
wound
dressings
(WDs)
with
desirable
effectiveness
and
safety
have
received
much
attention
in
the
field
of
regenerative
medicine.
However,
weak
linkages
between
bioactive
polymers
spatial
structure
WDs
frequently
result
interventional
treatment
failure.
Herein,
we
create
a
series
quaternized
chitosan
(QCS)-incorporated
composite
hydrogels
(referred
to
as
GHCH-n)
by
UV
cross-linking
then
convert
them
into
microneedle
patches
(MNPs).
QCS,
which
is
positively
charged
amphiphilic,
essential
for
broad-spectrum
antibacterial
haemostatic
activities.
QCS
proven
be
slightly
toxic,
so
it
immobilized
methacrylate
gelatine
(GelMA)
molecular
cage
minimize
adverse
effects.
A
polydimethylsiloxane
micro-mould
used
shape
MNPs.
MNPs
can
pierce
tissue,
seal
off
bleeding
sites,
cling
wounds
securely.
Thus,
cooperate
GHCH-n
halt
accelerate
healing.
This
study
recommends
GHCH-10
an
advanced
biomaterial.
Several
preclinical
research
models
thoroughly
validated
application
effect
also
proposes
novel
strategy
integrating
nature
biomaterials.
not
only
applicable
fabrication
next-generation
but
shows
great
potential
expanding
interdisciplinary
domains.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5249 - 5249
Published: May 11, 2024
In
clinical
practice,
tissue
adhesives
have
emerged
as
an
alternative
tool
for
wound
treatments
due
to
their
advantages
in
ease
of
use,
rapid
application,
less
pain,
and
minimal
damage.
Since
most
are
designed
internal
use
or
treatments,
the
biodegradation
is
important.
To
endow
with
biodegradability,
past
few
decades,
various
biodegradable
polymers,
either
natural
polymers
(such
chitosan,
hyaluronic
acid,
gelatin,
chondroitin
sulfate,
starch,
sodium
alginate,
glucans,
pectin,
functional
proteins,
peptides)
synthetic
poly(lactic
acid),
polyurethanes,
polycaprolactone,
poly(lactic-co-glycolic
acid)),
been
utilized
develop
novel
adhesives.
Incorporated
degraded
vivo
time
under
specific
conditions,
leading
destruction
structure
further
degradation
this
review,
we
first
summarize
strategies
utilizing
Furthermore,
provide
a
symmetric
overview
used
adhesives,
focus
on
degradability
applications
these
Additionally,
challenges
perspectives
polymer-based
discussed.
We
expect
that
review
can
new
inspirations
design
biomedical
applications.
