Antibacterial coatings on orthopedic implants

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100586 - 100586

Published: Feb. 15, 2023

With the aging of population and rapid improvement public health medical level in recent years, people have had an increasing demand for orthopedic implants. However, premature implant failure postoperative complications frequently occur due to implant-related infections, which not only increase social economic burden, but also greatly affect patient's quality life, finally restraining clinical use Antibacterial coatings, as effective strategy solve above problems, been extensively studied motivated development novel strategies optimize implant. In this paper, a variety antibacterial coatings recently developed implants were briefly reviewed, with focus on synergistic multi-mechanism multi-functional smart that are more potential use, thereby providing theoretical references further fabrication high-performance satisfying complex needs.

Language: Английский

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Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1172 - 1172

Published: March 6, 2024

Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance antimicrobial agents immune system. Thus, viable options eradicate embedded on medical implants are surgical operations long-term repeated antibiotic courses. Recent years have witnessed growing interest in development robust reliable strategies for prevention treatment IAIs. In particular, it seems promising develop materials with anti-biofouling antibacterial properties combating IAIs implants. this contribution, we exclusively focus recent advances modified functionalized implant surfaces inhibiting bacterial attachment eventually biofilm formation orthopedic Further, highlight progress coatings (including self-assembled nanocoatings) preventing Among recently introduced approaches efficient durable coatings, use safe biocompatible excellent activities local delivery combinatorial treating overcoming resistance.

Language: Английский

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Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2703 - 2724

Published: April 22, 2024

The scientific world is increasingly focusing on rare earth metal oxide nanomaterials due to their consequential biological prospects, navigated by breakthroughs in biomedical applications. Terbium belongs elements (lanthanide series) and possesses remarkably strong luminescence at lower energy emission signal transduction properties, ushering wide applications for diagnostic measurements (i.e., bioimaging, biosensors, fluorescence imaging, etc.) the sectors. In addition, theranostic of terbium-based nanoparticles further permit targeted delivery drugs specific site disease. Furthermore, antimicrobial properties terbium induced via reactive oxygen species (ROS) cause oxidative damage cell membrane nuclei living organisms, ion release, surface charge interaction, thus creating or exhibiting excellent antioxidant characteristics. Moreover, recent tissue engineering, wound healing, anticancer activity, etc., angiogenesis, proliferation, promotion growth factors, biocompatibility, cytotoxicity mitigation, anti-inflammatory potentials, make this nanoparticle anticipate a future epoch nanomaterials. stand as game changer realm research, proffering array possibilities, from revolutionary imaging techniques advanced drug systems. Their unique including luminescence, magnetic characteristics, have redefined boundaries what can be achieved biomedicine. This review primarily delves into various mechanisms involved physicochemical article explains potential with in-depth significant individual literature. additionally stands first instance furnish "single-platted" comprehensive acquaintance shaping healthcare well limitations overcoming strategies that require exploration before being trialed clinical settings.

Language: Английский

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Poly (Ether-Ether-Ketone) for Biomedical Applications: From Enhancing Bioactivity to Reinforced-Bioactive Composites—An Overview

Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 373 - 373

Published: Jan. 10, 2023

The global orthopedic market is forecasted to reach US$79.5 billion by the end of this decade. Factors driving increase in are population aging, sports injury, road traffic accidents, and overweight, which justify a growing demand for implants. Therefore, it utmost importance develop bone implants with superior mechanical biological properties face improve patients’ quality life. Today, metallic still hold dominant position implant market, mainly due their resistance. However, performance might be jeopardized possible release debris, leading cytotoxic effects inflammatory responses body. Poly (ether-ether-ketone) (PEEK) biocompatible, high-performance polymer one most prominent candidates used manufacturing its similarity bone. Unfortunately, bioinert nature PEEK culminates diminished osseointegration. Notwithstanding, PEEK’s bioactivity can improved through surface modification techniques development bioactive composites. This paper overviews advantages using addresses common strategies order promote enhanced biomechanical performance.

Language: Английский

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A Versatile Hydrogel with Antibacterial and Sequential Drug-Releasing Capability for the Programmable Healing of Infectious Keratitis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 24055 - 24069

Published: Dec. 4, 2023

Hydrogels have attracted tremendous attention as favorable corneal substitutes for treating severe infectious keratitis (IK). However, current hydrogel-based were majorly designed to promote the single stage of regeneration, which falls short in meeting clinical management needs IK including multiple phases wound healing. Herein, we introduce a versatile hybrid hydrogel (SQPV) composed silk fibroin and chitosan, exhibits spatiotemporal properties drug release. The SQPV is fabricated by incorporating verteporfin-loaded poly(lactic-co-glycolic)-polyethylene glycol-o-nitrobenzene micelles into network, formed from methacrylate glycidyl functionalized quaternized chitosan containing polydeoxyribonucleotide. This double network approach results material with exceptional anti-inflammatory, antibacterial, proliferative stimulation tissue remodeling regulation capabilities. Furthermore, showcases mechanical strength transparency akin those native cornea. Extensive vitro vivo studies validate SQPV's ability effectively eliminate residual bacteria, mitigate inflammation, foster regeneration epithelium stroma, prevent scarring, ultimately expedite In summary, SF/CS-based may represent promising substitute comprehensive repair IK.

Language: Английский

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A comprehensive review on potential applications of metallic nanoparticles as antifungal therapies to combat human fungal diseases

Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(9), P. 101733 - 101733

Published: Aug. 6, 2023

Human pathogenic fungi are responsible for causing a range of infection types including mucosal, skin, and invasive infections. Life-threatening fungal infections (FIs) mortality morbidity, especially individuals with compromised immune function. The number currently available therapeutic agents against FIs is limited compared to that bacterial In addition, the increased morbidity caused by linked antifungal agents, resistance, toxicity these agents. Currently have several drawbacks in efficiency, efficacy, toxicity, activity spectrum, selectivity. It has already been demonstrated numerous metallic nanoparticles (MNPs) can serve as an effective alternative solution fungicidal MNPs great potential owing their intrinsic properties deliver drugs. For instance, gold (AuNPs) capacity disturb mitochondrial calcium homeostasis induced AuNP-mediated cell death Candida albicans. both copper oxide exerted significant suppressive fungi. Silver showed strong fungi, such Stachybotrys chartarum, Mortierella alpina, Chaetomium globosum, A. fumigatus, Cladosporium cladosporioides, Penicillium brevicompactum, Trichophyton rubrum, C. tropicalis, Iron potent activities niger P. chrysogenum. also reported zinc significantly inhibit growth. These NPs species Candida, Aspergillus, Fusarium, many others. Several strategies used research development chemical modification combination This review comprehensively presented current innovative approach using MNPs. Moreover, different MNPs, physicochemical characteristics, production techniques summarized this review.

Language: Английский

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Nanocomposites against Pseudomonas aeruginosa biofilms: Recent advances, challenges, and future prospects

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127656 - 127656

Published: Feb. 28, 2024

Language: Английский

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Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Language: Английский

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Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.

Language: Английский

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Recent development of dental implant materials, synthesis process, and failure – A review

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101136 - 101136

Published: Sept. 22, 2023

In modern medicine, implants have become a prevalent solution for replacing or supporting damaged body parts across various specialties, from orthopedics to dentistry.However, implant failure remains significant concern despite surgical and technology improvements. This in-depth review aims give an overview of materials used in implants, the synthesis process dental its causes, related clinical implications. The explores failures, including biological shortcomings (infection soft tissue complications) reasons. addition, it outlinesdifferent treatment options dealing with failure. It also discusses difficulties that healthcare professionals face managing failed implants.The comes close by emphasizing need more investigation into underlying causes creation preventative measures. highlights value interdisciplinary cooperation between clinicians, engineers, researchers raise patient's quality life increase success rates.

Language: Английский

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