Towards load-bearing biomedical titanium-based alloys: From essential requirements to future developments

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101277 - 101277

Published: March 8, 2024

The use of biomedical metallic materials in research and clinical applications has been an important focus a significant area interest, primarily owing to their role enhancing human health extending lifespan. This article, particularly on titanium-based alloys, explores exceptional properties that can address bone issues amid the growing challenges posed by aging population. Although stainless steel, magnesium-based cobalt-based other are commonly employed medical applications, limitations such as toxic elements, high elastic modulus, rapid degradation rates limit widespread applications. Therefore, alloys have emerged top-performing materials, gradually replacing counterparts various article extensively examines highlights along with in-depth discussion currently utilized inherent limitations. To begin with, essential requirements for load-bearing biomaterials introduced. Then, summarized compared. Afterward, microstructure, properties, preparations explored. Furthermore, surface modification methods discussed enhance biocompatibility, wear resistance corrosion resistance. Finally, proposes development path conjunction additive manufacturing novel alloy nitinol.

Language: Английский

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Zinc and melatonin mediated antimicrobial, anti-inflammatory, and antioxidant coatings accelerate bone defect repair

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: unknown, P. 114335 - 114335

Published: Oct. 1, 2024

Language: Английский

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Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1172 - 1172

Published: March 6, 2024

Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance antimicrobial agents immune system. Thus, viable options eradicate embedded on medical implants are surgical operations long-term repeated antibiotic courses. Recent years have witnessed growing interest in development robust reliable strategies for prevention treatment IAIs. In particular, it seems promising develop materials with anti-biofouling antibacterial properties combating IAIs implants. this contribution, we exclusively focus recent advances modified functionalized implant surfaces inhibiting bacterial attachment eventually biofilm formation orthopedic Further, highlight progress coatings (including self-assembled nanocoatings) preventing Among recently introduced approaches efficient durable coatings, use safe biocompatible excellent activities local delivery combinatorial treating overcoming resistance.

Language: Английский

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A review on antimicrobial strategies in mitigating biofilm-associated infections on medical implants

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 6, P. 100231 - 100231

Published: Jan. 1, 2024

Biomedical implants are crucial in providing support and functionality to patients with missing or defective body parts. However, carry an inherent risk of bacterial infections that biofilm-associated lead significant complications. These often result implant failure, requiring replacement by surgical restoration. Given these complications, it is study the biofilm formation mechanism on various biomedical will help prevent failures. Therefore, this comprehensive review explores types (e.g., dental implant, orthopedic tracheal stent, breast central venous catheter, cochlear urinary intraocular lens, heart valve) medical devices (hemodialyzer pacemaker) use. In addition, those implants, their pathogenesis were discussed. Furthermore, article critically reviews approaches combating implant-associated infections, a special emphasis novel non-antibiotic alternatives mitigate infections.

Language: Английский

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Hybrid coatings on dental and orthopedic titanium implants: Current advances and challenges

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Abstract Dental and orthopedic titanium implants are successfully widely used but still face challenges due to complications leading high treatment cost, morbidity, even mortality. This review focuses on the hybrid coatings designed prevent mitigate implant failure by integrating multiple strategies materials. The forms of manufacturing synthesizing were first discussed. We then categorize these based their biological functions: antibacterial coatings, which essential for preventing difficult‐to‐treat infection; promote osseointegration, crucial mechanical stability implants; that encourage soft tissue attachment, contributing overall success esthetics implant. summarize state art in multifunctional integrate functions as an alternative, holistic approach reducing complications. culminates a discussion future directions field, emphasizing potential notable biofunctional toward obtaining commercial patients. Together, our article provides comprehensive overview current developments glimpse into potentially revolutionizing dental implants.

Language: Английский

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Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 45, P. 24 - 35

Published: March 1, 2024

Fracture-related infection (FRI) remains a major concern in orthopaedic trauma. Functionalizing implants with antibacterial coatings are promising strategy mitigating FRI. Numerous implant have been reported but the preventive and therapeutic effects vary. This systematic review aimed to provide comprehensive overview of current coating strategies prevent treat FRI animal fracture bone defect models. A literature search was performed three databases: PubMed, Web Science Embase, predetermined keywords criteria up 28 February 2023. Preclinical studies on or models that assessed healing were included. total 14 included this review, seven which used Passive bacteria adhesion resistance investigated two studies. Active bactericidal 12 studies, four metal ions including Ag+ Cu2+; five antibiotics chlorhexidine, tigecycline, vancomycin, gentamicin sulfate; other natural materials chitosan, antimicrobial peptides, lysostaphin. Overall, these exhibited efficacy formation. Antibacterial reduced bacterial infections favored vivo. Future should focus optimal biocompatibility, against multi-drug resistant polymicrobial infections, osseointegration osteogenesis promotion especially osteoporotic by constructing multi-functional for therapy. The clinical treatment is complex challenging. summarizes novel applied preclinical offers perspective future development coatings, can potentially contribute alternative practice.

Language: Английский

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Freestanding Nanofiber‐Assembled Aptasensor for Precisely and Ultrafast Electrochemical Detection of Alzheimer's Disease Biomarkers

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)

Published: Feb. 22, 2024

Abstract Amyloid beta‐protein (AβA β ) is a main hallmark of Alzheimer's disease (AD), and low amount Aβ protein accumulation appears to be potential marker for AD. Here, an electrochemical DNA biosensor based on polyamide/polyaniline carbon nanotubes (PA/PANI‐CNTs) developed with the aim diagnosing AD early using simple, low‐cost, accessible method rapidly detect Aβ42 in human blood. Electrospun PA nanofibers served as skeleton successive situ deposition PANI CNTs, which contribute both high conductivity abundant binding sites aptamers. After aptamers are immobilized, this aptasensor exhibits precise specific detection blood within only 4 min extremely fast response rate, lower limit, excellent linear range. These findings make significant contribution advancing development serum‐based techniques Aβ42, thereby paving way improved diagnostic capabilities field

Language: Английский

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Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129210 - 129210

Published: Jan. 4, 2024

Bone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined drug delivery phototherapy. Herein, Fab@Home Plotter printer was promote layer-by-layer deposition of composite mixture gelatin, chitosan, tricalcium phosphate, reduced graphene oxide (rGO). The phototherapeutic potential new NIR-responsive 3D_rGO scaffolds assessed by comparing different rGO concentrations (1, 2, 4 mg/mL). data obtained show incorporation confers interact NIR light induce hyperthermy effect, maximum temperature increase 16.7 °C after under irradiation (10 min). Also, in content improved hydrophilicity mechanical resistance scaffolds, particularly 3D_rGO4. Furthermore, could confer an NIR-triggered antibacterial effect without compromising osteoblasts' proliferation viability. In general, support development being applied as temporary supporting formation avoiding establishment bacterial infections.

Language: Английский

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Engineering antibacterial bioceramics: Design principles and mechanisms of action

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101069 - 101069

Published: April 27, 2024

The urgency to address skeletal abnormalities and diseases through innovative approaches has led a significant interdisciplinary convergence of engineering, 3D printing, design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements future trajectory non-antibiotic antibacterial bioceramics bone tissue an importance given escalating challenges orthopaedic infections, antibiotic resistance, emergent pathogens. Initially, provides in-depth exploration complex interactions among bacteria, immune cells, clinical contexts, highlighting multifaceted nature infection dynamics, including protein adsorption, immunological responses, bacterial adherence, endotoxin release. Then, focus on next-generation designed offer multifunctionality, especially delivering properties independent traditional antibiotics. A key highlight this study is smart bioceramics, marking revolutionary stride medical implant technology. also aims guide ongoing development adoption materials, focusing their dual capabilities promoting regeneration exhibiting properties. These represent paradigm shift technology, offering multifunctional benefits that transcend approaches.

Language: Английский

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Hydroxyapatite-Based Coatings on Mg and Ti-based Implants: A Detailed Examination of Various Coating Methodologies

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41813 - e41813

Published: Jan. 1, 2025

Metallic implants have been considered as promising alternatives to traditional due their biocompatibility and favorable biodegradability properties. However, one of the major challenges in using these is relatively fast degradation rate metal alloys body's electrolyte environment, which can lead early loss performance release undesirable products. Applying appropriate coatings with suitable on surface be an effective solution control deterioration increase stability body environment. In this comprehensive study, various methods coating calcium phosphate or hydroxyapatite structures, including sol-gel, chemical deposition (such hydrothermal deposition), thermal spraying plasma spray) fully investigated. The benefits drawbacks each techniques relation properties resulting such morphology, composition, adhesion substrate, porosity crystal structure, anti-corrosion performance, impact biological implant terms biocompatibility, control, mechanical properties, well limitations related process are described. results study provide valuable key guidance for choosing most method according type medical application implants.

Language: Английский

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