Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
Postoperative
infections
in
artificial
joints
provide
considerable
difficulties
the
field
of
orthopedics,
especially
after
joint
replacement
procedures.
These
rank
among
most
severe
postoperative
consequences,
frequently
leading
to
treatment
ineffectiveness
and
reduced
quality
life
for
surgery
patients.
Consequently,
it
is
crucial
acquire
knowledge
about
worldwide
research
trends
this
area
order
educate
clinical
practices
improve
therapeutic
techniques.
This
work
exploits
bibliometric
analysis
investigate
present
state,
developing
patterns,
main
areas
focus
on
infection.
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(10), P. 5726 - 5737
Published: May 15, 2024
Catheter-related
infections
are
some
of
the
most
common
acquired
in
hospitals,
and
designing
functional
coatings
on
surface
medical
catheters
to
limit
bacterial
colonization
biofilm
formation
can
be
effective
avoiding
infections.
In
this
study,
a
composite
coating
(PU-PDA-Ag-PDA-PHMG)
with
simultaneous
antifouling,
contact-active,
release-kill
properties
was
prepared
polyurethane
(PU)
surfaces
using
polydopamine,
Ag
nanoparticles,
polyhexamethylene
guanidine.
This
systematically
evaluated
by
studying
its
long-term
hydrophilicity,
antibacterial
property,
antibiofilm
silver
release
rate,
mechanical
biocompatibility.
The
results
scanning
electron
microscopy,
atomic
force
Fourier
transform
infrared
spectrometry,
X-ray
photoelectron
spectroscopy
showed
that
PU-PDA-Ag-PDA-PHMG
multimechanism
successfully
PU
surface.
Relative
value
97.62°
for
unmodified
substrate,
water
contact
angle
increased
from
49.73°
61.68°
after
28
days
deionized
immersion,
indicating
excellent
hydrophilic
properties.
Also,
reduces
protein
adhesion
58.67%.
After
immersion
PBS
solution,
rates
against
Staphylococcus
aureus
Escherichia
coli
still
reached
97.67%
99.5%,
respectively,
broad-spectrum
property
significantly
improved
compared
single-mechanism
coating,
almost
free
any
bacteria.
total
amount
ions
released
about
16.95%
PU-PDA-Ag
within
14
days,
which
proved
could
reduce
rate
ions.
preparation
process
also
did
not
change
original
biocompatibility
(cytotoxicity
level
1).
conclusion,
developed
study
has
great
potential
reducing
catheter-associated
Journal of Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
669, P. 537 - 551
Published: April 27, 2024
Infectious
diseases,
particularly
those
associated
with
biofilms,
are
challenging
to
treat
due
an
increased
tolerance
commonly
used
antibiotics.
This
underscores
the
urgent
need
for
innovative
antimicrobial
strategies.
Here,
we
present
alternative
simple-by-design
approach
focusing
on
development
of
biocompatible
and
antibiotic-free
nanocarriers
from
docosahexaenoic
acid
(DHA)
that
has
potential
combat
microbial
infections
phosphatidylglycerol
(DOPG),
which
is
attractive
use
as
a
prominent
amphiphilic
component
Gram-positive
bacterial
cell
membranes.
We
assessed
anti-bacterial
anti-biofilm
activities
these
nanoformulations
(hexosomes
vesicles)
against
S.
aureus
epidermidis,
most
common
causes
catheters
medical
devices
by
different
methods
(including
resazurin
assay,
time-kill
confocal
laser
scanning
microscopy
in
vitro
catheter
biofilm
model).
In
DHA-concentration-dependent
manner,
nano-self-assemblies
demonstrated
strong
activities,
aureus.
A
five-fold
reduction
planktonic
four-fold
populations
were
observed
after
treatment
hexosomes.
The
nanoparticles
had
bacteriostatic
effect
epidermidis
cells
but
no
activity
was
detected.
discuss
findings
terms
nanoparticle-bacterial
interactions,
plausible
alterations
phospholipid
membrane
composition,
penetration
DHA
into
membranes,
leading
changes
their
structural
biophysical
properties.
implications
future
delivery
alone
or
combination
other
agents
discussed,
novel
strategies
infections,
including
biofilm-associated
infections.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 25, 2024
Hydrogels
are
well-suited
for
biomedical
applications
due
to
their
numerous
advantages,
such
as
excellent
bioactivity,
versatile
physical
and
chemical
properties,
effective
drug
delivery
capabilities.
Recently,
hydrogel
coatings
have
developed
functionalize
bone
implants
which
biologically
inert
cannot
withstand
the
complex
tissue
repair
microenvironment.
These
shown
promise
in
addressing
unique
pressing
medical
needs.
This
review
begins
with
major
functionalized
performance
interfacial
bonding
strategy
of
coatings,
a
focus
on
novel
external
field
response
properties
hydrogel.
Recent
advances
fabrication
strategies
use
treatment
pathologic
regeneration
highlighted.
Finally,
challenges
emerging
trends
evolution
application
physiological
environment-responsive
electric
field-responsive
discussed.
Journal of Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
The
current
antibacterial
strategies
focus
on
antibiotic
therapy
and
extensive
hygienic
measures
during
orthopedic
surgery.
However,
potential
development
of
implant-associated
infections
remains
a
persistent
clinical
challenge.
There
is,
therefore,
growing
interest
in
introducing
innovative
safe
for
preventing
combating
biofilm
implants.
Antibacterial
coatings,
particularly,
are
attractive
local
delivery
agents.
We
aim
this
proof-of-concept
study
at
novel
translatable
implant
coating
approach,
focusing
directed
assembly
inverse
non-lamellar
lyotropic
liquid
crystalline
(LLC)
nanostructures
implants
prevention
initial
bacterial
attachment
formation
through
the
widely
used
cationic
colistin
(COL).
On
exposure
dry
lipid
films
deposited
model
to
aqueous
solutions
COL
prepared
different
concentrations,
set
LLC
coatings
based
commercial
distilled
monoglyceride
product
(or
glycerol
monooleate)
were
produced.
In
addition
small-angle
X-ray
scattering
(SAXS)
characterization
investigations,
vitro
studies
conducted
evaluating
antibiofilm
properties
against
Gram-negative
bacteria
Pseudomonas
aeruginosa.
SAXS
analysis
indicated
that
all
samples
bicontinuous
cubic
Pn3m
phases.
Significant
COL's
activity
efficient
protection
adhesion
demonstrated
with
surface
produced
by
using
containing
concentrations
50
500
µg/mL.
serum,
detected
structural
alterations
changes
also
discussed.
This
highlights
implications
self-assemblies
designing
nanostructural
implants,
which
can
prevent
ACS Polymers Au,
Journal Year:
2024,
Volume and Issue:
4(6), P. 498 - 511
Published: Aug. 22, 2024
Antibacterial
coatings
on
model
silicon
wafers
and
implants,
based
chitosan
(CHI),
poly(acrylic
acid)
(PAA),
the
antibacterial
agent
chlorhexidine
digluconate
(CHX),
were
obtained
using
a
layer-by-layer
assembly
method.
The
surface
roughness
2D
3D
images
of
surfaces
CHI/PAA/CHX
from
different
pH
assemblies
investigated
by
atomic
force
microscopy,
revealing
that
6
enabled
optimal
inclusion
CHX
in
multilayer
film.
structure
elemental
composition
before
after
implementation
into
coating
via
scanning
electron
microscopy
energy-dispersive
X-ray
spectroscopy.
films
exhibited
antimicrobial
efficacy
against
Staphylococcus
aureus
epidermidis.
effects
concentration
duration
contact
with
bacterial
activity
investigated,
quantitative
release
coated
implants
phosphate
buffer
was
determined
as
function
incubation
time.
biocompatibility
PAA/CHI/CHX
human
mononuclear
cells
(HMNCs)
quantified
an
MTT
assay.
HMNCs
demonstrated
high
viability
eluted
solutions
(0.025%)
(0.0125%),
while
extract
(0.05%)
induced
slight
cytotoxicity.
