Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
Postoperative
infections
in
artificial
joints
provide
considerable
difficulties
the
field
of
orthopedics,
especially
after
joint
replacement
procedures.
These
rank
among
most
severe
postoperative
consequences,
frequently
leading
to
treatment
ineffectiveness
and
reduced
quality
life
for
surgery
patients.
Consequently,
it
is
crucial
acquire
knowledge
about
worldwide
research
trends
this
area
order
educate
clinical
practices
improve
therapeutic
techniques.
This
work
exploits
bibliometric
analysis
investigate
present
state,
developing
patterns,
main
areas
focus
on
infection.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 25, 2024
Hydrogels
are
well-suited
for
biomedical
applications
due
to
their
numerous
advantages,
such
as
excellent
bioactivity,
versatile
physical
and
chemical
properties,
effective
drug
delivery
capabilities.
Recently,
hydrogel
coatings
have
developed
functionalize
bone
implants
which
biologically
inert
cannot
withstand
the
complex
tissue
repair
microenvironment.
These
shown
promise
in
addressing
unique
pressing
medical
needs.
This
review
begins
with
major
functionalized
performance
interfacial
bonding
strategy
of
coatings,
a
focus
on
novel
external
field
response
properties
hydrogel.
Recent
advances
fabrication
strategies
use
treatment
pathologic
regeneration
highlighted.
Finally,
challenges
emerging
trends
evolution
application
physiological
environment-responsive
electric
field-responsive
discussed.
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(10), P. 5726 - 5737
Published: May 15, 2024
Catheter-related
infections
are
some
of
the
most
common
acquired
in
hospitals,
and
designing
functional
coatings
on
surface
medical
catheters
to
limit
bacterial
colonization
biofilm
formation
can
be
effective
avoiding
infections.
In
this
study,
a
composite
coating
(PU-PDA-Ag-PDA-PHMG)
with
simultaneous
antifouling,
contact-active,
release-kill
properties
was
prepared
polyurethane
(PU)
surfaces
using
polydopamine,
Ag
nanoparticles,
polyhexamethylene
guanidine.
This
systematically
evaluated
by
studying
its
long-term
hydrophilicity,
antibacterial
property,
antibiofilm
silver
release
rate,
mechanical
biocompatibility.
The
results
scanning
electron
microscopy,
atomic
force
Fourier
transform
infrared
spectrometry,
X-ray
photoelectron
spectroscopy
showed
that
PU-PDA-Ag-PDA-PHMG
multimechanism
successfully
PU
surface.
Relative
value
97.62°
for
unmodified
substrate,
water
contact
angle
increased
from
49.73°
61.68°
after
28
days
deionized
immersion,
indicating
excellent
hydrophilic
properties.
Also,
reduces
protein
adhesion
58.67%.
After
immersion
PBS
solution,
rates
against
Staphylococcus
aureus
Escherichia
coli
still
reached
97.67%
99.5%,
respectively,
broad-spectrum
property
significantly
improved
compared
single-mechanism
coating,
almost
free
any
bacteria.
total
amount
ions
released
about
16.95%
PU-PDA-Ag
within
14
days,
which
proved
could
reduce
rate
ions.
preparation
process
also
did
not
change
original
biocompatibility
(cytotoxicity
level
1).
conclusion,
developed
study
has
great
potential
reducing
catheter-associated
Journal of Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
669, P. 537 - 551
Published: April 27, 2024
Infectious
diseases,
particularly
those
associated
with
biofilms,
are
challenging
to
treat
due
an
increased
tolerance
commonly
used
antibiotics.
This
underscores
the
urgent
need
for
innovative
antimicrobial
strategies.
Here,
we
present
alternative
simple-by-design
approach
focusing
on
development
of
biocompatible
and
antibiotic-free
nanocarriers
from
docosahexaenoic
acid
(DHA)
that
has
potential
combat
microbial
infections
phosphatidylglycerol
(DOPG),
which
is
attractive
use
as
a
prominent
amphiphilic
component
Gram-positive
bacterial
cell
membranes.
We
assessed
anti-bacterial
anti-biofilm
activities
these
nanoformulations
(hexosomes
vesicles)
against
S.
aureus
epidermidis,
most
common
causes
catheters
medical
devices
by
different
methods
(including
resazurin
assay,
time-kill
confocal
laser
scanning
microscopy
in
vitro
catheter
biofilm
model).
In
DHA-concentration-dependent
manner,
nano-self-assemblies
demonstrated
strong
activities,
aureus.
A
five-fold
reduction
planktonic
four-fold
populations
were
observed
after
treatment
hexosomes.
The
nanoparticles
had
bacteriostatic
effect
epidermidis
cells
but
no
activity
was
detected.
discuss
findings
terms
nanoparticle-bacterial
interactions,
plausible
alterations
phospholipid
membrane
composition,
penetration
DHA
into
membranes,
leading
changes
their
structural
biophysical
properties.
implications
future
delivery
alone
or
combination
other
agents
discussed,
novel
strategies
infections,
including
biofilm-associated
infections.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 29, 2024
In
this
study,
zeolitic
imidazolate
framework
8
(ZIF-8)
was
coated
on
porous
Ti6Al4V
scaffolds,
either
bare
or
previously
modified
using
hydroxyapatite
(HA)
HA
and
gelatin
(HAgel),
via
a
growing
single-step
method
in
aqueous
media
two
contact
times
at
6
h
24
h.
The
scaffolds
termed
ZIF-8@Ti,
ZIF-8@HA/Ti,
ZIF-8@HAgel/Ti
were
characterized
scanning
electron
microscopy
(SEM),
powder
X-ray
diffraction
(PXRD),
attenuated
total
reflectance-Fourier
transform
infrared
(ATR-FTIR),
molecular
plasma-atomic
emission
spectroscopy
(MP-AES).
order
to
assess
the
cell
proliferation
rate,
cytocompatibility
of
evaluated
primary
osteoblasts
(hOBs)
alamarBlue
assay,
while
osteoconductivity
analyzed
hOBs
real-time
approach,
evaluating
expression
secreted
phosphoprotein
1
(SPP1).
Osteopontin,
which
is
protein
encoded
by
gene,
represents
major
non-collagenous
bone
that
binds
tightly
HA.
shown
be
non-cytotoxic
based
hOB
all
time
points
analysis
(24
72
h).
cultures,
induced
upregulation
SPP1
with
different
fold
changes.
Some
selected
assayed
vitro
for
their
antibacterial
potential
against
Staphylococcus
epidermidis
;
ZIF-8
crystals,
regardless
presence
gelatin,
strongly
inhibited
bacterial
adhesion
materials
reduced
culture
medium,
demonstrating
suitable
release
bioactive
form.
These
experiments
suggest
innovative
tested
herein,
provide
good
microenvironment
adhesion,
viability,
osteoconduction
effective
prevention
S.
adhesion.
Journal of Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
The
current
antibacterial
strategies
focus
on
antibiotic
therapy
and
extensive
hygienic
measures
during
orthopedic
surgery.
However,
potential
development
of
implant-associated
infections
remains
a
persistent
clinical
challenge.
There
is,
therefore,
growing
interest
in
introducing
innovative
safe
for
preventing
combating
biofilm
implants.
Antibacterial
coatings,
particularly,
are
attractive
local
delivery
agents.
We
aim
this
proof-of-concept
study
at
novel
translatable
implant
coating
approach,
focusing
directed
assembly
inverse
non-lamellar
lyotropic
liquid
crystalline
(LLC)
nanostructures
implants
prevention
initial
bacterial
attachment
formation
through
the
widely
used
cationic
colistin
(COL).
On
exposure
dry
lipid
films
deposited
model
to
aqueous
solutions
COL
prepared
different
concentrations,
set
LLC
coatings
based
commercial
distilled
monoglyceride
product
(or
glycerol
monooleate)
were
produced.
In
addition
small-angle
X-ray
scattering
(SAXS)
characterization
investigations,
vitro
studies
conducted
evaluating
antibiofilm
properties
against
Gram-negative
bacteria
Pseudomonas
aeruginosa.
SAXS
analysis
indicated
that
all
samples
bicontinuous
cubic
Pn3m
phases.
Significant
COL's
activity
efficient
protection
adhesion
demonstrated
with
surface
produced
by
using
containing
concentrations
50
500
µg/mL.
serum,
detected
structural
alterations
changes
also
discussed.
This
highlights
implications
self-assemblies
designing
nanostructural
implants,
which
can
prevent
