Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 27, 2023
With
increased
diabetes
incidence,
diabetic
wound
healing
is
one
of
the
most
common
complications
and
characterized
by
easy
infection,
chronic
inflammation,
reduced
vascularization.
To
address
these
issues,
biomaterials
with
multifunctional
antibacterial,
immunomodulatory,
angiogenic
properties
must
be
developed
to
improve
overall
for
patients.
In
our
study,
we
prepared
porous
poly
(L-lactic
acid)
(PLA)
nanofiber
membranes
using
electrospinning
solvent
evaporation
methods.
Then,
sulfated
chitosan
(SCS)
combined
polydopamine-gentamicin
(PDA-GS)
was
stepwise
modified
onto
PLA
membrane
surfaces.
Controlled
GS
release
facilitated
via
dopamine
self-polymerization
prevent
early
stage
infection.
PDA
also
applied
suppress
inflammation.
vitro
cell
tests
results
showed
that
PLA/SCS/PDA-GS
immuomodulated
macrophage
toward
M2
phenotype
endogenous
vascular
endothelial
growth
factor
secretion
induce
Moreover,
SCS-contained
good
potential
in
enhancing
trans-differentiation
fibroblasts,
thereby
improving
processes.
Furthermore,
antibacterial
studies
against
Staphylococcus
aureus
indicated
effective
membranes.
summary,
novel
possessing
enhanced
anti-inflammatory,
demonstrate
promising
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Dec. 20, 2023
The
skeleton
is
a
highly
innervated
organ
in
which
nerve
fibers
interact
with
various
skeletal
cells.
Peripheral
endings
release
neurogenic
factors
and
sense
signals,
mediate
bone
metabolism
pain.
In
recent
years,
tissue
engineering
has
increasingly
focused
on
the
effects
of
nervous
system
regeneration.
Simultaneous
regeneration
nerves
through
use
materials
or
by
enhancement
endogenous
repair
signals
been
proven
to
promote
functional
Additionally,
emerging
information
mechanisms
interoception
central
regulation
homeostasis
provide
an
opportunity
for
advancing
biomaterials.
However,
comprehensive
reviews
this
topic
are
lacking.
Therefore,
review
provides
overview
relationship
between
regeneration,
focusing
applications.
We
discuss
novel
regulatory
explore
innovative
approaches
based
nerve-bone
interactions
Finally,
challenges
future
prospects
field
briefly
discussed.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(21)
Published: May 10, 2023
Abstract
Antibacterial
dynamic
therapy
(ADT)
triggered
by
reactive
oxygen
species
(ROS)
is
promising
for
diabetic
infectious
disease
treatment.
However,
the
limited
local
O
2
/H
production
and
post‐treatment
inflammation
remain
long‐standing
issues.
To
address
these
challenges,
a
novel
H
‐evolving
bio‐heterojunction
enzyme
(Bio‐HJzyme)
consisting
of
graphite‐phase
carbon
nitride/copper
sulfide
(CN/Cu
2−
x
S)
heterojunction
glucose
oxidase
(GO
)
created.
The
Bio‐HJzyme
offers
glutathione
peroxidase
(GP
),
(POD),
catalase
(CAT)
mimetic
activities;
provides
anti‐pathogen
properties
via
programmed
light
activation;
effectively
promotes
wound
healing.
Specifically,
its
GP
‐mimetic
activity
presence
GO
significantly
enhance
yield
,
which
can
be
catalyzed
through
POD‐mimetic
to
produce
highly
germicidal
•OH.
also
assisted
CAT‐mimetic
activity.
products
then
into
•OH
•O
−
under
NIR
irradiation,
giving
enhanced
ADT.
Further,
CN
split
water
form
solar
light,
dramatically
suppresses
caused
excessive
ROS.
In
vivo
evaluation
confirms
that
regeneration
skin
killing
bacteria,
enhancing
angiogenesis,
promoting
bed
epithelialization,
reinforcing
anti‐inflammatory
responses;
hence,
providing
revolutionary
approach
wounds
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
Physical
cues
like
morphology,
light,
electric
signal,
mechanic
magnetic
and
heat
can
be
used
as
alternative
regulators
for
expensive
but
short‐acting
growth
factors
in
bone
tissue
engineering
to
promote
osteogenic
differentiation
regeneration.
As
physical
stimulation
applied
directly
the
cannot
focused
on
defect
area
regulate
cell
behaviors
fate
situ,
this
limits
efficiency
of
precise
Biomaterials‐mediated
situ
cues,
an
effective
strategy
combining
synergistic
effect
materials
themselves,
are
put
forward
studied
widely
repair
efficiently
precisely.
Different
types
provide
different
choices
better
satisfy
requirements
targeted
repair.
In
review,
recent
research
about
biomaterials‐mediated
accelerating
osteogenesis
vitro
promoting
formation
vivo
is
introduced.
Meanwhile,
corresponding
possible
mechanisms
various
regulating
responses
also
discussed.
This
review
provides
useful
enlightening
guidance
utilization
intrinsically
properties
functional
achieve
efficient
regeneration,
leading
design
construction
smart
biomaterials
practical
applications,
eventually
clinical
translation.
Animal Models and Experimental Medicine,
Journal Year:
2023,
Volume and Issue:
6(2), P. 120 - 130
Published: March 1, 2023
Abstract
Understanding
the
bioelectrical
properties
of
bone
tissue
is
key
to
developing
new
treatment
strategies
for
diseases
and
injuries,
as
well
improving
design
fabrication
scaffold
implants
engineering.
The
can
be
attributed
interaction
its
various
cell
lineages
(osteocyte,
osteoblast
osteoclast)
with
surrounding
extracellular
matrix,
in
presence
biomechanical
stimuli
arising
from
routine
physical
activities;
best
described
a
combination
overlap
dielectric,
piezoelectric,
pyroelectric
ferroelectric
properties,
together
streaming
potential
electro‐osmosis.
There
close
interdependence
electroactive
electrosensitive
components
tissue,
including
membrane
potential,
voltage‐gated
ion
channels,
intracellular
signaling
pathways,
surface
receptors,
matrix
such
collagen,
hydroxyapatite,
proteoglycans
glycosaminoglycans.
It
remarkably
complex
web
interactive
cross‐talk
between
organic
non‐organic
that
define
electrophysiological
which
turn
exerts
profound
influence
on
metabolism,
homeostasis
regeneration
health
disease.
This
has
spurred
increasing
interest
application
scaffolds
engineering,
recapitulate
natural
microenvironment
healthy
facilitate
defect
repair.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 27, 2023
With
increased
diabetes
incidence,
diabetic
wound
healing
is
one
of
the
most
common
complications
and
characterized
by
easy
infection,
chronic
inflammation,
reduced
vascularization.
To
address
these
issues,
biomaterials
with
multifunctional
antibacterial,
immunomodulatory,
angiogenic
properties
must
be
developed
to
improve
overall
for
patients.
In
our
study,
we
prepared
porous
poly
(L-lactic
acid)
(PLA)
nanofiber
membranes
using
electrospinning
solvent
evaporation
methods.
Then,
sulfated
chitosan
(SCS)
combined
polydopamine-gentamicin
(PDA-GS)
was
stepwise
modified
onto
PLA
membrane
surfaces.
Controlled
GS
release
facilitated
via
dopamine
self-polymerization
prevent
early
stage
infection.
PDA
also
applied
suppress
inflammation.
vitro
cell
tests
results
showed
that
PLA/SCS/PDA-GS
immuomodulated
macrophage
toward
M2
phenotype
endogenous
vascular
endothelial
growth
factor
secretion
induce
Moreover,
SCS-contained
good
potential
in
enhancing
trans-differentiation
fibroblasts,
thereby
improving
processes.
Furthermore,
antibacterial
studies
against
Staphylococcus
aureus
indicated
effective
membranes.
summary,
novel
possessing
enhanced
anti-inflammatory,
demonstrate
promising
