3D printing in materials manufacturing industry: A realm of Industry 4.0

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19689 - e19689

Published: Sept. 1, 2023

Additive manufacturing (AM), also known as 3D printing, is a new trend showing promising progress over time in the era of Industry 4.0. So far, various research has been done for increasing reliability and productivity printing process. In this regard, reviewing existing concepts forwarding novel directions are important. This paper reviews summarizes process flow, technologies, configurations, monitoring AM. It started with general AM followed by definitions working principles technologies possible such traditional robot-assisted Then, defect detection, fault diagnosis, open-loop closed-loop control systems discussed. noted that introducing robots into assisting mechanism increases Moreover, integrating machine learning conventional algorithms ensures AM, strategy. Lastly, addresses challenges future trends.

Language: Английский

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Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 1982 - 2035

Published: Jan. 1, 2024

Many human tissues exhibit a highly oriented architecture that confers them with distinct mechanical properties, enabling adaptation to diverse and challenging environments. Hydrogels, their water-rich "soft wet" structure, have emerged as promising biomimetic materials in tissue engineering for repairing replacing damaged organs. Highly hydrogels can especially emulate the structural orientation found tissue, exhibiting unique physiological functions properties absent traditional homogeneous isotropic hydrogels. The design preparation of involve strategies like including nanofillers, polymer-chain networks, void channels, microfabricated structures. Understanding specific mechanism action how these affect cell behavior biological applications such cornea, skin, skeletal muscle, tendon, ligament, cartilage, bone, blood vessels, heart, etc., requires further exploration generalization. Therefore, this review aims fill gap by focusing on strategy application field engineering. Furthermore, we provide detailed discussion various organs mechanisms through which structures influence behavior.

Language: Английский

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Bioprinting Macroporous Hydrogel with Aqueous Two‐Phase Emulsion‐Based Bioink: In Vitro Mineralization and Differentiation Empowered by Phosphorylated Cellulose Nanofibrils

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: March 14, 2024

Abstract Aqueous two‐phase emulsion (ATPE)‐based bioinks, a creative innovation for bioprinting, enable the fabrication of complex 3D cell‐laden hydrogels with macroporous structure, which promote cellular activities within scaffold. However, these bioinks intrinsically lack stability and specific biofunctionality, potentially limiting their application targeted tissue engineering. This study proposes new perspective by introducing less than 0.1% phosphorylated cellulose nanofibrils (pCNF), 1D nanofibril top‐down produced from natural biomasses, into dextran/methacrylated gelatin (GelMA)‐based ATPE system extrusion‐based bioprinting preosteoblastic cells, aiming to fabricate osteogenic differentiation potential. The pCNF that is selectively partitioned in GelMA phase can not only improve alter rheological behaviors ATPE‐based bioink, but also enhance damping capacity mineralization ability crosslinked hydrogels. Furthermore, demonstrate increased cell activity higher viability post‐printing, along alkaline phosphatase osteoblastic gene expression. Importantly, organized interfaces hydrogel facilitate formation macroscopic biomineralized nodules vitro. incorporation multifunctional significantly boosts physiochemical biological performance macropore‐forming transforming them suitable platform engineering vitro bone models.

Language: Английский

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Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review

Annals of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 52(5), P. 1184 - 1194

Published: Feb. 28, 2024

Language: Английский

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Exploring the Potentials of Chitin and Chitosan‐Based Bioinks for 3D‐Printing of Flexible Electronics: The Future of Sustainable Bioelectronics

Small Methods, Journal Year: 2024, Volume and Issue: 8(9)

Published: Feb. 25, 2024

Chitin and chitosan-based bioink for 3D-printed flexible electronics have tremendous potential innovation in healthcare, agriculture, the environment, industry. This biomaterial is suitable 3D printing because it highly stretchable, super-flexible, affordable, ultrathin, lightweight. Owing to its ease of use, on-demand manufacturing, accurate regulated deposition, versatility with soft functional materials, has revolutionized free-form construction end-user customization. study examined employing chitin bioinks build electronic devices optimize formulation, parameters, postprocessing processes improve mechanical electrical properties. The exploration bioelectronics will open new avenues materials numerous industrial applications.

Language: Английский

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3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 359 - 359

Published: March 4, 2024

The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, printability prepared was determined. with 2.5% w/v high molecular-weight chitosan (CS), 2% gelatin (Gel), 10% w/w (Ex) presented best printability, producing smooth uniform scaffolds. It proved that CS/Gel/Ex stabilized by hydrogen bonds remained amorphous dispersion structures (confirmed ATR-FTIR XRPD). Due amorphization active substance, significant increase release baicalin vitro observed. demonstrated there initial burst continuous profile (n = 3). Higuchi kinetic most likely kinetic. second fit, Korsmeyer–Peppas kinetics model, showed coupled diffusion ingredient hydrated matrix polymer relaxation regulated release, n values ranging from 0.45 0.89. properties scaffolds assessed ability inhibit activity hyaluronidase enzyme. Activity IC50 63.57 ± 4.98 mg hydrogel/mL 6). Cytotoxicity tests biocompatibility material. After 24 h exposure 2.5CS/2Gel/10Ex scaffold, fibroblasts migrated toward scratch, closed “wound” 97.1%, significantly accelerated wound healing process. results render CS/Gel/extract potential candidates treating

Language: Английский

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: April 17, 2024

Abstract Scaffold‐based tissue engineering provides an efficient approach for repairing uterine defects and restoring fertility. In the current study, a novel trilayer scaffold with high similarity to in structure was designed fabricated via 4D printing, electrospinning 3D bioprinting regeneration. Highly stretchable poly( l ‐lactide‐ co ‐trimethylene carbonate) (PLLA‐ ‐TMC, “PTMC” short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made printing. To improve biocompatibility, porous poly(lactic acid‐ ‐glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated polydopamine (PDA) particles produced on PTMC/TPU electrospinning. Importantly, estradiol (E2) encapsulated PDA particles. The bilayer thus could provide controlled sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) mixed gelatin (GelMA)‐based inks formulated bioinks used fabricate cell‐laden hydrogel layer bioprinting, forming ultimately biomimicking formed exhibited shape morphing ability by transforming from planar tubular structures when immersed culture medium at 37°C. under development would new insights

Language: Английский

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Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

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Porous biomaterial scaffolds for skeletal muscle tissue engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 3, 2023

Volumetric muscle loss is a traumatic injury which overwhelms the innate repair mechanisms of skeletal and results in significant functionality. Tissue engineering seeks to regenerate these injuries through implantation biomaterial scaffolds encourage endogenous tissue formation restore mechanical function. Many types are currently being researched for this purpose. Scaffolds typically made from either natural, synthetic, or conductive polymers, any combination therein. A major criterion use their porosity, essential myoblast infiltration myofiber ingrowth. In review, we summarize various methods fabricating porous regeneration, as well materials used make scaffolds. We provide guidelines fabrication based on functional requirements tissue, discuss general state field engineering.

Language: Английский

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Mathematical Modelling of Fused Deposition Modeling (FDM) 3D Printing of Poly Vinyl Alcohol Parts through Statistical Design of Experiments Approach

Mathematics, Journal Year: 2023, Volume and Issue: 11(13), P. 3022 - 3022

Published: July 7, 2023

This paper explores the 3D printing of poly vinyl alcohol (PVA) using fused deposition modeling (FDM) process by conducting statistical and optimization. study focuses on varying infill percentage (10–50%) patterns (Cubic, Gyroid, tri-hexagon triangle, Grid) as input parameters for response surface methodology (DOE) while measuring modulus, elongation at break, weight experimental responses. To determine optimal parameters, a regression equation analysis was conducted to identify most significant parameters. The results indicate that both significantly impact output Design Expert software utilized create residual plots, interaction between two shows increasing (IP) leads heavier samples, do not affect parts due close structures. On contrary, discrepancy predicted actual responses samples is below 15%. level error deemed acceptable DOE experiments.

Language: Английский

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