Harnessing Bacterial Extracellular Vesicle Immune Effects for Cancer Therapy DOI Creative Commons
İrem Karaman, Asmita Pathak, Defne Bayık

et al.

Pathogens and Immunity, Journal Year: 2024, Volume and Issue: 9(1), P. 56 - 90

Published: April 23, 2024

There are a growing number of studies linking the composition human microbiome to disease states and treatment responses, especially in context cancer. This has raised significant interest developing microbes microbial products as cancer immunotherapeutics that mimic or recapitulate beneficial effects host-microbe interactions. Bacterial extracellular vesicles (bEVs) nano-sized, membrane-bound particles secreted by essentially all bacteria species contain diverse bioactive cargo producing cell. They have fundamental role facilitating interactions among cells same species, different even with multicellular host organisms colonization (microbiome) infection. The interaction bEVs immune system been studied extensively infection suggests bEV depend largely on species. thus provide functional diversity, while also being nonreplicative, having inherent cell-targeting qualities, potentially overcoming natural barriers. These characteristics make them highly appealing for development immunotherapeutics. Both natively engineered now investigated their application immunotherapeutics, vaccines, drug delivery vehicles, combinations above, promising early results. both intrinsic immunomodulatory properties ability be modified could harnessed next-generation microbe-inspired therapies. Nonetheless, there remain major outstanding questions regarding how observed preclinical effectiveness will translate from murine models primates, humans particular. Moreover, research into pharmacology, toxicology, mass manufacturing this potential novel therapeutic platform is still at stages. In review, we highlight breadth cells, focusing immunologic main mechanism action currently development. We review literature ongoing efforts develop variety bacterial therapy finally discuss overcome challenges clinical translation.

Language: Английский

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications DOI Creative Commons
Meng Sun,

Jiani Yang,

Yueyun Fan

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(32)

Published: Sept. 25, 2023

Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics artificially acquired advantages. However, limited targeting ability, insufficient production yield, low drug-loading capability simplex EVs greatly hindered development clinical translation. Therefore, establishment multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability flexibility has become key expanding practical application EVs. This timely review summarizes current progress HMNVs biomedical applications. Different preparation strategies including physical, chemical, chimera approaches are first discussed. then individually describes diverse types based on homologous or heterologous cell substances, a fusion liposome, well bacterial membrane. Subsequently, specific emphasis is placed highlight applications toward various diseases representative examples. Finally, ongoing challenges prospects currently developed translational briefly presented. will not only stimulate broad interest among researchers from disciplines but also provide valuable insights promising nanoplatforms precision medicine.

Language: Английский

Citations

46
Bioengineered Bacterial Membrane Vesicles with Multifunctional Nanoparticles as a Versatile Platform for Cancer Immunotherapy DOI

Xin Zheng Liu,

Zhi Juan Wen,

Yun Meng Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(3), P. 3744 - 3759

Published: Jan. 11, 2023

Inducing immunogenic cell death (ICD) is a critical strategy for enhancing cancer immunotherapy. However, inefficient and risky ICD inducers along with tumor hypoxia microenvironment seriously limit the immunotherapy efficacy. Non-specific delivery also responsible this inefficiency. In work, we report drug-free bacteria-derived outer membrane vesicle (OMV)-functionalized Fe3O4-MnO2 (FMO) nanoplatform that realized neutrophil-mediated targeted photothermally enhanced system, modification of OMVs derived from Escherichia coli accumulation FMO NPs at tissue through delivery. The underwent reactive decomposition in site, generating manganese iron ions induced O2 regulated environment. Moreover, are rich pathogen-associated pattern molecules can overcome immunosuppressive effectively activate immune cells, thereby specific responses. Photothermal therapy (PTT) caused by MnO2 Fe3O4 not only indirectly stimulate systemic immunity directly destroying cells but promote enrichment neutrophil-equipped nanoparticles inflammatory response site. Finally, proposed multi-modal treatment system capability effective to prevent growth recurrence.

Language: Английский

Citations

45
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

32
Recent advancements in nanoconstructs for the theranostics applications for triple negative breast cancer DOI Creative Commons
Ashutosh Gupta, Kumar Nishchaya, Moumita Saha

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105401 - 105401

Published: Jan. 25, 2024

Cancer is a major public health concern worldwide; it the second-highest cause of death in United States. According to projections cancer incidence and mortality rates throughout world for year 2023, triple-negative breast (TNBC) expected be leading related among women worldwide. Traditional strategies treatment TNBC have many drawbacks, such as drug resistance, toxicity etc. Discovering novel delivery techniques researching innovative, efficient methods important. This review discusses types subtypes TNBC. The problems associated with standard therapies, mechanism resistance highlights need develop therapeutic strategies. It provides information on relative prevalence severity cancer. Several approaches viz. targeted therapy, gene bacterial-mediated nanomedicine, immune checkpoint inhibitors, theranostic, radiotherapy, chemotherapy, immunotherapy, herbal AI-based TNBC, are discussed detail. Additionally, diagnostic techniques, including imaging biopsy, expression profiling, mammography, magnetic resonance imaging, ultrasound, computed tomography scan, positron emission immunohistochemistry, been effective treatment. in-depth analysis innovative individualized care serve patients better.

Language: Английский

Citations

21
Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine DOI Creative Commons
Jiming Guo, Zhijie Huang, Qinjing Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 3, 2025

Language: Английский

Citations

7
Innovative Applications of Bacteria and Their Derivatives in Targeted Tumor Therapy DOI

Denghui Zhu,

Wei Pan,

Heqi Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Despite significant progress in cancer treatment, traditional therapies still face considerable challenges, including poor targeting, severe toxic side effects, and the development of resistance. Recent advances biotechnology have revealed potential bacteria their derivatives as drug delivery systems for tumor therapy by leveraging biological properties. Engineered bacteria, Escherichia coli, Salmonella, Listeria monocytogenes, along with derivatives─outer membrane vesicles (OMVs), bacterial ghosts (BGs), spores (BSPs)─can be loaded a variety antitumor agents, enabling precise targeting sustained release within microenvironment (TME). These possess intrinsic properties that stimulate immune system, enhancing both innate adaptive responses to further amplify therapeutic effects. The ability naturally accumulate hypoxic regions versatility genetic modifications allow tailored strategies synergistically enhance effectiveness chemotherapy, immunotherapy, targeted therapies. This review comprehensively examines fundamental principles therapy, focusing on employed engineering, loading, use therapy. It also discusses challenges faced optimizing systems, such safety concerns, unintended responses, scalability clinical applications. By exploring these aspects, this provides theoretical framework improving bacterial-based contributing more effective personalized treatments.

Language: Английский

Citations

5
Nanomedicine‐Enabled/Augmented Cell Pyroptosis for Efficient Tumor Nanotherapy DOI
Zheng Zhang, Yajun Zhou, Shuangshuang Zhao

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(35)

Published: Oct. 20, 2022

The terrible morbidity and mortality of malignant tumors urgently require innovative therapeutics, especially for apoptosis-resistant tumors. Pyroptosis, a pro-inflammatory form programmed cell death (PCD), is featured with pore formation in plasma membrane, swelling giant bubbles, leakage cytoplasmic cytokines, which can remodel the tumor immune microenvironment by stimulating "cold" to be an immunogenic "hot" microenvironment, consequently augment therapeutic efficiency Benefiting from current advances nanotechnology, nanomedicine extensively applied potentiate, enable, pyroptosis enhancing cancer-therapeutic efficacy specificity. This review provides concentrated summary discussion most recent progress achieved this emerging field, highlighting nanomedicine-enabled/augmented specific strategy favoring construction next-generation nanomedicines efficiently induce PCD. It highly expected that further clinical translation accelerated inducing pyroptotic based on bioactive nanomedicines.

Language: Английский

Citations

60
Macrophage-reprogramming upconverting nanoparticles for enhanced TAM-mediated antitumor therapy of hypoxic breast cancer DOI

Johyun Yoon,

Xuan Thien Le, Juho Kim

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 482 - 495

Published: July 12, 2023

Language: Английский

Citations

28
Bacterial extracellular vesicles and their interplay with the immune system DOI
Étienne Doré, Éric Boilard

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 247, P. 108443 - 108443

Published: May 18, 2023

Language: Английский

Citations

27
Engineering Versatile Bacteria‐Derived Outer Membrane Vesicles: An Adaptable Platform for Advancing Cancer Immunotherapy DOI Creative Commons

Ziheng Luo,

Cheng Xiang, Bin Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 1, 2024

In recent years, cancer immunotherapy has undergone a transformative shift toward personalized and targeted therapeutic strategies. Bacteria-derived outer membrane vesicles (OMVs) have emerged as promising adaptable platform for due to their unique properties, including natural immunogenicity the ability be engineered specific purposes. this review, comprehensive overview is provided of state-of-the-art techniques methodologies employed in engineering versatile OMVs immunotherapy. Beginning by exploring biogenesis composition OMVs, unveiling intrinsic immunogenic properties appeal. Subsequently, innovative approaches engineer are delved into, ranging from genetic parent bacteria incorporation functional molecules. The importance rational design strategies highlighted enhance specificity allowing tailoring diverse types. Furthermore, insights into clinical studies potential challenges utilizing vaccines or adjuvants also provided, offering assessment current landscape future prospects. Overall, review provides valuable researchers involved rapidly evolving field immunotherapy, roadmap harnessing full treatment.

Language: Английский

Citations

13