International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5545 - 5579
Опубликована: Июнь 1, 2024
Pyroptosis,
a
pro-inflammatory
and
lytic
programmed
cell
death
pathway,
possesses
great
potential
for
antitumor
immunotherapy.
By
releasing
cellular
contents
large
number
of
factors,
tumor
pyroptosis
can
promote
dendritic
maturation,
increase
the
intratumoral
infiltration
cytotoxic
T
cells
natural
killer
cells,
reduce
immunosuppressive
within
tumor.
However,
efficient
induction
prevention
damage
to
normal
tissues
or
is
an
urgent
concern
be
addressed.
Recently,
wide
variety
nanoplatforms
have
been
designed
precisely
trigger
activate
immune
responses.
This
review
provides
update
on
progress
in
nanotechnology
enhancing
pyroptosis-based
Nanomaterials
shown
advantages
triggering
by
delivering
initiators
tumors,
increasing
oxidative
stress
inducing
intracellular
osmotic
pressure
changes
ion
imbalances.
In
addition,
challenges
future
perspectives
this
field
are
proposed
advance
clinical
translation
pyroptosis-inducing
nanomedicines.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(3), С. 3744 - 3759
Опубликована: Янв. 11, 2023
Inducing
immunogenic
cell
death
(ICD)
is
a
critical
strategy
for
enhancing
cancer
immunotherapy.
However,
inefficient
and
risky
ICD
inducers
along
with
tumor
hypoxia
microenvironment
seriously
limit
the
immunotherapy
efficacy.
Non-specific
delivery
also
responsible
this
inefficiency.
In
work,
we
report
drug-free
bacteria-derived
outer
membrane
vesicle
(OMV)-functionalized
Fe3O4-MnO2
(FMO)
nanoplatform
that
realized
neutrophil-mediated
targeted
photothermally
enhanced
system,
modification
of
OMVs
derived
from
Escherichia
coli
accumulation
FMO
NPs
at
tissue
through
delivery.
The
underwent
reactive
decomposition
in
site,
generating
manganese
iron
ions
induced
O2
regulated
environment.
Moreover,
are
rich
pathogen-associated
pattern
molecules
can
overcome
immunosuppressive
effectively
activate
immune
cells,
thereby
specific
responses.
Photothermal
therapy
(PTT)
caused
by
MnO2
Fe3O4
not
only
indirectly
stimulate
systemic
immunity
directly
destroying
cells
but
promote
enrichment
neutrophil-equipped
nanoparticles
inflammatory
response
site.
Finally,
proposed
multi-modal
treatment
system
capability
effective
to
prevent
growth
recurrence.
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
93, С. 105401 - 105401
Опубликована: Янв. 25, 2024
Cancer
is
a
major
public
health
concern
worldwide;
it
the
second-highest
cause
of
death
in
United
States.
According
to
projections
cancer
incidence
and
mortality
rates
throughout
world
for
year
2023,
triple-negative
breast
(TNBC)
expected
be
leading
related
among
women
worldwide.
Traditional
strategies
treatment
TNBC
have
many
drawbacks,
such
as
drug
resistance,
toxicity
etc.
Discovering
novel
delivery
techniques
researching
innovative,
efficient
methods
important.
This
review
discusses
types
subtypes
TNBC.
The
problems
associated
with
standard
therapies,
mechanism
resistance
highlights
need
develop
therapeutic
strategies.
It
provides
information
on
relative
prevalence
severity
cancer.
Several
approaches
viz.
targeted
therapy,
gene
bacterial-mediated
nanomedicine,
immune
checkpoint
inhibitors,
theranostic,
radiotherapy,
chemotherapy,
immunotherapy,
herbal
AI-based
TNBC,
are
discussed
detail.
Additionally,
diagnostic
techniques,
including
imaging
biopsy,
expression
profiling,
mammography,
magnetic
resonance
imaging,
ultrasound,
computed
tomography
scan,
positron
emission
immunohistochemistry,
been
effective
treatment.
in-depth
analysis
innovative
individualized
care
serve
patients
better.
Despite
significant
progress
in
cancer
treatment,
traditional
therapies
still
face
considerable
challenges,
including
poor
targeting,
severe
toxic
side
effects,
and
the
development
of
resistance.
Recent
advances
biotechnology
have
revealed
potential
bacteria
their
derivatives
as
drug
delivery
systems
for
tumor
therapy
by
leveraging
biological
properties.
Engineered
bacteria,
Escherichia
coli,
Salmonella,
Listeria
monocytogenes,
along
with
derivatives─outer
membrane
vesicles
(OMVs),
bacterial
ghosts
(BGs),
spores
(BSPs)─can
be
loaded
a
variety
antitumor
agents,
enabling
precise
targeting
sustained
release
within
microenvironment
(TME).
These
possess
intrinsic
properties
that
stimulate
immune
system,
enhancing
both
innate
adaptive
responses
to
further
amplify
therapeutic
effects.
The
ability
naturally
accumulate
hypoxic
regions
versatility
genetic
modifications
allow
tailored
strategies
synergistically
enhance
effectiveness
chemotherapy,
immunotherapy,
targeted
therapies.
This
review
comprehensively
examines
fundamental
principles
therapy,
focusing
on
employed
engineering,
loading,
use
therapy.
It
also
discusses
challenges
faced
optimizing
systems,
such
safety
concerns,
unintended
responses,
scalability
clinical
applications.
By
exploring
these
aspects,
this
provides
theoretical
framework
improving
bacterial-based
contributing
more
effective
personalized
treatments.
The
terrible
morbidity
and
mortality
of
malignant
tumors
urgently
require
innovative
therapeutics,
especially
for
apoptosis-resistant
tumors.
Pyroptosis,
a
pro-inflammatory
form
programmed
cell
death
(PCD),
is
featured
with
pore
formation
in
plasma
membrane,
swelling
giant
bubbles,
leakage
cytoplasmic
cytokines,
which
can
remodel
the
tumor
immune
microenvironment
by
stimulating
"cold"
to
be
an
immunogenic
"hot"
microenvironment,
consequently
augment
therapeutic
efficiency
Benefiting
from
current
advances
nanotechnology,
nanomedicine
extensively
applied
potentiate,
enable,
pyroptosis
enhancing
cancer-therapeutic
efficacy
specificity.
This
review
provides
concentrated
summary
discussion
most
recent
progress
achieved
this
emerging
field,
highlighting
nanomedicine-enabled/augmented
specific
strategy
favoring
construction
next-generation
nanomedicines
efficiently
induce
PCD.
It
highly
expected
that
further
clinical
translation
accelerated
inducing
pyroptotic
based
on
bioactive
nanomedicines.
Extracellular
vesicles
(EVs),
involved
in
essential
physiological
and
pathological
processes
of
the
organism,
have
emerged
as
powerful
tools
for
disease
treatment
owing
to
their
unique
natural
biological
characteristics
artificially
acquired
advantages.
However,
limited
targeting
ability,
insufficient
production
yield,
low
drug-loading
capability
simplex
EVs
greatly
hindered
development
clinical
translation.
Therefore,
establishment
multifunctional
hybrid
membrane
nanovesicles
(HMNVs)
with
favorable
adaptability
flexibility
has
become
key
expanding
practical
application
EVs.
This
timely
review
summarizes
current
progress
HMNVs
biomedical
applications.
Different
preparation
strategies
including
physical,
chemical,
chimera
approaches
are
first
discussed.
then
individually
describes
diverse
types
based
on
homologous
or
heterologous
cell
substances,
a
fusion
liposome,
well
bacterial
membrane.
Subsequently,
specific
emphasis
is
placed
highlight
applications
toward
various
diseases
representative
examples.
Finally,
ongoing
challenges
prospects
currently
developed
translational
briefly
presented.
will
not
only
stimulate
broad
interest
among
researchers
from
disciplines
but
also
provide
valuable
insights
promising
nanoplatforms
precision
medicine.
In
recent
years,
cancer
immunotherapy
has
undergone
a
transformative
shift
toward
personalized
and
targeted
therapeutic
strategies.
Bacteria-derived
outer
membrane
vesicles
(OMVs)
have
emerged
as
promising
adaptable
platform
for
due
to
their
unique
properties,
including
natural
immunogenicity
the
ability
be
engineered
specific
purposes.
this
review,
comprehensive
overview
is
provided
of
state-of-the-art
techniques
methodologies
employed
in
engineering
versatile
OMVs
immunotherapy.
Beginning
by
exploring
biogenesis
composition
OMVs,
unveiling
intrinsic
immunogenic
properties
appeal.
Subsequently,
innovative
approaches
engineer
are
delved
into,
ranging
from
genetic
parent
bacteria
incorporation
functional
molecules.
The
importance
rational
design
strategies
highlighted
enhance
specificity
allowing
tailoring
diverse
types.
Furthermore,
insights
into
clinical
studies
potential
challenges
utilizing
vaccines
or
adjuvants
also
provided,
offering
assessment
current
landscape
future
prospects.
Overall,
review
provides
valuable
researchers
involved
rapidly
evolving
field
immunotherapy,
roadmap
harnessing
full
treatment.
