Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608

Published: Jan. 1, 2024

Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy

Language: Английский

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Unveiling clinical applications of bacterial extracellular vesicles as natural nanomaterials in disease diagnosis and therapeutics

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 18 - 45

Published: April 17, 2024

Bacterial extracellular vesicles (BEVs) are naturally occurring bioactive membrane-bound nanoparticles released by both gram-negative and gram-positive bacterial species, exhibiting a multifaceted role in mediating host-microbe interactions across various physiological conditions. Increasing evidence supports BEVs as essential mediators of cell-to-cell communicaiton, influencing pathogenicity, disease mechanisms, modulating the host immune response. However, extent to which these BEV-mediated actions can be leveraged predict onset, guide treatment strategies, determine clinical outcomes remains uncertain, particularly terms their translation potentials. This review briefly describes BEV biogenesis internalisation recipient cells summarises methods for isolation characterization, understanding composition cargo. Further, it discusses potential biofluid-associated biomarkers diseases, spanning cancer non-cancerous Following this, we outline ongoing human trials using vaccine development. In addition diagnostics, this explores emerging research natural or engineered smart nanomaterials applications anti-cancer therapy bone regeneration. discussion extends key factors unlocking BEVs, such standardization characterisation, well other hurdles translating findings setting. We propose that addressing through collaborative efforts well-designed holds fully harnessing BEVs. As field advances, suggests BEV-based nanomedicine has revolutionize management, paving way innovative diagnosis, therapeutics, personalized medicine approaches. STATEMENT OF SIGNIFICANCE: Extracellular (EVs) from bacteria serve multifunctional biomaterials fields biomedicine, bioengineering, biomaterials. majority current studies focus on host-derived EVs, leaving gap comprehensive bacteria-derived EVs (BEVs). Although offer an attractive option drug delivery systems, unique nanostructure easy-to-modify functions make them method diagnosis Our work among pioneering investigating nanobiomaterials plays crucial development diseases therapeutic interventions.

Language: Английский

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Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 30, 2024

Oncolytic viruses (OVs) show promise as a cancer treatment by selectively replicating in tumor cells and promoting antitumor immunity. However, the current immunogenicity induced OVs for is relatively weak, necessitating thorough investigation of mechanisms underlying its induction Here, we that HSV-1-based (oHSVs) trigger ZBP1-mediated PANoptosis (a unique innate immune inflammatory cell death modality), resulting augmented effects. Mechanistically, oHSV enhances expression interferon-stimulated genes, leading to accumulation endogenous Z-RNA subsequent activation ZBP1. To further enhance potential oHSV, conduct screening identify Fusobacterium nucleatum outer membrane vesicle (Fn-OMV) can increase execution proteins. The combination Fn-OMV demonstrates potent immunogenicity. Taken together, our study provides deeper understanding oHSV-induced immunity, promising strategy combines with Fn-OMV.

Language: Английский

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Unveiling the Wonders of Bacteria-Derived Extracellular Vesicles: From Fundamental Functions to Beneficial Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42509 - e42509

Published: Feb. 1, 2025

:Extracellular vesicles (EVs), are critical mediators of intercellular communication and exhibit significant potential across various biomedical domains. These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis promising therapeutic applications. EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, nucleic acids, between cells. This review delves into the factors influencing properties EVs, such as temperature stress conditions, which collectively influence size, composition, functional attributes. We also describe emerging emphasizing involvement microbial interactions, immune modulation, antimicrobial resistance spread innovative diagnostic instruments. Despite applications, advancement EV-based therapies faces several challenges, will be discussed. By elucidating these elements, we aim provide a comprehensive overview transformative revolutionizing diagnostics therapeutics medicine.

Language: Английский

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Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 283 - 294

Published: Jan. 25, 2025

Language: Английский

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In silico techniques, artificial intelligence, and machine learning for enhanced efficacy of extracellular vesicle–based diagnosis and therapeutics

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 495 - 521

Published: Jan. 1, 2025

Language: Английский

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Bacterial nanotechnology as a paradigm in targeted cancer therapeutic delivery and immunotherapy

Microsystems & Nanoengineering, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 20, 2024

Cancer, a multifaceted and diverse ailment, presents formidable obstacles to traditional treatment modalities. Nanotechnology novel prospects for surmounting these challenges through its capacity facilitate meticulous regulated administration of therapeutic agents malignant cells while concurrently modulating the immune system combat neoplasms. Bacteria their derivatives have emerged as highly versatile multifunctional platforms cancer nanotherapy within realm nanomaterials. This comprehensive review delves into groundbreaking implementations bacterial nanotechnology therapy. encompasses four primary facets: utilization bacteria living conveyors medicinal substances, employment components that stimulate system, deployment vectors tools delivering genetic material, development bacteria-derived nano-drugs intelligent nano-medications. Furthermore, we elucidate merits modalities operation pertaining nano-systems, along with synergize other cutting-edge nanotechnologies, such CRISPR-Cas systems. Additionally, offer insightful viewpoints regarding forthcoming trajectories this expanding domain. It is our deduction embodies propitious innovative paradigm in therapy, which has potential provide numerous advantages synergistic effects enhancing outcomes quality life individuals afflicted cancer.

Language: Английский

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The Core‐Shell Microneedle with Probiotic Extracellular Vesicles for Infected Wound Healing and Microbial Homeostasis Restoration

Small, Journal Year: 2024, Volume and Issue: 20(46)

Published: Aug. 7, 2024

Abstract Wound healing is a dynamic process involving the timely transition of organized phases. However, infected wounds often experience prolonged inflammation due to microbial overload. Thus, addressing viable treatment needs across different stages critical challenge in wound management. Herein, novel core‐shell microneedle (CSMN) patch designed for sequential delivery tannic acid‐magnesium (TA‐Mg) complexes and extracellular vesicles from Lactobacillus druckerii (LDEVs). Upon application sites, CSMN@TA‐Mg/LDEV releases TA‐Mg first counteract pathogenic overload reduce reactive oxygen species (ROS), aiding proliferative phase. Subsequently, sustained release LDEVs enhances activities keratinocytes fibroblasts, promotes vascularization, modulates collagen deposition. Notably, track composition demonstrates that can both inhibit aggressive pathogen increase diversity at sites. Functional analysis further highlights potential facilitating skin barrier restoration. Moreover, it confirmed accelerate closure improve post‐recovery quality murine wound. Conclusively, this innovative CSMN offers rapid high‐quality alternative emphasizes significance homeostasis.

Language: Английский

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Emerging Trends in Nano-Driven Immunotherapy for Treatment of Cancer

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 458 - 458

Published: Feb. 16, 2023

Despite advancements in the development of anticancer medications and therapies, cancer still has greatest fatality rate due to a dismal prognosis. Traditional therapies include chemotherapy, radiotherapy, targeted therapy. The conventional treatments have number shortcomings, such as lack selectivity, non-specific cytotoxicity, suboptimal drug delivery tumour locations, multi-drug resistance, which results less potent/ineffective therapeutic outcome. Cancer immunotherapy is an emerging promising strategy elicit pronounced immune response against cancer. Immunotherapy stimulates system with cancer-specific antigens or checkpoint inhibitors overcome suppressive microenvironment kill cells. However, antigen activation need circumvent issues pertaining short lifetimes effect times, well adverse effects associated off-targeting, suboptimal, hyperactivation system. Additional challenges posed by are immunogenicity inhibition effector T evolution nanotechnology recent years paved way for improving treatment efficacy facilitating site-specific sustained moiety robust response. amenability nanoparticles towards surface functionalization tuneable physicochemical properties, size, shape, surfaces charge been successfully harnessed immunotherapy, combination therapy, In this review, we summarized made choosing different nanomaterial combinations their modifications enable interaction molecular cellular targets efficient immunotherapy. This review also highlights trends strategies be used independently, combination, destruction cells, prevent metastasis recurrence.

Language: Английский

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Advances in Purification, Modification, and Application of Extracellular Vesicles for Novel Clinical Treatments

Membranes, Journal Year: 2022, Volume and Issue: 12(12), P. 1244 - 1244

Published: Dec. 8, 2022

Extracellular vesicles (EV) are membrane surrounded by a lipid bilayer and include microvesicles, apoptotic bodies, exosomes, exomeres. Exosome-encapsulated microRNAs (miRNAs) released from cancer cells involved in the proliferation metastasis of tumor via angiogenesis. On other hand, mesenchymal stem cell (MSC) therapy, which is being employed regenerative medicine owing to ability MSCs differentiate into various cells, due humoral factors, including messenger RNA (mRNA), miRNAs, proteins, lipids, encapsulated exosomes derived transplanted cells. New treatments that advocate cell-free therapy using MSC-derived will significantly improve clinical practice. Therefore, highly purified perform their original functions desirable. In this review, we summarized advances purification, modification, application EVs as novel strategies treat some diseases.

Language: Английский

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