Shock,
Год журнала:
2023,
Номер
61(2), С. 175 - 188
Опубликована: Окт. 12, 2023
ABSTRACT
Extracellular
vesicles
(EVs)
are
a
new
revelation
in
cross-kingdom
communication,
with
increasing
evidence
showing
the
diverse
roles
of
bacterial
EVs
(BEVs)
mammalian
cells
and
host-microbe
interactions.
Bacterial
include
outer
membrane
released
by
gram-negative
bacteria
generated
from
gram-positive
bacteria.
Recently,
BEVs
have
drawn
attention
for
their
potential
as
biomarkers
therapeutic
tools
because
they
nano-sized
can
deliver
cargo
into
host
cells.
Importantly,
exposure
to
significantly
affects
various
physiological
pathological
responses
Herein,
we
provide
comprehensive
overview
effects
on
(i.e.,
immune
cells,
endothelial
epithelial
cells)
inflammatory/infectious
diseases.
First,
biogenesis
purification
methods
summarized.
Next,
mechanisms
pathways
identified
that
stimulate
either
proinflammatory
or
anti-inflammatory
highlighted.
In
addition,
discuss
which
regulate
interactions
system.
Finally,
this
review
focuses
contribution
pathogenesis
sepsis/septic
shock
treatment
sepsis.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 571 - 608
Опубликована: Янв. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
Acta Biomaterialia,
Год журнала:
2024,
Номер
180, С. 18 - 45
Опубликована: Апрель 17, 2024
Bacterial
extracellular
vesicles
(BEVs)
are
naturally
occurring
bioactive
membrane-bound
nanoparticles
released
by
both
gram-negative
and
gram-positive
bacterial
species,
exhibiting
a
multifaceted
role
in
mediating
host-microbe
interactions
across
various
physiological
conditions.
Increasing
evidence
supports
BEVs
as
essential
mediators
of
cell-to-cell
communicaiton,
influencing
pathogenicity,
disease
mechanisms,
modulating
the
host
immune
response.
However,
extent
to
which
these
BEV-mediated
actions
can
be
leveraged
predict
onset,
guide
treatment
strategies,
determine
clinical
outcomes
remains
uncertain,
particularly
terms
their
translation
potentials.
This
review
briefly
describes
BEV
biogenesis
internalisation
recipient
cells
summarises
methods
for
isolation
characterization,
understanding
composition
cargo.
Further,
it
discusses
potential
biofluid-associated
biomarkers
diseases,
spanning
cancer
non-cancerous
Following
this,
we
outline
ongoing
human
trials
using
vaccine
development.
In
addition
diagnostics,
this
explores
emerging
research
natural
or
engineered
smart
nanomaterials
applications
anti-cancer
therapy
bone
regeneration.
discussion
extends
key
factors
unlocking
BEVs,
such
standardization
characterisation,
well
other
hurdles
translating
findings
setting.
We
propose
that
addressing
through
collaborative
efforts
well-designed
holds
fully
harnessing
BEVs.
As
field
advances,
suggests
BEV-based
nanomedicine
has
revolutionize
management,
paving
way
innovative
diagnosis,
therapeutics,
personalized
medicine
approaches.
STATEMENT
OF
SIGNIFICANCE:
Extracellular
(EVs)
from
bacteria
serve
multifunctional
biomaterials
fields
biomedicine,
bioengineering,
biomaterials.
majority
current
studies
focus
on
host-derived
EVs,
leaving
gap
comprehensive
bacteria-derived
EVs
(BEVs).
Although
offer
an
attractive
option
drug
delivery
systems,
unique
nanostructure
easy-to-modify
functions
make
them
method
diagnosis
Our
work
among
pioneering
investigating
nanobiomaterials
plays
crucial
development
diseases
therapeutic
interventions.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 30, 2024
Oncolytic
viruses
(OVs)
show
promise
as
a
cancer
treatment
by
selectively
replicating
in
tumor
cells
and
promoting
antitumor
immunity.
However,
the
current
immunogenicity
induced
OVs
for
is
relatively
weak,
necessitating
thorough
investigation
of
mechanisms
underlying
its
induction
Here,
we
that
HSV-1-based
(oHSVs)
trigger
ZBP1-mediated
PANoptosis
(a
unique
innate
immune
inflammatory
cell
death
modality),
resulting
augmented
effects.
Mechanistically,
oHSV
enhances
expression
interferon-stimulated
genes,
leading
to
accumulation
endogenous
Z-RNA
subsequent
activation
ZBP1.
To
further
enhance
potential
oHSV,
conduct
screening
identify
Fusobacterium
nucleatum
outer
membrane
vesicle
(Fn-OMV)
can
increase
execution
proteins.
The
combination
Fn-OMV
demonstrates
potent
immunogenicity.
Taken
together,
our
study
provides
deeper
understanding
oHSV-induced
immunity,
promising
strategy
combines
with
Fn-OMV.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42509 - e42509
Опубликована: Фев. 1, 2025
:Extracellular
vesicles
(EVs),
are
critical
mediators
of
intercellular
communication
and
exhibit
significant
potential
across
various
biomedical
domains.
These
nano-sized,
membrane-encapsulated
entities
have
captured
substantial
interest
due
to
their
diverse
roles
in
pathogenesis
promising
therapeutic
applications.
EVs
manage
numerous
physiological
processes
by
transferring
bioactive
molecules,
including
proteins,
lipids,
nucleic
acids,
between
cells.
This
review
delves
into
the
factors
influencing
properties
EVs,
such
as
temperature
stress
conditions,
which
collectively
influence
size,
composition,
functional
attributes.
We
also
describe
emerging
emphasizing
involvement
microbial
interactions,
immune
modulation,
antimicrobial
resistance
spread
innovative
diagnostic
instruments.
Despite
applications,
advancement
EV-based
therapies
faces
several
challenges,
will
be
discussed.
By
elucidating
these
elements,
we
aim
provide
a
comprehensive
overview
transformative
revolutionizing
diagnostics
therapeutics
medicine.
Abstract
Wound
healing
is
a
dynamic
process
involving
the
timely
transition
of
organized
phases.
However,
infected
wounds
often
experience
prolonged
inflammation
due
to
microbial
overload.
Thus,
addressing
viable
treatment
needs
across
different
stages
critical
challenge
in
wound
management.
Herein,
novel
core‐shell
microneedle
(CSMN)
patch
designed
for
sequential
delivery
tannic
acid‐magnesium
(TA‐Mg)
complexes
and
extracellular
vesicles
from
Lactobacillus
druckerii
(LDEVs).
Upon
application
sites,
CSMN@TA‐Mg/LDEV
releases
TA‐Mg
first
counteract
pathogenic
overload
reduce
reactive
oxygen
species
(ROS),
aiding
proliferative
phase.
Subsequently,
sustained
release
LDEVs
enhances
activities
keratinocytes
fibroblasts,
promotes
vascularization,
modulates
collagen
deposition.
Notably,
track
composition
demonstrates
that
can
both
inhibit
aggressive
pathogen
increase
diversity
at
sites.
Functional
analysis
further
highlights
potential
facilitating
skin
barrier
restoration.
Moreover,
it
confirmed
accelerate
closure
improve
post‐recovery
quality
murine
wound.
Conclusively,
this
innovative
CSMN
offers
rapid
high‐quality
alternative
emphasizes
significance
homeostasis.
Microsystems & Nanoengineering,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 20, 2024
Cancer,
a
multifaceted
and
diverse
ailment,
presents
formidable
obstacles
to
traditional
treatment
modalities.
Nanotechnology
novel
prospects
for
surmounting
these
challenges
through
its
capacity
facilitate
meticulous
regulated
administration
of
therapeutic
agents
malignant
cells
while
concurrently
modulating
the
immune
system
combat
neoplasms.
Bacteria
their
derivatives
have
emerged
as
highly
versatile
multifunctional
platforms
cancer
nanotherapy
within
realm
nanomaterials.
This
comprehensive
review
delves
into
groundbreaking
implementations
bacterial
nanotechnology
therapy.
encompasses
four
primary
facets:
utilization
bacteria
living
conveyors
medicinal
substances,
employment
components
that
stimulate
system,
deployment
vectors
tools
delivering
genetic
material,
development
bacteria-derived
nano-drugs
intelligent
nano-medications.
Furthermore,
we
elucidate
merits
modalities
operation
pertaining
nano-systems,
along
with
synergize
other
cutting-edge
nanotechnologies,
such
CRISPR-Cas
systems.
Additionally,
offer
insightful
viewpoints
regarding
forthcoming
trajectories
this
expanding
domain.
It
is
our
deduction
embodies
propitious
innovative
paradigm
in
therapy,
which
has
potential
provide
numerous
advantages
synergistic
effects
enhancing
outcomes
quality
life
individuals
afflicted
cancer.
Vaccines,
Год журнала:
2023,
Номер
11(2), С. 458 - 458
Опубликована: Фев. 16, 2023
Despite
advancements
in
the
development
of
anticancer
medications
and
therapies,
cancer
still
has
greatest
fatality
rate
due
to
a
dismal
prognosis.
Traditional
therapies
include
chemotherapy,
radiotherapy,
targeted
therapy.
The
conventional
treatments
have
number
shortcomings,
such
as
lack
selectivity,
non-specific
cytotoxicity,
suboptimal
drug
delivery
tumour
locations,
multi-drug
resistance,
which
results
less
potent/ineffective
therapeutic
outcome.
Cancer
immunotherapy
is
an
emerging
promising
strategy
elicit
pronounced
immune
response
against
cancer.
Immunotherapy
stimulates
system
with
cancer-specific
antigens
or
checkpoint
inhibitors
overcome
suppressive
microenvironment
kill
cells.
However,
antigen
activation
need
circumvent
issues
pertaining
short
lifetimes
effect
times,
well
adverse
effects
associated
off-targeting,
suboptimal,
hyperactivation
system.
Additional
challenges
posed
by
are
immunogenicity
inhibition
effector
T
evolution
nanotechnology
recent
years
paved
way
for
improving
treatment
efficacy
facilitating
site-specific
sustained
moiety
robust
response.
amenability
nanoparticles
towards
surface
functionalization
tuneable
physicochemical
properties,
size,
shape,
surfaces
charge
been
successfully
harnessed
immunotherapy,
combination
therapy,
In
this
review,
we
summarized
made
choosing
different
nanomaterial
combinations
their
modifications
enable
interaction
molecular
cellular
targets
efficient
immunotherapy.
This
review
also
highlights
trends
strategies
be
used
independently,
combination,
destruction
cells,
prevent
metastasis
recurrence.
