Copper(II)-Complexed Polyethylenimine-Entrapped Gold Nanoparticles Enable Targeted CT/MR Imaging and Chemodynamic Therapy of Tumors DOI Open Access
Lulu He, Na Liu, Rongqing Pan

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 423 - 423

Published: Feb. 6, 2025

Transition-metal ion copper(II) (Cu(II)) has drawn increasing attention as a small-molecular cancer theranostic agent. However, delivering sufficient dosage of Cu(II) to the tumor site and integrating multiple imaging modalities achieve precise effective theranostics remains critical challenge. Herein, an emerging Cu(II)-based nanocomposite been synthesized for targeted computed tomography (CT)/magnetic resonance (MR) dual-mode chemodynamic therapy (CDT). Briefly, 2-picolinic acid (PA-COOH), polyethylene glycol (PEG)-linked folic (FA), fluorescein isothiocyanate (FI) were sequentially conjugated with polyethylenimine (PEI.NH2) then in situ fabrication gold nanoparticles (Au NPs) occurred within PEI.NH2 internal cavity. After acetylation terminal amines complexation, nanocomposites FA-Au/Cu(II) PENPs mean diameter 2.87 nm generated. The showed favorable stability colloidal dispersion, sustainable release properties pH-dependent manner, Fenton-like catalytic activity specifically. With FA-mediated targeting pathway, can specifically accumulate cells high expression FA receptors. Meanwhile, complementary CT/MR vitro vivo be afforded by based on excellent X-ray attenuation Au NPs applicable r1 relaxivity (0.7378 mM−1s−1) Cu(II). Notably, Cu(II)-mediated CDT mechanism enables elicit generation toxic hydroxyl radicals (·OH), depletion glutathione (GSH), promotion lipid peroxidation (LPO), induction cell apoptosis vitro, further demonstrates remarkable anti-tumor efficacy xenograft model. illustrated capacity towards tumors, this paradigm inspires construction advanced nanoplatforms incorporating alternative transition metal ions.

Language: Английский

Covalent organic frameworks (COFs) and metal–organic frameworks (MOFs) as electrochemical sensors for the efficient detection of pharmaceutical residues DOI Creative Commons
Brij Mohan,

Ritu Kumari,

Virender Virender

et al.

Environment International, Journal Year: 2023, Volume and Issue: 175, P. 107928 - 107928

Published: April 11, 2023

Pharmaceutical residues are the undecomposed remains from drugs used in medical and food industries. Due to their potential adverse effects on human health natural ecosystems, they of increasing worldwide concern. The acute detection pharmaceutical can give a rapid examination quantity then prevent them further contamination. Herein, this study summarizes discusses most recent porous covalent-organic frameworks (COFs) metal–organic (MOFs) for electrochemical various residues. review first introduces brief overview drug toxicity its living organisms. Subsequently, different materials techniques discussed with materials' properties applications. Then development COFs MOFs has been addressed structural sensing Further, stability, reusability, sustainability MOFs/COFs reviewed discussed. Besides, MOFs' limits, linear ranges, role functionalities, immobilized nanoparticles analyzed Lastly, summarized [email protected] composite as sensors, fabrication strategies enhance potential, current challenges area.

Language: Английский

Citations

78
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy DOI
Sankha Bhattacharya, Bhupendra G. Prajapati, Sudarshan Singh

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103961 - 103961

Published: March 13, 2023

Language: Английский

Citations

54
Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy DOI
Zheng Wang,

Shuo Pang,

Xiaoli Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

Citations

36
Recent advances and clinical challenges of phototherapeutic nanoparticles in cancer monotherapy or combination therapy DOI
Yuanying Zhang,

Yanling Zhang,

Gege Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216069 - 216069

Published: July 15, 2024

Language: Английский

Citations

14
Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution DOI Creative Commons
Sheeja S. Rajan, Rahul Chandran, Heidi Abrahamse

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 1, 2024

Abstract Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as transformative force in cancer treatment, particularly through nano‐enabled photodynamic therapy (NE‐PDT), which leverages precise and targeted interventions. NE‐PDT capitalizes on photosensitizers activated by light generate reactive oxygen species (ROS) initiate apoptotic pathways cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, ROS production within tumors. This review dissects NE‐PDT's mechanistic framework, showcasing its potential harness apoptosis potent tool therapy. Furthermore, the explores synergy between complementary treatments like chemotherapy, immunotherapy, therapies, highlighting amplify responses, enhance immune recognition of cells, inhibit resistance mechanisms. Preclinical clinical advancements demonstrate efficacy across various types. Challenges translating into practice are also addressed, emphasizing need for optimizing nanoparticle design, refining dosimetry, ensuring long‐term safety. Ultimately, represents promising approach therapy, utilizing intricate mechanisms address therapeutic hurdles. The underscores importance understanding interplay nanoparticles, generation, pathways, contributing deeper comprehension biology novel strategies. As interdisciplinary collaborations continue thrive, offers hope effective interventions, where manipulation becomes central conquering cancer. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease

Language: Английский

Citations

10
A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors DOI

Zihan Xing,

Linwei Li, Tao Liao

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 244 - 258

Published: April 6, 2024

Language: Английский

Citations

9
Ti3C2Tx MXene nanosheet-based drug delivery/cascaded enzyme system for combination cancer therapy and anti-inflammation DOI
Qianqian Qiao, Jinyu Wang,

B Q Li

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102215 - 102215

Published: May 3, 2024

Language: Английский

Citations

9
Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications DOI Open Access
Yong Pan, Han Zhao, Wenyong Huang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

Citations

1
An overview on recent biomedical applications of biopolymers: Their role in drug delivery systems and comparison of major systems DOI
Murtaza Syed, Mior Ahmad Khushairi Mohd Zahari, Md. Maksudur Rahman Khan

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 80, P. 104121 - 104121

Published: Dec. 29, 2022

Language: Английский

Citations

30
Recent advances in recurrent hepatocellular carcinoma therapy DOI Open Access

Yuxue Gao,

Qi-Qi Ning,

Pengxiang Yang

et al.

World Journal of Hepatology, Journal Year: 2023, Volume and Issue: 15(4), P. 460 - 476

Published: April 20, 2023

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, accounting for 75%-85% cases. Although treatments are given to cure early-stage HCC, up 50%-70% individuals may experience a relapse illness in after 5 years. Research on fundamental treatment modalities recurrent HCC moving significantly further. The precise selection therapy strategies with established survival advantages crucial ensuring better outcomes. These aim minimize substantial morbidity, support good life quality, and enhance patients HCC. For recurring curative treatment, no approved therapeutic regimen currently available. A recent study presented novel approaches, like immunotherapy antiviral medication, improve prognosis apparent lack data guide clinical treatment. supporting several neoadjuvant adjuvant therapies outlined this review. We also discuss potential future translational investigations.

Language: Английский

Citations

17