Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects DOI Creative Commons
Danni Dai, Dan Li, Chao Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(40)

Published: Aug. 29, 2024

Abstract The demineralization of dental hard tissue imposes considerable health and economic burdens worldwide, but an optimal method that can repair both the chemical composition complex structures has not been developed. continuous development nanotechnology created new opportunities for regeneration tissue. Increasingly studies have reported nanomaterials (NMs) induce regulate biomimetic mineralization tissue, few examined how they are involved in different stages, let alone relevant mechanisms action. Besides their nanoscale dimensions excellent designability, NMs play a corresponding role function raw materials mineralization, mineralized microenvironment, guidance, products. This review comprehensively summarizes advantages examines specific mechanisms. Design strategies to promote summarized according application purpose oral cavity, limitations directions remineralization proposed. provide theoretical basis understand interaction between thereby optimizing design strategy, rational development, clinical field remineralization.

Language: Английский

Janus Membrane with Intrafibrillarly Strontium-Apatite-Mineralized Collagen for Guided Bone Regeneration DOI

Yaning Zhao,

Wei Sun, Xiaoyi Wu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 7204 - 7222

Published: Feb. 19, 2024

Commercial collagen membranes face difficulty in guided bone regeneration (GBR) due to the absence of hierarchical structural design, effective interface management, and diverse bioactivity. Herein, a Janus membrane called SrJM is developed that consists porous enhance osteogenic function dense maintain barrier function. Specifically, biomimetic intrafibrillar mineralization with strontium apatite realized by liquid precursors amorphous phosphate. Polycaprolactone methacryloyl further integrated on one side as face, which endows mechanical support prolonged lifespan. In vitro experiments demonstrate acts strong against fibroblasts, while significantly promotes cell adhesion differentiation through activation calcium-sensitive receptor/integrin/Wnt signaling pathways. Meanwhile, effectively enhances osteogenesis angiogenesis recruiting stem cells modulating osteoimmune response, thus creating an ideal microenvironment for regeneration. vivo studies verify defect region completely repaired newly formed vascularized bone. Overall, outstanding performance supports its ongoing development multifunctional GBR membrane, this study provides versatile strategy fabricating collagen-based biomaterials hard tissue

Language: Английский

Citations

21
Urchin-like multiscale structured fluorinated hydroxyapatite as versatile filler for caries restoration dental resin composites DOI Creative Commons
S. D. Zhang, Xiao Wang,

Shi Yin

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 477 - 494

Published: Feb. 19, 2024

Caries is one of the most prevalent human diseases, resulting from demineralization tooth hard tissue caused by acids produced bacteria, and can progress to pulpal inflammation. Filling restoration with dental resin composites (DRCs) currently common treatment for caries. However, existing DRCs suffer low fracture strength lack comprehensive anti-caries bioactivity including remineralization, pulp protection, anti-cariogenic bacteria effects. In this study, inspired plant roots' ability stabilize improve soil, fluorinated urchin-like hydroxyapatite (FUHA) a three-dimensional whisker structure bioactive components calcium, phosphorus, fluorine was designed synthesized dynamic self-assembly method. Furthermore, versatile FUHA particles different loading fractions were used as functional fillers fabricate methacrylate-based DRCs, where (UHA) filled commercial (Z350XT BEAUTIFIL II) served control groups. The results demonstrated that 50 wt% in matrix endowed DRC (F5) excellent physicochemical properties, dentin remineralization property, cell viability, promotion stem cells mineralization, antibacterial properties. Meanwhile, F5 also presented good clinical handling aesthetic characteristics. Therefore, structure/functional-integrated have potential promising strategy bioactivity.

Language: Английский

Citations

13
Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections DOI
Junjie Zhang,

Ming Liu,

Haiyang Guo

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

Citations

13
Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics DOI
Zhao Rui,

Hui Qian,

Xiangdong Zhu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: May 6, 2024

Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.

Language: Английский

Citations

9
Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches DOI

Qingyi Yang,

Wenqian Zheng,

Yuping Zhao

et al.

Dental Materials, Journal Year: 2024, Volume and Issue: 40(8), P. 1282 - 1295

Published: June 13, 2024

Language: Английский

Citations

9
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy DOI
Yujie Pan, Yangyang Li, Xin Zhou

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

The management of diabetic wounds faces significant challenges due to the excessive activation reactive oxygen species (ROS), dysregulation inflammatory response, and impaired angiogenesis. A substantial body evidence suggests that aforementioned diverse factors contributing delayed healing may be associated with autophagy. Impaired autophagy leads endothelial fibroblast dysfunction impedes macrophage phenotypic transformation. This disruption hinders angiogenesis extracellular matrix deposition, ultimately culminating in wound healing. Therefore, biomaterials possessing regulatory functions hold potential for clinical applications enhancing wounds. hybrid multifunctional hydrogel (GelMa@SIS-Qu) has been developed, comprising methacrylamide gelatin (GelMa), a small intestine submucosal acellular (SIS), quercetin nanoparticles, which demonstrates capability promote promotion not only reduces ROS levels cells enhances their antioxidant activity but also mitigates ROS-induced cell apoptosis, thereby promoting Furthermore, facilitates transformation macrophages from M1 phenotype M2 phenotype. study investigates distinctive mechanisms GelMa@SIS-Qu proposes promising therapeutic strategy treating diabetes-related

Language: Английский

Citations

1
In-depth Occlusion of Dentinal Tubules Induced by Polyaspartic Acid–Calcium and Magnesium Complexes DOI
Dan Shen, Haihua Zhu,

Yanhua Xu

et al.

Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Dentin hypersensitivity has been widely recognized to be caused by patent dentinal tubules (DTs). A polyaspartic acid-calcium and magnesium (PAsp-Ca&Mg) complex process demonstrated induce biomimetic mineralization of collagen fibrils. This study investigated the in vitro vivo occlusion DTs a PAsp-Ca&Mg process. disks were treated citric acid open randomly divided into 4 groups. Two experimental groups (n = 18) applied with suspension phosphate solution or phosphate-fluoride sequence for 10 min. positive control Gluma Duraphat. All dentin incubated artificial saliva 24 h. DT was characterized scanning electron microscopy, permeability measurement conducted regardless being subject abrasive ultrasonic acidic challenge. The incisors 3 New Zealand rabbits used verify DTs. In results in-depth ~100 μm When compared groups, could significantly reduce (P < 0.05) irrespective not only deeply occluded but also decreased provided paradigm ion-doped occlusion. provides promising strategy managing hypersensitivity.

Language: Английский

Citations

1
Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion DOI Creative Commons
Qun Li, Jin‐Biao Liu, Huijie Liu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 72 - 84

Published: June 29, 2023

Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting demineralization decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) designed for caries prevention tooth remineralization. MPC can intelligently release antibacterial molecules (gallic acid) mineralized ions (Mg2+, Ca2+ PO43-) under acidic conditions (pH < 5.5) infection, regulating pH killing bacteria. Additionally, due excellent photothermal conversion efficiency, further enhance destruction by inhibiting virulence genes destroying adhesion near-infrared light irradiation (808 nm). More importantly, not only reverse cariogenic environment at both microbial levels, but also promote self-healing demineralized teeth terms micro-structure mechanical properties.

Language: Английский

Citations

18
Effects of Green Tea Extract Epigallocatechin-3-Gallate on Oral Diseases: A Narrative Review DOI Creative Commons
Yizhen Li, Lei Cheng, Mingyun Li

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(8), P. 634 - 634

Published: July 29, 2024

Oral diseases are among the most prevalent globally. Accumulating new evidence suggests considerable benefits of epigallocatechin-3-gallate (EGCG) for oral health. This review aims to explore role and application EGCG in main diseases.

Language: Английский

Citations

7
Dual-Targeting EGCG/NO-Supplying protein assembled nanoparticles with Multi-Synergistic effects against atherosclerosis DOI

Chi Lin,

Tsai-Mu Cheng, Yunchun Liu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152755 - 152755

Published: June 1, 2024

Language: Английский

Citations

6