Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102772 - 102772
Published: Feb. 5, 2025
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: May 31, 2024
Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.
Language: Английский
Citations
23
Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103086 - 103086
Published: Feb. 13, 2024
Hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), has been implicated in the development of persistent cognitive impairment, significantly compromising quality life for affected individuals. Nevertheless, precise underlying mechanism remains elusive. Here, we report first time that accumulation iron within hippocampus, distal to site ICH striatum, is causally linked observed impairment with both clinical patient data and animal model. Both susceptibility-weighted imaging (SWI) quantitative susceptibility mapping (QSM) demonstrated significant hippocampus patients, which far from actual hematoma. Logistical regression analysis multiple linear identified level as an independent risk factor a negative correlation post-ICH impairment. Using mouse model ICH, triggers excessive activation neural stem cells (NSCs). This overactivation subsequently leads depletion NSC pool, diminished neurogenesis, onset progressive dysfunction. Mechanistically, elevated levels reactive oxygen species (ROS), downregulated expression Itga3. Notably, pharmacological chelation or scavenger aberrant ROS levels, well conditionally overexpressed Itga3 NSCs, remarkably attenuated exhaustion abnormal neurogenesis decline ICH. Together, these results provide molecular insights into ICH-induced shedding light on value maintaining pool preventing dysfunction patients hemorrhagic stroke related conditions.
Language: Английский
Citations
19
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
7
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 557 - 579
Published: Jan. 1, 2025
Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches. Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, nanoparticle tracking analysis, then applied in cellular models mouse of cardiac fibrosis. Western blotting qRT-PCR used identify protective signaling pathways fibroblasts (CFs). Young-sEVs significantly inhibited fibrosis subsequent dysfunction post-myocardial infarction (MI) mice. The main findings included that echocardiographic assessments four weeks post-MI indicated improved left ejection fraction (LVEF) fractional shortening (LVFS), reduced internal diameter diastole (LVIDd) systole (LVIDs). Treatment with also decreased Masson-positive fibroblast areas collagen synthesis tissue. However, sEVs the old control group did not achieve above effect. Consistent vivo results, could inhibit proliferation, migration, CFs TGF-β1-induced model. High-throughput microRNA (miRNA) sequencing analysis revealed miR-664a-3p was abundant Young-sEVs. high expression CFs. suppressing eliminated their effect on Further studies confirmed SMAD4 as direct downstream target miR-664a-3p, whose overexpression reverse anti-fibrotic effects miR-664a-3p. In summary, these firstly directly bind 3'-untranslated region mRNA through thereby inhibiting TGF-β/SMAD4 pathway protect improve function. Considering ease obtaining plasma-derived sEVs, our study offers promising strategy for potential rapid clinical translation near future.
Language: Английский
Citations
2
Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 276, P. 111358 - 111358
Published: March 4, 2024
Language: Английский
Citations
13
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570
Published: Aug. 29, 2024
Language: Английский
Citations
10
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102545 - 102545
Published: Oct. 17, 2024
Language: Английский
Citations
10
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: Sept. 26, 2024
Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.
Language: Английский
Citations
9
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Feb. 2, 2024
Abstract Non-traumatic intracerebral hemorrhage (ICH) is the most common type of hemorrhagic stroke, often occurring between ages 45 and 60. Hypertension cause ICH. Less often, atherosclerosis, blood diseases, inflammatory changes in cerebral vessels, intoxication, vitamin deficiencies, other reasons hemorrhages. Cerebral can occur by diapedesis or as a result ruptured vessel. This very dangerous disease difficult to treat, requires surgery lead disability death. MicroRNAs (miRNAs) are class non-coding RNAs (about 18-22 nucleotides) that involved variety biological processes including cell differentiation, proliferation, apoptosis, etc., through gene repression. A growing number studies have demonstrated miRNAs deregulation various cardiovascular In addition, given computed tomography (CT) and/or magnetic resonance imaging (MRI) either not available do show clear signs possible vessel rupture, accurate reliable analysis circulating fluids help early diagnosis for prevention ICH prognosis patient outcome after hemorrhage. this review, we highlight up-to-date findings on deregulated ICH, potential use clinical settings, such therapeutic targets non-invasive diagnostic/prognostic biomarker tools.
Language: Английский
Citations
8
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: June 10, 2024
This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung even offering solutions for conditions like myocardial infarction renal ischemia-reperfusion injury, demonstrate promising efficacy. Their adaptability different administration routes identifying specific factors opens avenues innovative regenerative strategies. positions candidates future clinical applications, providing a overview medicine.
Language: Английский
Citations
8