Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 22, 2024
Sericin,
a
protein
derived
from
silkworm
cocoons,
is
considered
waste
product
the
silk
industry
for
thousands
of
years
due
to
lack
understanding
its
properties.
However,
in
recent
decades,
range
exciting
properties
sericin
are
studied
and
uncovered,
including
cytocompatibility,
low-immunogenicity,
photo-luminescence,
antioxidant
properties,
as
well
cell-function
regulating
activities.
These
make
sericin-based
biomaterials
promising
candidates
biomedical
applications.
This
review
summarizes
bioactivities
highlights
latest
developments
tissue
engineering
regenerative
medicine.
Furthermore,
extended
application
developing
flexible
electronic
devices
3D
bioprinting
also
discussed.
It
believed
that
have
great
potential
being
developed
into
novel
products
smart
implantable
various
medical
applications
toward
improving
clinical
outcomes.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes,
which
are
small
vesicles
enclosed
by
a
lipid
bilayer
and
released
many
cell
types,
widely
dispersed
have
garnered
increased
attention
in
the
field
of
regenerative
medicine
due
to
their
ability
serve
as
indicators
diseases
agents
with
therapeutic
potential.
Exosomes
play
crucial
role
mediating
intercellular
communication
through
transfer
biomolecules,
including
proteins,
lipids,
RNA,
other
molecular
constituents,
between
cells.
The
targeted
transport
proteins
nucleic
acids
specific
cells
has
potential
enhance
or
impair
biological
functions.
applications,
they
can
be
used
alone
combination
approaches.
examination
unique
attributes
functions
these
factors
emerged
prominent
study
realm
biomedical
research.
This
manuscript
summarizes
origins
properties
exosomes,
structural,
biological,
physical,
chemical
aspects.
paper
offers
complete
recent
progress
tissue
repair
medicine,
emphasizing
possible
implications
methods
forthcoming
regeneration
attempts.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Giant,
Journal Year:
2024,
Volume and Issue:
18, P. 100251 - 100251
Published: March 6, 2024
The
treatment
of
diabetic
wounds
is
a
major
challenge
faced
by
the
medical
system,
and
there
growing
interest
in
developing
innovative
therapies
to
accelerate
wound
healing.
Regenerative
medicine
with
cells
has
shown
promising
potential
skin
repair,
regenerative
properties
primarily
attributed
paracrine
effects
secreted
products,
including
exosomes.
Compared
cell-based
approaches,
using
exosomes
as
cell-free
therapy
for
chronic
several
advantages.
Exosomes
can
regulate
intercellular
communication
releasing
their
contents,
mRNA,
miRNA,
lipids,
proteins,
which
further
promote
are
well
explored
biomedical
application
owing
advantages
such
biocompatibility
low
immunogenicity.
However,
common
method
exosome
administration
through
injection,
but
due
rapid
clearance
rate
body,
maintaining
necessary
therapeutic
concentration
around
challenging.
Therefore,
it
develop
new
biocompatible
scaffold
carrier
extracellular
vesicles,
allowing
them
sustain
at
non-healing
sites
continuously
Engineered
kinds
modified
internal
treated
molecules,
surface
decoration
or
delivered
engineered
platform.
In
addition,
some
researchers
have
processed
exosomes,
known
decoration,
delivery
platforms.
regular
greater
promoting
this
review,
we
summarize
molecular
mechanisms
from
different
sources
varying
modifications
Advantages
limitations
repair
were
also
discussed.
Finally,
highlight
challenges
future
development
directions
translating
our
knowledge
into
clinical
practice.
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
