Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151728 - 151728
Published: April 27, 2024
Language: Английский
ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(8), P. 2204 - 2214
Published: July 24, 2024
DNA nanostructures have been widely researched in recent years as emerging biomedical materials for drug delivery, biosensing, and cancer therapy, addition to their hereditary function. Multiple precisely designed single-strand DNAs can be fabricated into complex, three-dimensional through a simple self-assembly process. Among all of the synthetic nanostructures, tetrahedral (TDNs) stand out most promising nanomaterial. TDNs possess merits structural stability, cell membrane permeability, natural biocompatibility due compact structures origin. In inherent advantages, were shown great potential delivering therapeutic agents multiple functional modifications. As multifunctional material, enabled innovative pharmaceutical applications, including antimicrobial anticancer treatment, immune modulation, cartilage regeneration. Given rapid development field, it is critical understand how successfully produce fine-tune properties specific needs clinical translation. This article provides insights synthesis functionalization summarizes approaches TDN-based therapeutics delivery well broad applications field pharmaceutics nanomedicine, challenges, future directions.
Language: Английский
Citations
4
Biotechnology Advances, Journal Year: 2024, Volume and Issue: 76, P. 108436 - 108436
Published: Aug. 28, 2024
Language: Английский
Citations
4
Chemosensors, Journal Year: 2025, Volume and Issue: 13(1), P. 17 - 17
Published: Jan. 15, 2025
Telomeres play a key role in maintaining chromosome stability and cellular aging. They consist of repetitive DNA sequences that protect ends regulate cell division. Telomerase is reverse transcriptase enzyme counteracts the natural shortening telomeres during division by extending them. Its activity pivotal stem cells cancer but absent most normal somatic cells. Recent advances biosensor technologies have facilitated situ detection telomerase activity, which essential for understanding its aging cancer. Techniques such as fluorescence, electrochemistry, nanotechnology are now being employed to monitor living cells, providing real-time insights into processes. DNA-based biosensors, especially those incorporating molecular beacons, walkers, logic gates, shown promise enhancing sensitivity specificity imaging. These approaches also facilitate simultaneous analysis related pathways, offering potential applications early precision therapies. This review explores recent developments intracellular imaging, highlighting innovative DNA-functionalized nanoparticles multi-channel systems, offer non-invasive, complex environments.
Language: Английский
Citations
0
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)
Published: Jan. 18, 2025
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Abstract Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of antigens, low infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability precisely engineer, controlled release, biocompatibility, capability augment immunogenicity microenvironment, have gained significant attention for potential revolutionize vaccine designing. This review summarizes various applications in construction situ cancer vaccines, which can generate tumor‐associated antigens directly damaged tumors immune‐stimulation. The mechanisms components are listed, specific strategies constructing using explored underlying action elucidated. immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic (PDT), radiation (RT) related building systematically summarized. different immunotherapy elaborated, exerts precise, long‐lasting, robust responses. current challenges future prospectives proposed. provides a holistic understanding evolving role development.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Abstract Developing nanoscale platforms with high integration, assembly efficiency, and structural stability for performing complex computations in specific cells remains a significant challenge. To address this, the Three‐dimensional Hierarchical Octahedral Robotic (THOR) DNA nanoplatform is introduced, which integrates targeting, logic computation, sensing modules within single framework. This specifically binds to cancer cell surface proteins, releasing aptamer‐linked fuel chains initiate subsequent computational processes. Three gates efficiently compute any arbitrary binary combination of target proteins. The module employs catalytic hairpin detecting miRNAs sensitivity. THOR demonstrates robust functionality both vitro situ. As proof‐of‐concept, this distinguish acute lymphoblastic leukemia (ALL) patients from other subtypes healthy participants, achieving 100% accuracy applied. Additionally, approach reliably monitored therapeutic progress ALL patients, showing strong concordance bone marrow smear results. platform highlights feasibility constructing reliable, hierarchical, multifunctional analytical system based on polyhedron. It offers promising auxiliary tool clinical diagnostics monitoring.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Well-defined nanostructures (WDNSs) represent a transformative frontier in nanotechnology, enabling precise control over material properties through nanoscale engineering. The connectivity of building blocks is increasingly critical defining the and applications WDNSs. Traditional dimensionality-based classifications provide foundational insights but overlook delicate influence architectures on functionality. This perspective introduces supplementary classification framework based modes, including discrete connections, serial 2.5D 3D interpenetrations. Each category defines specific structural configurations that decide spatial arrangement, interaction dynamics, functional integration components. establishes unique for understanding WDNSs, linking their design with diverse catalysis, energy storage, biomedicine, beyond. By regulating strategies emerging demands, WDNSs offer considerable opportunities designing multifunctional materials, providing foundation advancing nanotechnology addressing complex scientific societal challenges. Finally, advanced rational design, accurate synthesis, comprehensive deployment, sustainable development remain to bottlenecks development.
Language: Английский
Citations
0
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)
Published: March 11, 2025
Abstract An electrochemical DNA biosensor is presented for early viral infection detection, integrating molybdenum disulphide (MoS₂), tetrahedral nanostructures (TDNs), and thionine-modified carbon nanodots (CNDsTy). The innovation of this work lies in the first-time integration these nanomaterials preparation a bioconjugate, whose synergy enables biosensor’s functionality. MoS₂ anchors TDNs, which carry capture probe virus identification via genetic code recognition. CNDsTy allow detection based on their different affinity single-stranded (ssDNA) double-stranded (dsDNA), enabling hybridization event identification. achieves high sensitivity (detection limit 5.00 fM) can distinguish loads, validated with SARS-CoV-2 ORF1ab sequence human nasopharyngeal samples. Graphical
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Fibroblast phenotypic transformation plays a crucial role in tumorigenesis. Tumor cell-derived exosome-mediated fibroblast has been commonly studied. However, there is still no direct evidence that the process of tumor exosomes induces fibroblasts into cancer-associated (CAFs). Herein, exosomal miRNAs were used as target to track invasion cancer normal fibroblasts, and FAP mRNA, CAF biomarker, further trace effect on recipient cells. Two DNA tetrahedral sensors developed based hybrid chain reaction signal amplification strategy fluorescence resonance energy transfer mechanism. Both showed high sensitivity good selectivity, with detection limits 4.94 6.61 pM for miR-1247-3p respectively. Moreover, two allowed us image living cell postinvasion tumor-derived exosomes, facilitating visual monitoring phenotype uncovering new perspectives metastasis development.
Language: Английский
Citations
0