Renoprotective effect of the antioxidant curcumin: Recent findings

Redox Biology, Journal Year: 2013, Volume and Issue: 1(1), P. 448 - 456

Published: Jan. 1, 2013

For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used Asia spice, pigment and additive. In traditional medicine India China, curcumin considered agent several foods. Numerous shown that has broad biological functions particularly antioxidant antiinflammatory. fact, it established bifunctional antioxidant; exerts activity direct an indirect way by scavenging reactive oxygen species inducing response, respectively. The renoprotective effect evaluated experimental models including diabetic nephropathy, chronic renal failure, ischemia reperfusion nephrotoxicity induced such gentamicin, adriamycin, chloroquine, iron nitrilotriacetate, sodium fluoride, hexavalent chromium cisplatin. It recently model failure effect; fact reverts not only systemic alterations but also glomerular hemodynamic changes. Another recent finding shows associated to preservation function redox balance mitochondria. Taking together, these attribute protective kidney induction master regulator response nuclear factor erythroid-derived 2 (Nrf2), inhibition mitochondrial dysfunction, attenuation inflammatory enzymes prevention oxidative stress. information presented this paper identifies promising molecule against injury.

Language: Английский

---

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

Molecules, Journal Year: 2015, Volume and Issue: 20(5), P. 9183 - 9213

Published: May 20, 2015

It is extensively verified that continued oxidative stress and damage may lead to chronic inflammation, which in turn can mediate most diseases including cancer, diabetes, cardiovascular, neurological, inflammatory bowel disease pulmonary diseases. Curcumin, a yellow coloring agent extracted from turmeric, shows strong anti-oxidative anti-inflammatory activities when used as remedy for the prevention treatment of How activates pathways leading progression focus this review. Thus, research date suggests stress, are closely linked, antioxidant properties curcumin play key role inflammation

Language: Английский

---

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

Current Neuropharmacology, Journal Year: 2013, Volume and Issue: 11(4), P. 338 - 378

Published: June 1, 2013

Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India food preparation for medicinal purposes. Since second half of last century, this traditional medicine has attracted attention scientists multiple disciplines to elucidate its pharmacological properties. Of significant interest curcumin's role treat neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's (PD) malignancy. These all share an inflammatory basis, involving increased cellular reactive oxygen species (ROS) accumulation oxidative damage lipids, nucleic acids proteins. The therapeutic benefits curcumin these appear multifactorial via regulation transcription factors, cytokines enzymes associated with (Nuclear factor kappa beta) NFκB activity. This review describes historical use medicine, chemistry, stability biological activities, anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory further discusses pharmacology provides new perspectives on potential limitations. Especially, focuses detail effectiveness mechanism actions treating such as brain malignancies.

Language: Английский

---

Oral bioavailability of curcumin: problems and advancements

Journal of drug targeting, Journal Year: 2016, Volume and Issue: 24(8), P. 694 - 702

Published: March 4, 2016

Curcumin is a natural compound of Curcuma longa L. and has shown many pharmacological activities such as anti-inflammatory, anti-oxidant in both preclinical clinical studies. Moreover, curcumin hepatoprotective, neuroprotective protects against myocardial infarction. Particularly, also demonstrated favorite anticancer efficacy. But limiting factors its extremely low oral bioavailability hampers application therapeutic agent. Therefore, technologies have been developed applied to overcome this limitation. This review described the main physicochemical properties summarized recent studies design development delivery systems for enhance solubility bioavailability, including liposomes, nanoparticles polymeric micelles, phospholipid complexes, microemulsions.

Language: Английский

---

Curcumin and Health

Molecules, Journal Year: 2016, Volume and Issue: 21(3), P. 264 - 264

Published: Feb. 25, 2016

Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides brief review about origin, bioavailability and new research on curcumin synthetized derivatives. It examines beneficial effects health, delving into aspects cancer, effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, neurological, liver respiratory disorders. Thanks all these activities, is positioned an interesting nutraceutical. reason why it has been subjected several modifications in its structure administration form permitted increase effectiveness different diseases, decreasing mortality morbidity associated pathologies.

Language: Английский

---