Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 13022 - 13036

Published: Aug. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Language: Английский

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Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 146, P. 119 - 130

Published: April 25, 2022

Language: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Bioactive Materials, Journal Year: 2021, Volume and Issue: 15, P. 203 - 213

Published: Dec. 20, 2021

Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated performance are urgently desired. Herein, we reported composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, photothermal functions for accelerating healing. gel was composed polyacrylamide (PAM), polydopamine (PDA), magnesium (Mg2+) prepared via two-step procedure: an alkali-induced dopamine pre-polymerization followed radical polymerization adhesiveness Mg2+-synergized activity, inducing survival rate 5.29% S. aureus 7.06% E. coli after near infrared light irradiation. further demonstrated efficient bacteria inhibition, enhanced collagen deposition in full-thickness skin defect rat model. Together, presents dressing adhesion, healing, functions.

Language: Английский

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Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 287, P. 119336 - 119336

Published: March 11, 2022

Language: Английский

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Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 1 - 17

Published: Jan. 19, 2022

Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment wounds. Tissue necrosis aggravates formation irregular All above factors hinder healing chronic To solve these issues, a glucose MMP-9 dual-response temperature-sensitive shape self-adaptive hydrogel (CBP/GMs@Cel&INS) was designed constructed with polyvinyl alcohol (PVA) chitosan grafted phenylboric acid (CS-BA) by encapsulating insulin (INS) gelatin microspheres containing celecoxib (GMs@Cel). Temperature-sensitive CBP/GMs@Cel&INS provides new way to balance fluid-like mobility (self-adapt deep quickly, approximately 37 °C) solid-like elasticity (protect against external forces, 25 hydrogels, while simultaneously releasing on-demand in high-level MMP-9. Moreover, exhibits remodeling self-healing properties, enhanced adhesion strength (39.65 ± 6.58 kPa), down-regulates MMP-9, promotes cell proliferation, migration, consumption. In full-thickness skin defect models, significantly alleviates regulates local wounds, effectively through synergistic effect shape-adaptive character dual-responsive system.

Language: Английский

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All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

Chemistry of Materials, Journal Year: 2022, Volume and Issue: 34(6), P. 2655 - 2671

Published: March 10, 2022

The development of multifunctional injectable adhesive hydrogels with self-healing capacity, shape adaptability, on-demand removability, and excellent photothermal antibacterial activity to promote bacteria-infected wound healing is highly recommended in practical applications. In this work, an multiple-dynamic-bond crosslinked hydrogel was formed by a network dynamic borate/didiol interactions, hydrogen bonding, Schiff base bond. introduction Mussel-inspired catechol groups into the could endow tissues properties, adhere well skin under water good adaptability bent twisted states. mechanical properties improved through interactions catechol-modified crosslinking at low cost easy preparation, be removed without second damage wound. Moreover, polydopamine nanoparticles (PDA NPs) were introduced reactions between quinone group on PDA NPs primary amine glycol chitosan (GC), resulting efficient uniformly dispersed hydrogel. And illustrated cytocompatibility hemocompatibility. Finally, they injected fully fill irregular wounds significantly reducing inflammatory response, accelerating collagen deposition, promoting blood vessel reconstruction. Therefore, demonstrated their superiority serving as dressings for treating

Language: Английский

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Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Feb. 12, 2023

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant

Language: Английский

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Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 49 - 70

Published: Feb. 1, 2022

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment motor system injury, digestive disease, oculopathy, bioelectronics. In this review, starting with the classification common hydrogels, pyramid evolution process from structures derived then applications is elaborated, well efficient reverse design considerations hydrogel systems are proposed. Finally, existing problems development prospects these materials discussed. It hoped that perspective review can promote further innovation breakthroughs future.

Language: Английский

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