Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Aug. 22, 2023
The
treatment
of
chronic
and
non-healing
wounds
in
diabetic
patients
remains
a
major
medical
problem.
Recent
reports
have
shown
that
hydrogel
wound
dressings
might
be
an
effective
strategy
for
treating
due
to
their
excellent
hydrophilicity,
good
drug-loading
ability
sustained
drug
release
properties.
As
typical
example,
hyaluronic
acid
dressing
(Healoderm)
has
been
demonstrated
clinical
trials
improve
wound-healing
efficiency
healing
rates
foot
ulcers.
However,
the
degradation
behavior
clinically-used
cannot
adjusted
according
microenvironment.
Due
intricacy
wounds,
antibiotics
other
medications
are
frequently
combined
with
practice,
although
these
easily
hindered
by
hostile
environment.
In
this
case,
scientists
created
responsive-hydrogel
based
on
microenvironment
features
(such
as
high
glucose
low
pH)
or
external
stimuli
light
magnetic
field)
achieve
controllable
release,
gel
degradation,
improvements
order
overcome
issues.
These
anticipated
play
significant
role
therapeutic
dressings.
Here,
we
review
recent
advances
towards
healing,
focus
structure
design,
principle
responsiveness,
degradation.
Last
but
not
least,
advantages
limitations
responsive-hydrogels
applications
will
also
discussed.
We
hope
contribute
furthering
progress
hydrogels
improved
practical
application.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(31)
Published: April 23, 2023
Abstract
Wound
with
drug‐resistant
bacterial
infections
has
become
a
serious
challenge
for
the
healthcare
system,
and
designing
wound
dressing
to
self‐adapt
need
of
different
stage
healing
remains
challenging.
Herein,
self‐adaptive
dressings
multiple
stimuli‐responsiveness
antibacterial
activity
are
developed.
Specifically,
MoS
2
carrying
reactive
oxygen
species
(ROS)
responsive
nitric
oxide
(NO)
release
precursor
L‐arginine
(MSPA)
is
designed
incorporated
into
carboxymethyl
chitosan/
poly(
N‐isopropylacrylamide)
based
cryogels
(CMCS/PNIPAM)
responsiveness
(pH,
near
infrared
(NIR),
temperature)
form
that
adapt
therapeutic
needs
stages
in
infected
healing.
In
response
slightly
acidic
environment
infection,
assist
capture
capacity
through
acid‐triggered
protonation
behavior,
effectively
enhance
photodynamic
efficiency.
Controllable
on‐demand
delivery
ROS,
NO,
remote
management
biofluid
achieved
NIR
light
as
trigger
switch.
The
stimuli‐responsive
nanozyme‐based
efficiently
eliminate
MRSA
biofilm
NO
assisted
photodynamicand
photothermal
therapy
(PDT&PTT).
enzyme‐like
activities
relieved
oxidative
damage.
Notably,
these
reduce
alleviated
stress,
accelerate
collagen
deposition
angiogenesis
wounds,
indicating
provide
new
ideas
treatment.
BMEMat,
Journal Year:
2023,
Volume and Issue:
1(2)
Published: April 15, 2023
Abstract
Due
to
global
aging
problems,
the
rising
number
of
patients
suffering
from
chronic
or
hard‐to‐heal
acute
wounds
imposes
a
significant
burden
on
healthcare
systems.
Wound
healing
is
complicated
and
dynamic
physiological
process
with
distinct
molecular
cellular
levels
at
each
phase.
Despite
numerous
strategies
advanced
wound
dressings
being
developed,
successful
management
through
smart
dressing
materials
that
can
adapt
changing
microenvironments
address
needs
different
stages
remains
big
challenge.
Over
last
decade,
hydrogel‐based
have
emerged
as
one
most
potent
biomaterials
for
treatment
favorable
biological
characteristics
high
potential
active
intervention
during
wound‐curing
process.
In
current
contribution,
we
present
recent
progress
in
hydrogel
regulate
release
therapeutics
response
external
stimuli
(such
light)
well
endogenous
changes
environments
(e.g.,
temperature,
pH,
glucose,
reactive
oxygen
species)
facilitate
healing.
We
also
introduce
cutting‐edge
technologies
intelligent
“sense‐and‐treat”
combination
built‐in
sensors
sensing
molecules
responsive
hydrogels,
which
enable
real‐time
monitoring
conditions
prompt
on‐demand
therapy.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 22015 - 22034
Published: Oct. 20, 2023
Developing
injectable
antiswelling
and
high-strength
bioactive
hydrogels
with
wet
tissue
adhesiveness
a
rapid
gelling
process
to
meet
the
requirements
for
hemostasis,
sutureless
wound
closure,
scar-free
repair
of
infected
skin
wounds
continues
have
ongoing
challenges.
Herein,
injectable,
antibacterial,
antioxidant
hydrogel
adhesives
based
on
poly(citric
acid-co-polyethylene
glycol)-g-dopamine
amino-terminated
Pluronic
F127
(APF)
micelles
loaded
astragaloside
IV
(AS)
are
prepared.
The
H2O2/horseradish
peroxidase
(HRP)
system
is
used
cause
cross-linking
network
through
oxidative
coupling
between
catechol
groups
chemical
group
amino
group.
exhibit
process,
high
mechanical
strength,
an
effect,
good
property,
H2O2
release
behavior,
degradability.
In
addition,
present
adhesiveness,
bursting
pressure,
excellent
antibacterial
activity,
long-term
sustained
AS,
biocompatibility.
perform
hemostasis
mouse
liver,
rat
rabbit
femoral
vein
bleeding
models
achieve
much
better
closure
healing
incisions
than
biomedical
glue
surgical
sutures.
Furthermore,
dressing
significantly
improved
MRSA-infected
full
thickness
defect
by
modulating
inflammation,
regulating
ratio
collagen
I/III,
improving
vascularization
granulation
formation.
Thus,
AS-loaded
show
huge
potential
as
multifunctional
dressings
in
vivo
wounds.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
17, P. 100499 - 100499
Published: Nov. 19, 2022
Millions
of
people
die
annually
due
to
uncured
wound
infections.
Healthcare
systems
incur
high
costs
treat
Tt
is
predicted
become
more
challenging
the
rise
multidrug-resistant
conditions.
During
last
decades,
smart
antibacterial
hydrogels
could
attract
attention
as
a
promising
solution,
especially
for
skin
These
are
termed
'smart'
their
response
specific
physical
and
chemical
environmental
stimuli.
To
deliver
different
drugs
particular
sites
in
controlled
manner,
various
types
crosslinking
strategies
used
manufacturing
process.
Smart
designed
provide
antimicrobial
agents
infected
or
built
from
polymers
with
inherent
disinfectant
properties.
This
paper
aims
critically
review
recent
pre-clinical
clinical
advances
using
against
infections
propose
next
best
thing
future
trends.
For
this
purpose,
an
introduction
healing
disease
presented
intelligent
responding
stimuli
introduced.
Finally,
most
investigations
discussed
related
sections.
studies
can
pave
way
producing
new
biomaterials
applications.
