The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 28, 2023

Abstract Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant using chimeric antigen receptor T cells. The CAR with its FDA-approved drugs, could treat several types of hematological malignancies thus be very attractive for treating solid cancer. Unfortunately, the cannot functional cancers due to unique features. This treatment method harmful adverse effects that limit their applications, so novel treatments must use new cells like NK cells, NKT macrophage Among these innate features, are more tumor seem a better candidate prior methods. have vital roles microenvironment and, direct effect, can eliminate efficiently. In addition, being part immune system, attended sites. With high infiltration, modulations effective. review investigates last achievements CAR-macrophage future immunotherapy method.

Language: Английский

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Therapeutic m⁶A Eraser ALKBH5 mRNA-Loaded Exosome–Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11838 - 11854

Published: June 13, 2023

Although therapeutic targets have been developed for colorectal cancer (CRC) therapy, the effects are not ideal and survival rate CRC patients remains poor. Therefore, it is crucial to recognize a specific target develop an efficacious delivery system therapy. Herein, we demonstrate that reduced ALKBH5 mediates aberrant m6A modification tumor progression in CRC. Mechanically, histone deacetylase 2-mediated H3K27 deacetylation inhibits transcription CRC, whereas ectopic expression decreases tumorigenesis of cells protects mice from colitis-associated development. Further, METTL14/ALKBH5/IGF2BPs combine modulate JMJD8 stability m6A-dependent manner, which increases glycolysis accelerates development by enhancing enzymatic activity PKM2. Moreover, mRNA-loaded folic acid-modified exosome–liposome hybrid nanoparticles were synthesized significantly inhibit preclinical models modulating ALKBH5/JMJD8/PKM2 axis inhibiting glycolysis. Overall, our research confirms function regulating status provides direct approach using mRNA nanotherapeutics

Language: Английский

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Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4751 - 4778

Published: Aug. 1, 2023

Abstract: Exosomes, as natural nanocarriers, characterized with low immunogenicity, non-cytotoxicity and targeted delivery capability, which have advantages over synthetic nanocarriers. Recently, exosomes shown great potential diagnostic markers for diseases are also considered a promising cell-free therapy. Engineered significantly enhanced the efficacy precision of delivering therapeutic agents, currently being extensively employed in investigations various ailments, including oncology, inflammatory disorders, degenerative conditions. Particularly, engineered enable agent loading, modification, evasion MPS phagocytosis, intelligent control, bioimaging, been developed multifunctional nano-delivery platforms recent years. The utilization bioactive scaffolds that loaded exosome has to substantially augment retention, extend release, enhance efficacy. This approach advanced from conventional hydrogels nanocomposite hydrogels, nanofiber 3D printing, resulting superior physical biological properties effectively address limitations scaffolds. Additionally, plant-derived exosomes, can participate gut flora remodeling via oral administration, an ideal platform treatment intestinal diseases. Consequently, there is interest nanocarriers applications. comprehensive review provides overview biogenesis, composition, isolation methods exosomes. it examines pathological mechanisms diseases, tumors, Furthermore, this highlights significance microbial-derived Strategies specific applications scaffold-loaded further summarized, especially some new techniques such large-scale loading technique, macromolecular development nano-scaffold-loaded delivery. benefits using gut-related discussed. challenges, opportunities, prospects exosome-based disease diagnosis summarized both preclinical clinical viewpoints. Keywords: diagnosis,

Language: Английский

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Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 124 - 146

Published: Oct. 4, 2023

Due to its multiple features, including the ability orchestrate remote communication between different tissues, exosomes are extracellular vesicles arousing highest interest in scientific community. Their size, established as an average of 30-150 nm, allows them be easily uptaken by most cells. According type cells-derived exosomes, they may carry specific biomolecular cargoes used reprogram cells interacting with. In certain circumstances, stimulate immune response facilitating or amplifying release foreign antigens-killing cells, inflammatory factors, antibodies (immune activation). Meanwhile, other cases, efficiently malignant elements such cancer mislead recognition mechanism, carrying and transferring their cancerous distant healthy thus contributing antigenic invasion suppression). Exosome dichotomic patterns upon system regulation present broad advantages immunotherapy. Its perfect comprehension, from early biogenesis interaction with recipient will promote a significant enhancement immunotherapy employing molecular biology, nanomedicine, nanotechnology.

Language: Английский

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Research progress of organic photothermal agents delivery and synergistic therapy systems

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113743 - 113743

Published: Jan. 5, 2024

Language: Английский

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