An Anticoagulant Coating Based on a Block Phosphocholine Copolymer for Potential Applications in Blood Contact Devices DOI Creative Commons
Xinli Lu,

Yahong Kang,

Xuebin Wang

et al.

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract As the core component of ventricular assist devices, blood pumps have been widely used in clinical treatment. However, thrombus caused by contact inner surface with still remain a serious risk. The zwitterionic coating has ability to form hydration layer inhibit protein and cell adhesion, which makes it potential strategy solve coagulation on device. Herein, phosphocholine is presented formed block copolymer poly(2‐methylacryloxyethyl phosphatecholine‐ b ‐glycidyl methacrylate (PMPC‐ ‐GMA). Poly(MPC) poly(GMA) are intended provide, respectively, resistance formation adhesion material surface. copolymers synthesized through reversible addition‐fragmentation chain transfer polymerization achieve an accurate molecular design. After dip‐coated materials, exhibits platelet ability, anticoagulant vitro biocompatibility. Furthermore, vivo biocompatibility confirmed implantation coated polycarbonate substrate rats. This study provides promising pathway for regulating interaction between biomaterials proteins, platelets, bioactive molecules, expected guide further development coatings ensure safety devices

Language: Английский

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases DOI
Yunbing Wang, Gaocan Li, Li Yang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(46)

Published: June 2, 2022

Abstract Cardiovascular diseases have become the leading cause of death worldwide. The increasing burden cardiovascular has a major public health problem and how to carry out efficient reliable treatment an urgent global be solved. Recently, implantable biomaterials devices, especially minimally invasive interventional ones, such as vascular stents, artificial heart valves, bioprosthetic cardiac occluders, graft patches, atrial shunts, injectable hydrogels against failure, most effective means in diseases. Herein, overview challenges research frontier innovative devices for is provided, their future development directions are discussed.

Language: Английский

Citations

107
Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis DOI Creative Commons

Deqiang Yuan,

Jiapeng Chu, Hao Lin

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 16, 2023

Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from methionine to cysteine. When fasting plasma Hcy level higher than 15 μmol/L, it considered as hyperhomocysteinemia (HHcy). The vascular endothelium important barrier homeostasis, and its impairment initiation of atherosclerosis (AS). HHcy risk factor for AS, which can promote development AS occurrence cardiovascular events, damage play a very role. However, mechanism by damages still not fully understood. This review summarizes Hcy-induced endothelial injury treatment methods alleviate induced dysfunction, in order provide new thoughts diagnosis subsequent AS-related diseases.

Language: Английский

Citations

68
A glucose-responsive nitric oxide release hydrogel for infected diabetic wounds treatment DOI
Xiang Zhou, Bing Zhao, Lanlan Wang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 359, P. 147 - 160

Published: June 8, 2023

Language: Английский

Citations

45
Nanomedicine for Diagnosis and Treatment of Atherosclerosis DOI Creative Commons
Jingyun Cheng, Hui Huang, Yu Chen

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)

Published: Oct. 28, 2023

Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.

Language: Английский

Citations

40
Surface Engineering of Central Venous Catheters via Combination of Antibacterial Endothelium‐Mimicking Function and Fibrinolytic Activity for Combating Blood Stream Infection and Thrombosis DOI
Kaijun Li, Jinyu Peng, Yuqi Liu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 11, 2023

Abstract Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration endothelium‐mimicking fibrinolytic functions. In proposal, lysine (Lys)/Cu 2+ ‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed robustly fabricated onto commercial using facile two‐step process. Initially, adhesive ene ‐functionalized dopamine covalently reacted with Lys simultaneously coordinated bactericidal Cu ions, leading to deposition PDA/Lys/Cu on through mussel foot protein inspired chemistry. Next, poly(sulfobetaine methacrylate) (pSB) brushes are grafted endow lubricant antifouling properties. final PDA/Lys/Cu‐SB coating, function achieved combining catalytic generation nitric oxide from chelated pSB brushes, which led significant prevention thrombosis, bacterial vivo. Furthermore, immobilized activity show remarkably enhanced long‐term anti‐thrombogenic properties evidenced vivo demonstrating capability lyse nascent clots. Therefore, developed provides promising solution combat infection.

Language: Английский

Citations

29
Polyphenol-Reinforced Glycocalyx-Like Hydrogel Coating Induced Myocardial Regeneration and Immunomodulation DOI
Huining Wan,

Xiaohui Yang,

Yutong Zhang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(32), P. 21512 - 21522

Published: Aug. 3, 2024

Although minimally invasive interventional occluders can effectively seal heart defect tissue, they still have some limitations, including poor endothelial healing, intense inflammatory response, and thrombosis formation. Herein, a polyphenol-reinforced medicine/peptide glycocalyx-like coating was prepared on cardiac occluders. A consisting of carboxylated chitosan, epigallocatechin-3-gallate (EGCG), tanshinone IIA sulfonic sodium (TSS), hyaluronic acid grafted with 3-aminophenylboronic prepared. Subsequently, the mercaptopropionic acid-GGGGG-Arg-Glu-Asp-Val peptide by thiol-ene "click" reaction. The showed good hydrophilicity free radical-scavenging ability could release EGCG-TSS. results biological experiments suggested that reduce promoting endothelialization, promote myocardial repair regulating response. functions cardiomyocyte apoptosis metabolism were confirmed, regulatory mainly dependent

Language: Английский

Citations

10
Biophysiochemically favorable, antithrombotic and pro-endothelial coordination compound nanocoating of copper (II) with protocatechuic acid & nattokinase on flow-diverting stents DOI

Zhaozhao Zhang,

Fei Gao,

Jinlong Mao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114509 - 114509

Published: Jan. 14, 2025

Language: Английский

Citations

1
Construction of small-diameter vascular grafts by electrospun zwitterionic diselenide-containing poly(ester urethane)urea with enhanced endothelialization DOI
Liang Yuan, Yong Gao, Qing Wang

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Wireless Thermoelectric Hydrogel Recreates Biomimetic Electric Field and Angiogenic Signal Accelerating Diabetic Ulcer Repair DOI

Minhong Tan,

Yuda Liu, Yiyi Wang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Endogenous electric field (EF)‐actuated reepithelization, dermal formation, and growth factors‐induced angiogenesis are crucial for wound healing. It is however, challenging to initiate both endogenous EF factors in diabetic ulcer due severe electrolyte loss hyperglycemia‐resulted endothelial dysfunction. Current therapeutic systems supply electrostimulation by integrating self‐powered conductive materials continue encounter obstacles nondegradability‐induced low biocompatibility anisotropic EF‐resulted limited regeneration. Recombinant also high cost, stability, potential bio‐risk. Herein, a wireless biocompatible thermoelectric hydrogel (HFN) co‐crosslinked biodegradable hyaluronic acid polyether F127 developed achieve effective directional‐EF stimulation. Target‐modified ginseng‐derived exosomes (RGE) further embedded the design of HFN‐RGE enhanced Specifically, recreates biomimetic through “cationic trap” effect trigger robust epithelial fibroblast electrotaxis, meanwhile controlling release precise pro‐angiogenic with unique ability reverse In vivo, demonstrated stimulate reepithelialization, regeneration, nascent vessel network reconstruction. Single‐cell RNA‐seq revealed that activates PPAR signaling‐meditated tissue As such this work provides promising electrical‐biological hybrid system biosafety therapy.

Language: Английский

Citations

1
Lipophilic NO‐Driven Nanomotors as Drug Balloon Coating for the Treatment of Atherosclerosis DOI
Xueting Tang, Lin Chen, Ziyu Wu

et al.

Small, Journal Year: 2022, Volume and Issue: 19(13)

Published: Aug. 12, 2022

Abstract Drug‐coated balloons (DCB) intervention is an important approach for the treatment of atherosclerosis (AS). However, this therapeutic has drawbacks poor drug retention and penetration at lesion site. Here, a lipophilic drug‐loaded nanomotor as modified balloon coating AS reported. First, PMA‐TPP/PTX loaded with PTX triphenylphosphine (TPP) compounds synthesized. The nanomotors use nitric oxide (NO) driving force, which produced from reaction between arginine on motor substrate excess reactive oxygen species (ROS) inducible synthase (iNOS) in microenvironment. final vitro vivo experimental results confirm that introduction technology can greatly enhance permeability atherosclerotic lesions. In particular, NO also play anti‐AS role improving endothelial cell function reducing oxidative stress. chemotherapeutic onto inhibit division proliferation, thereby exerting effect inhibiting vascular intimal hyperplasia, helpful multiple therapies AS. Using to solve cardiovascular diseases may be promising research direction.

Language: Английский

Citations

31