A Review of Recent Progress on Collagen‐Based Biomaterials

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(16)

Published: Nov. 15, 2022

Abstract Since the 2010s, demand for healthcare models has exceeded prevailing resources available due to rapid increase in aging population China. However, a significant gap development of biomedical materials remains, especially between China and western developed countries. Collagen is major protein extracellular matrix (ECM) been extensively applied medical fields. Collagen‐based biomaterials (CBBs) are used prepare dressings dermal substitutes, surgical sutures, plasma tissue‐engineered scaffolds, drug delivery systems; this attributed their exceptional biocompatibility, biodegradability, hypoimmunogenicity, coordination collagen hosts tissues. This review provides thorough strides CBB structures, crosslinking forming technologies, real‐world applications. First, natural origin specific structures animal‐derived non‐animal‐derived introduced compared. Second, methods technologies CBBs across board discussed. Third, several examples considered demonstrate practical use highlight cautionary notes. Finally, underlying directions from an interdisciplinary perspective outlined. aims provide comprehensive mechanisms by which can be uniquely practically as advanced biomaterial, hence providing options augmenting its

Language: Английский

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Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(32), P. 17881 - 17891

Published: Aug. 2, 2023

Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition fiber caps induced cysteine cathepsin. However, accurate measurement cathepsin B (CTB) activity in plaques challenging due to low specificity insufficient penetration depth available atherosclerosis-associated fluorescent probes, hampering reliable assessment vulnerability. To address these limitations, we added both lipophilic alkyl chain hydrophilic CTB substrate hemicyanine scaffold develop lipid-unlocked responsive probe (L-CRP) that uses lipids two keys unlock photoacoustic (PA) signals for measuring environments. Such properties allow L-CRP imaging specific activities foam cells atherosclerotic while keeping silence toward lipid-deficient environments, M1-type macrophages LPS-induced inflammatory lesions. Moreover, activatable PA exhibit deeper tissue ability (>1.0 cm) than current probes based on near-infrared (∼0.3 cm), suitable atherosclerosis living mice. In mice, dynamically reports intraplaque levels, which well-correlated with vulnerability characteristics cap thickness, macrophage recruitment, necrotic core size, thus enabling risk stratification mice complicated pneumonia. successfully identifies excised human artery tissues, promising auxiliary diagnosis clinical application.

Language: Английский

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Advances in Injectable Hydrogel Strategies for Heart Failure Treatment

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 13, 2023

Heart failure (HF) affects 60 million people worldwide and has developed into a global public health problem surpassing cancer urgently needs to be solved. According the etiological spectrum, HF due myocardial infarction (MI) become dominant cause of morbidity mortality. Possible treatments include pharmacology, medical device implantation, cardiac transplantation, which are limited in their ability promote long-term functional stabilization heart. Injectable hydrogel therapy emerged as minimally invasive tissue engineering treatment approach. Hydrogels can provide necessary mechanical support for infarcted myocardium serve carriers various drugs, bioactive factors, cells improve cellular microenvironment region induce regeneration. Herein, pathophysiological mechanism is explored injectable hydrogels potential solution current clinical trials applications summarized. Specifically, hydrogels, decellularized ECM variety biotherapeutic agent-loaded conductive repair were discussed, action these hydrogel-based therapies was emphasized. Finally, limitations future prospects post MI proposed inspire novel therapeutic strategies.

Language: Английский

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A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 25, 2024

Abstract Drug-eluting stent implantation suppresses the excessive proliferation of smooth muscle cells to reduce in-stent restenosis. However, efficacy drug-eluting stents remains limited due delayed reendothelialization, impaired intimal remodeling, and potentially increased late Here, we show that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response injured tissue following implantation. We demonstrate possesses anticoagulation, anti-inflammatory, hyperplasia suppression properties. perform transcriptome analysis indicate favors endothelialization process induces conversion contractile phenotype. find compared stents, our reduces restenosis rabbit porcine models improves vascular neointimal healing model. Collectively, system represents promising strategy for next-generation stents.

Language: Английский

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A Versatile Passivated Protein‐Adsorption Platform for Rapid Healing of Vascular Stents by Modulating the Microenvironment

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract Biodegradable stents have paved the way to treat coronary artery disease. However, rapid reendothelialization is required solve problems of mismatched degradation rates, localized inflammation, and insufficient biocompatibility. Herein, a novel passivated protein‐adsorption coating synthesized by coordination chelation, oxidation, cross‐linking, polymerization, deposition dopamine, (‐)‐epigallocatechin gallate (EGCG), copper ions (Cu 2+ ) using two‐electron oxidation. This exhibits hierarchical functionality, that is, at macroscale, its superhydrophilicity conveys antifouling ability; whereas microscale, active groups (quinone‐, amino‐, hydroxyphenyl aromatic ring) facilitate protein adsorption. Antifouling ability prevents acute thrombosis inflammation maintains initial microenvironment stability post‐implantation. The gradual endothelial cells (ECs) adhesion. Meanwhile, decomposition nitric oxide (NO) donors release NO catalyzed Cu , EGCG alleviates or oxidative stress damage, inflammatory responses, formation, excessive smooth muscle proliferation in stent microenvironment. provides favorable conditions for healthy growth ECs. study proposes strategy neointima formation comprising ECs on surfaces biodegradable depositing (polydopamine/EGCG/Cu), opening new possibilities efficient treatment

Language: Английский

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A polyphenol-derived redox-active and conductive nanoparticle-reinforced hydrogel with wet adhesiveness for myocardial infarction repair by simultaneously stimulating anti-inflammation and calcium homeostasis pathways

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102157 - 102157

Published: Jan. 12, 2024

Language: Английский

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Evolution of biomimetic ECM scaffolds from decellularized tissue matrix for tissue engineering: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 246, P. 125672 - 125672

Published: July 3, 2023

Language: Английский

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Precise Regulation of Inflammation and Oxidative Stress by ROS‐Responsive Prodrug Coated Balloon for Preventing Vascular Restenosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(30)

Published: April 26, 2023

Abstract Vascular restenosis after balloon dilation is largely caused by the over‐proliferation of smooth muscle cells, which triggered and exacerbated local excessive inflammation oxidative stress. The inflammatory stress cause tissue/cell damage, hamper endothelial functions, worsen intimal hyperplasia restenosis. A high level reactive oxygen species (ROS) overproduction regarded as main culprit. Therefore, efficiently inhibiting ROS over‐production or weightily depleting them great significance. Herein, a “ROS‐responsive/scavenging prodrug” introduced into coating for treatment vascular reversible phenylboronic ester‐bearing caffeic acid (CA) macromolecular prodrug (PBC) designed controlled on‐demand dual‐drug release level; released CA 4‐hydroxybenzyl alcohol exhibit efficient antioxidant anti‐inflammatory effects scavenging ROS, thereby regulating microenvironment protecting endothelium functions. To accelerate regeneration, pro‐endothelial microRNA‐126 further introduced. ROS‐responsive/scavenging prodrug/miRNA prevents hyperplasia, alleviates inflammation, improves healing in rat abdominal aorta model, may provide applicative perspectives next‐generation drug‐coated balloons other cardiovascular diseases treatment.

Language: Английский

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Application of biomedical materials in the diagnosis and treatment of myocardial infarction

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 26, 2023

Myocardial infarction (MI) is a cardiovascular emergency and the leading cause of death worldwide. Inflammatory immune responses are initiated immediately after MI, to myocardial death, scarring, ventricular remodeling. Current therapeutic approaches emphasize early restoration ischemic reperfusion, but there no effective treatment for pathological changes infarction. Biomedical materials development has brought new hope MI diagnosis treatment. materials, such as cardiac patches, hydrogels, nano biomaterials, artificial blood vessels, have played an irreplaceable role in They improve accuracy efficacy offer further possibilities reducing inflammation, immunomodulation, inhibiting fibrosis, regeneration. This review focuses on advances biomedical applications The current studies outlined terms mechanisms action effects. It addressed how application can lessen damage, encourage angiogenesis, enhance heart function. Their clinical transformation value prospect discussed.

Language: Английский

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Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(8)

Published: Dec. 20, 2023

Surfaces with biological functionalities are of great interest for biomaterials, tissue engineering, biophysics, and controlling processes. The layer-by-layer (LbL) assembly is a highly versatile methodology introduced 30 years ago, which consists assembling complementary polyelectrolytes or biomolecules in stepwise manner to form thin self-assembled films. In view its simplicity, compatibility molecules, adaptability any kind supporting material carrier, this technology has undergone major developments over the past decades. Specific applications have emerged different biomedical fields owing possibility load immobilize preserved bioactivity, use an extremely broad range carriers, modify film's mechanical properties via crosslinking. review, focus on recent regarding LbL films formed as 2D 3D objects drug delivery engineering. Possible vaccinology, biomimetic models, well bone cardiovascular engineering highlighted. addition, most technological field film construction, such high-content liquid handling machine learning, expected open new perspectives future LbL, presented.

Language: Английский

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