Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(2)

Published: Nov. 7, 2023

Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack spatiotemporal management immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as smart‐responsive therapeutic system (GA/BPPD) for accelerated regeneration. BPPD nanocomposites served bioactive components near‐infrared (NIR) photothermal agents, which conferred with excellent NIR/pH dual‐responsive properties, realizing stimuli‐responsive release DFO PO 4 3 − during Under action NIR‐triggered mild therapy, GA/BPPD exhibited positive effect on promoting osteogenesis angiogenesis, eliminating excessive reactive oxygen species, inducing macrophage polarization M2 phenotype. More significantly, through polarization‐induced osteoimmune this platform could also drive functional cytokine secretion enhanced angiogenesis osteogenesis. In vivo experiments further demonstrated that facilitate healing attenuating local inflammatory response, increasing pro‐healing factors, stimulating endogenous cell recruitment, accelerating revascularization. Collectively, proposed intelligent provides promising strategy reshape damaged tissue microenvironment augmented

Language: Английский

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The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: July 31, 2023

Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures reduce all kinds of trauma and improve the combat effectiveness troops, it is imperative develop new strategies scaffolds promote bone regeneration.

Language: Английский

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Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

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Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4014 - 4057

Published: Jan. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Language: Английский

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Jan. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Language: Английский

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The potential of organic piezoelectric materials for next-generation implantable biomedical devices

Nano Trends, Journal Year: 2024, Volume and Issue: 6, P. 100032 - 100032

Published: March 21, 2024

Piezoelectricity or piezoelectric effect is a phenomenon by which mechanical energy converted into electrical and vice versa. Piezoelectric has been observed in several organic materials. Therefore, past few years materials have received significant research interests biomedical applications specifically for fabrication of implantable devices because their high performance, excellent biocompatibility biodegradability, superior properties, cheap process. This article provides comprehensive review the recent progress on It extensively covers properties preparation methods different including amino acids, peptides, proteins, polysaccharides, polymers (such as PVDF, PLLA, PHB), well representative device namely biosensing, tissue regeneration, drug delivery. Finally, discusses challenges future directions this field.

Language: Английский

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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 94 - 107

Published: Feb. 4, 2025

Language: Английский

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Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.

Language: Английский

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Piezoelectrical Hydrogel Containing Cationic Vacancies Bismuth Sulfide with Enhanced Sonodynamic/Nanozyme Activity for Synergistic Killing Bacteria and Boosting Osteoblast Differentiation

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3420 - 3436

Published: Jan. 1, 2025

A piezoelectric nanozyme is a novel biomaterial with the integration of piezoelectricity and activity that has capability killing bacteria promoting cell responses under mechanical stimulus exhibits great prospects in tissue regeneration. Herein, bismuth sulfide (BS) cationic vacancies (VBS) was synthesized, which enhanced activities compared BS. Moreover, hydrogel VBS phenylboronic acid grafted sodium alginate-arginine (VBS-PSA) prepared. Triggered by ultrasound (US) high power (>0.5 W cm-2), VBS-PSA produces large amount reactive oxygen species (ROS) through both piezoelectricity-enhanced sonodynamic efficiency peroxidase-like (POD-like) activity, thereby displaying powerful antibacterial capability. However, low-power US (≤0.5 effect generates electrical signals significantly stimulate osteoblast (proliferation differentiation) enhance catalase-like (CAT-like) for scavengers ROS generation oxygen, creating favorable microenvironment growth. Our study presents strategy to apply hydrogels enhancing synergistically kill responses. The would have potential repair infected bone defects.

Language: Английский

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Microenvironment-targeted strategy steers advanced bone regeneration

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100741 - 100741

Published: July 20, 2023

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) terms structure composition. However, synergistic effects other cues from microenvironment during regeneration are often neglected. The is sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical oxygen, pH), physical factors mechanics, acoustics) dynamically interact with each other. Microenvironment-targeted increasingly recognized crucial for successful offer promising solutions advancing engineering. This review provides comprehensive overview current microenvironment-targeted challenges further outlines prospective directions approaches construction organoids.

Language: Английский

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