MedComm – Biomaterials and Applications,
Journal Year:
2023,
Volume and Issue:
2(2)
Published: April 14, 2023
Abstract
Copper
(Cu)
is
an
essential
trace
element
in
the
human
body
that
involved
formation
of
several
natural
enzymes,
such
as
superoxide
dismutase
and
cyclooxygenase.
Due
to
high
density
outer
electron
cloud
Cu,
which
allows
transfer
multiple
electrons,
Cu
often
used
catalytic
center
various
metabolic
enzymes.
However,
both
deficiency
excessive
accumulation
can
result
irreversible
damage
cells.
Therefore,
strategies
regulate
metabolism,
exhaustion
supplementation,
have
emerged
attractive
approaches
anticancer
therapy,
due
potential
damages
caused
by
metabolism
disorders.
Notably,
recent
advancements
nanotechnology
enabled
development
nanomaterials
making
this
therapy
applicable
vivo.
In
review,
we
provide
a
systematic
discussion
physical
chemical
properties
summarize
applications
metabolism‐based
antitumor
therapy.
Finally,
outline
future
directions
challenges
nano‐Cu
emphasizing
scientific
problems
technical
bottlenecks
need
be
addressed
for
successful
clinical
translation.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2447 - 2474
Published: March 18, 2024
The
clinical
efficacy
of
current
cancer
therapies
falls
short,
and
there
is
a
pressing
demand
to
integrate
new
targets
with
conventional
therapies.
Autophagy,
highly
conserved
self-degradation
process,
has
received
considerable
attention
as
an
emerging
therapeutic
target
for
cancer.
With
the
rapid
development
nanomedicine,
nanomaterials
have
been
widely
utilized
in
therapy
due
their
unrivaled
delivery
performance.
Hence,
considering
potential
benefits
integrating
autophagy
nanotechnology
therapy,
we
outline
latest
advances
autophagy-based
nanotherapeutics.
Based
on
brief
background
related
nanotherapeutics
impact
tumor
progression,
feasibility
treatment
demonstrated.
Further,
developed
modulate
are
reviewed
from
perspective
cell
signaling
pathways,
including
modulation
mammalian
rapamycin
(mTOR)
pathway,
autophagy-related
(ATG)
its
complex
expression,
reactive
oxygen
species
(ROS)
mitophagy,
interference
autophagosome-lysosome
fusion,
inhibition
hypoxia-mediated
autophagy.
In
addition,
combination
which
nano-autophagy
combined
chemotherapy,
phototherapy,
immunotherapy
also
described.
Finally,
prospects
challenges
efficient
envisioned.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(16), P. 8306 - 8378
Published: Jan. 1, 2024
As
natural
living
substances,
microorganisms
have
emerged
as
useful
resources
in
medicine
for
creating
microbe-material
hybrids
ranging
from
nano
to
macro
dimensions.
The
engineering
of
microbe-involved
nanomedicine
capitalizes
on
the
distinctive
physiological
attributes
microbes,
particularly
their
intrinsic
"living"
properties
such
hypoxia
tendency
and
oxygen
production
capabilities.
Exploiting
these
remarkable
characteristics
combination
with
other
functional
materials
or
molecules
enables
synergistic
enhancements
that
hold
tremendous
promise
improved
drug
delivery,
site-specific
therapy,
enhanced
monitoring
treatment
outcomes,
presenting
substantial
opportunities
amplifying
efficacy
disease
treatments.
This
comprehensive
review
outlines
microbial
derivatives
used
biomedicine
specific
advantages
therapeutic
application.
In
addition,
we
delineate
fundamental
strategies
mechanisms
employed
constructing
hybrids.
diverse
biomedical
applications
constructed
hybrids,
encompassing
bioimaging,
anti-tumor,
anti-bacteria,
anti-inflammation
diseases
therapy
are
exhaustively
illustrated.
We
also
discuss
current
challenges
prospects
associated
clinical
translation
hybrid
platforms.
Therefore,
unique
versatility
potential
exhibited
by
position
them
promising
candidates
development
next-generation
biomaterials
theranostic
functionalities.
MedComm – Biomaterials and Applications,
Journal Year:
2023,
Volume and Issue:
2(2)
Published: April 14, 2023
Abstract
Copper
(Cu)
is
an
essential
trace
element
in
the
human
body
that
involved
formation
of
several
natural
enzymes,
such
as
superoxide
dismutase
and
cyclooxygenase.
Due
to
high
density
outer
electron
cloud
Cu,
which
allows
transfer
multiple
electrons,
Cu
often
used
catalytic
center
various
metabolic
enzymes.
However,
both
deficiency
excessive
accumulation
can
result
irreversible
damage
cells.
Therefore,
strategies
regulate
metabolism,
exhaustion
supplementation,
have
emerged
attractive
approaches
anticancer
therapy,
due
potential
damages
caused
by
metabolism
disorders.
Notably,
recent
advancements
nanotechnology
enabled
development
nanomaterials
making
this
therapy
applicable
vivo.
In
review,
we
provide
a
systematic
discussion
physical
chemical
properties
summarize
applications
metabolism‐based
antitumor
therapy.
Finally,
outline
future
directions
challenges
nano‐Cu
emphasizing
scientific
problems
technical
bottlenecks
need
be
addressed
for
successful
clinical
translation.
